Inflammatory Bowel Disease

Learn more about inflammatory bowel disease

Inflammatory Bowel Disease: An Overview

More than one in 200 Americans live with inflammatory bowel disease (IBD). Scientists at BRI are studying IBD from a variety of angles to understand what goes wrong in the gut to trigger this disease and develop new ways to treat, stop and even prevent it.

Scientists in BRI’s innovative Gut Immunity Program are working to better understand immune system cells and processes within the gut. They’re using innovative tools like organoids (tiny replicas of the human gut) to accelerate their progress. Translational scientists at BRI are using knowledge of immune response processes to create therapies that target what has gone awry. We also work closely with the Center for Digestive Health at Virginia Mason Franciscan Health on clinical trials that study the effectiveness and safety of new treatments.

What Is Inflammatory Bowel Disease?

Inflammatory bowel disease (IBD) is the umbrella term for autoimmune disorders that cause ongoing (chronic) inflammation, pain and bleeding in the digestive tract (the series of hollow organs connected to one another that span from the mouth to the anus). Crohn’s disease and ulcerative colitis (UC) are the two most common forms of IBD. Both happen when the immune system mistakenly attacks the gut. The main difference between Crohn’s disease and ulcerative colitis is the location of this swelling and irritation (inflammation).

At least 1.6 million Americans live with inflammatory bowel disease, and the incidence is on the rise. IBD is usually diagnosed between ages 15-35 and 55-70. It affects men and women at about the same rate.

What is Crohn's disease?

Crohn’s disease can affect any of the organs along the digestive tract, though it is most common in the lining of the last part of the small intestine (the ileum) and the beginning of the large intestine.

Crohn’s disease typically causes inflammation in some places, but not others. The symptoms of Crohn’s disease usually develop over time, but sometimes they come on suddenly.

What is Ulcerative Colitis?

Ulcerative colitis (UC) causes inflammation and sores (ulcers) in the large intestine (which includes the colon and the rectum). It affects the innermost layer of the large intestine’s lining (the mucosa). Unlike Crohn’s disease, the inflammation in UC is continuous and not patchy. In most people, symptoms of UC develop over time rather than all at once.

What Causes Inflammatory Bowel Disease?

Inflammatory bowel disease (IBD) happens when the immune system mistakenly begins attacking the digestive tract, but scientists still don’t know exactly why it happens or how it starts. BRI scientists are working to pinpoint its causes and are currently investigating the interplay of genetics, environmental triggers, and why the immune system starts attacking healthy tissue.

What Are Risk Factors for Inflammatory Bowel Disease?

  • A close family member like a parent, sibling or child who has inflammatory bowel disease (IBD)
  • Age (usually diagnosed before age 30)
  • Northern European ancestry (though IBD can occur in any race)
  • Environmental factors like living in a northern climate, a developed country or an urban area
  • Imbalance in gut microbiome

What is the Difference Between Inflammatory Bowel Disease and Irritable Bowel Syndrome?

Though inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) have some common symptoms – like abdominal pain, constipation and diarrhea – they are not the same condition and require different treatments.

IBS is a group of symptoms that happen when the bowel isn’t working properly. In IBS, there is no inflammation of the tissue and no sign of tissue abnormality.

IBD is an autoimmune disease that causes inflammation in the digestive tract. IBD damages the tissue and causes tissue abnormalities.

IBS is estimated to affect as many as 15% of the United States’ population, making it much more common than IBD, which affects about 1.3% of people in the U.S. In addition, IBS is more common in women than in men, while IBD affects women and men at about the same rate.

What Is the Latest Research Into Inflammatory Bowel Disease?

For three decades, BRI has been working to understand the cells and processes that cause inflammatory bowel disease (IBD). Our research includes:

  • Identifying which cells and processes cause IBD.
  • Learning why immune cells attack harmless bacteria.
  • Understanding the role gut bacteria play in IBD and the immune system overall.
  • Finding ways to slow down or tire out the cells that cause IBD.
  • Figuring out how to match people to the treatments that will work best for them.

Labs Studying Inflammatory Bowel Disease

Harrison Lab Main

Harrison Lab

The Harrison Lab studies the mechanisms controlling host-microbe interactions at barrier tissues, primarily the skin and the gut with the goal to understand how these immune cells promote barrier tissue integrity and repair, and to understand how this goes awry during disease.
View Lab
Lord Lab Main

Lord Lab

The Lord lab is investigating how loss of “tolerance” happens in IBD, to learn how the immune system normally coexists peacefully in close proximity to gut contents.
View Lab
Ziegler Lab Main

Ziegler Lab

The Ziegler laboratory is investigating the role of the epithelial cytokines TSLP and IL-33 in regulating protective responses at mucosal barrier surfaces such as the respiratory and gastrointestinal tracts.
View Lab

Clinical Research Studies in Digestive Health

We have ongoing clinical research studies in several areas of digestive health. Studies labeled as “Enrolling” are actively recruiting new participants while studies labeled as “Closed to Enrollment” are still active but no longer seeking new participants. 

 

Please email Digestive Health Research or call (206) 341-1021 for more information.

 

 

Crohn's Disease

A Phase 2b Randomized, Double-blind, Active- and Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Induction and Maintenance Combination Therapy with Guselkumab and Golimumab in Participants with Moderately to Severely Active Crohn’s Disease
Principal Investigator: Tim Zisman, MD
Status: Enrolling

 


A Follow-up of a Phase 3 Study to Evaluate the Long-term Safety and Efficacy of Darvadstrocel in the Treatment of Complex Perianal Fistula in Subjects With Crohn's Disease Who Have participated in ADMIRE II Study
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects with Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or are Intolerant to Biologic Therapy
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects with Crohn's Disease who Completed the Studies M14-431 or M14-433
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study to Assess the Efficacy and Safety of Risankizumab in Subjects with Moderately to Severely Active Crohn's Disease Who Failed Prior Biologic Treatment
Status: Closed to Enrollment

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of BMS-986165 in Subjects with Moderate to Severe Crohn's Disease
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

A Phase 2, Multicenter, Open-Label Extension (OLE) Study to Observe the Long-Term Efficacy, Safety, and Tolerability of Repeated Administration of Upadacitinib (ABT-494) in Subjects with Crohn's Disease
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

A Phase 3, Multicenter, Open-Label, Long-Term Extension Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Patients with Crohn's Disease
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Etrolizumab as an Induction and Maintenance Treatment for Patients with Moderately to severely active Crohn's Disease
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

A phase III, randomized, double blind, parallel group, placebo controlled, international, multicentre study to assess efficacy and safety of Cx601, adult allogeneic expanded adipose-derived stem cells (eASC), for the treatment of complex perianal fistula(s) in patients with Crohn's disease over a period of 24 weeks and a follow up period up to 52 weeks. ADMIRE-CD II study
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

Crohn's Disease: Risankizumab versus Ustekinumab for Subjects with Crohn's Disease
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

GA29145-An Open-Label Extension and Safety Monitoring Study of Patients with Moderately to Severly Active Crohn's Disease Previously Enrolled in the Etrolizumab Phase II PRotocol GA29144
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

Phase 3b Open-label Study to Determine the Long-term Safety and Efficacy of Vedolizumab Subcutaneous in Subjects with Ulcerative Colitis and Crohn's Disease
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

Ulcerative Colitis

A Phase 2b Randomized, Double-blind, Active- and Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Induction and Maintenance Combination Therapy with Guselkumab and Golimumab in Participants with Moderately to Severely Active Ulcerative Colitis
Principal Investigator: Tim Zisman, MD
Status: Enrolling

 


A Multicenter, Randomized, Double-Blind, Placebo-Controlled 52-Week Maintenance and an Open-Label Extension Study of the Efficacy and Safety of Risankizumab in Subjects with Ulcerative Colitis Who Responded to Induction Treatment in M16-067 or M16-065
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study to Evaluate the Efficacy and Safety of Risankizumab in Subjects with Moderately to Severely Active Ulcerative Colitis Who Have Failed Prior Biologic Therapy
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

A Phase 3 Multicenter, Open-Label Extension (OLE) Study to Evaluate the Long-Term Safety and Efficacy of ABT-494 in Subjects with Ulcerative Colitis (UC)
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, 52-Week Study to Assess the Efficacy and Safety of Etrasimod in Subjects with Moderately to Severely Active Ulcerative Colitis
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Protocol to Evaluate the Safety and Efficacy of Ustekinumab Induction and Maintenance Therapy in Subjects with Moderate to Severe Ulcerative Colitis
Principal Investigator: James Lord, MD
Status: Closed to Enrollment

A Randomized, Double-Blind, Placebo-Controlled, 52-Week Study to Assess the Efficacy and Safety of Etrasimod in Subjects with Moderately Active Ulcerative Colitis
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

An Open-Label Extension Study of Etrasimod in Subjects with Moderately to Severely Active Ulcerative Colitis
Principal Investigator: Tim Zisman, MD
Status: Closed to Enrollment

Are You Living With Inflammatory Bowel Disease?

Support inflammatory bowel disease research at BRI by participating in our gastrointestinal diseases biorepository.

Blog Stories

Feature - Clinical Research Subject Blue
September 19, 2023

An Insider's Look Into Clinical Trials at BRI

Before medicines become widely available, they have to be rigorously tested — first in the lab, then in people through clinical trials.
Read Article
Dr. Buckner reviewing information
February 4, 2023

BRI's Vision of Immune Health

A message from BRI President Jane Buckner, MD, about BRI's new, broader vision for immune health.
Read Article
Blog Main Image - 2D Abstract Telemedicine Online Healthcare
September 14, 2022

Clues into Crohn's: Exploring Why the Immune System Attacks Beneficial Bacteria

Your gut is home to a huge community of bacteria called the microbiome. Some bacteria are good, some are bad — and some might hold the key to understanding an inflammatory bowel disease (IBD) like Crohn’s disease and ulcerative colitis.

Read Article

Immuno-what? Hear the latest from BRI

Keep up to date on our latest research, new clinical trials and exciting publications.