BRI has recently been awarded a grant to build a Down syndrome (DS) biorepository. Individuals with DS have up to a 100-fold increased risk of developing an autoimmune disease, however, our understanding of why people with DS are so prone to autoimmunity is limited. This research aims to learn why individuals with DS have increased autoimmunity at the cellular mechanism level, which will benefit both people with and without DS living with autoimmune disease. More