Where we begin

Understanding the immune system

Scientists in our Center for Fundamental Immunology conduct research to better understand how the immune system works in health and disease. We use advanced tools, technologies and methods to study the genes, cells and molecules in the immune system, often in partnership with BRI’s Center for Systems Immunology. Our work includes building complex models of autoimmune and inflammatory diseases to study them in precise detail. We also examine samples from people with and without immune system diseases to gain insight into what goes wrong in disease and to identify possible targets for new therapies.

We work closely with BRI’s Centers for Translational Immunology and Interventional Immunology. These groups build on our fundamental insights, seeking out applications for our research in human immunology and patient care. We also collaborate with these centers to analyze clinical trial data to better understand the mechanistic basis for new immune therapies.

Daniel Campbell

Daniel J. Campbell, PhD

Director, Center for Fundamental Immunology; Member; Principal Investigator, Campbell Lab
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Labs in the Center for Fundamental Immunology

Bettelli Lab Main

Bettelli Lab

The main focus of the Bettelli Lab is to identify the cell types of the immune system and mechanisms, which induce and regulate the development of autoimmunity.
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Campbell Lab Main

Campbell Lab

The Campbell laboratory is interested in understanding the basis for T cell activation, function and tolerance.
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Hamerman Lab Main

Hamerman Lab

The lab is interested in understanding how myeloid cells contribute to both productive and pathological immune responses during infection, inflammation, and autoimmune diseases.
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Harrison Lab Main

Harrison Lab

The Harrison Lab studies the mechanisms controlling host-microbe interactions at barrier tissues, primarily the skin and the gut with the goal to understand how these immune cells promote barrier tissue integrity and repair, and to understand how this goes awry during disease.
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Lacy-Hulbert Res Proj Main - Forward Genetics

Lacy-Hulbert Lab

The Lacy-Hulbert lab works to understand how different aspects of the immune system cooperate to identify and combat potentially infectious organisms while preventing immune attack against innocuous microbes or the body’s own self.
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Morawski Lab Main (Action Shot)

Morawski Lab

The Morawski lab studies the adaptive immune response occurring during human inflammatory and autoimmune diseases of the skin and other barrier tissues.
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Ziegler Lab Main

Ziegler Lab

The Ziegler laboratory is investigating the role of the epithelial cytokines TSLP and IL-33 in regulating protective responses at mucosal barrier surfaces such as the respiratory and gastrointestinal tracts.
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Feature - Gut Immunity Group

Gut Immunity Program

The Gut Immunity Program studies how immune responses in the gut go wrong and lead to inflammatory bowel diseases (IBD) such as, celiac disease, Crohn's & colitis and other autoimmune conditions. Researchers use model systems, biorepository samples and clinical studies to understand how immune responses go awry. They also study the gut microbiome and how immune responses in the gut contribute to other autoimmune diseases.
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News Science in Seattle

LITAF Protects Against Pore-Forming Protein–Induced Cell Death by Promoting Membrane Repair: Interview with Drs. Stefani & Lacy-Hulbert

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News American Association of Immunologists AAI

Benaroya Research Institute’s Steven F. Ziegler, PhD, Named 2024 Distinguished Fellow by the American Association of Immunologists

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News American Association of Immunologists AAI

Benaroya Research Institute President Jane Buckner, MD, Receives 2024 American Association of Immunologists’ Steinman Award for Human Immunology Research

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