We use big data to answer big questions

The intersection of biology, immunology and data analysis

Systems immunology is an area of research that uses mathematics and computer analysis to examine cells, molecules and processes in the immune system. BRI’s Center for Systems Immunology uses the latest tools to collect, process and examine data from studies across BRI and around the world. We select and implement new technologies and develop approaches to organize and analyze large data sets. Our goal is to make new insights about the immune system and the diseases that affect it.

Adam Lacy-Hulbert
Associate Member

Adam Lacy-Hulbert, PhD

Director, Center for Systems Immunology; Associate Member; Principal Investigator, Lacy-Hulbert Lab
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Labs in the Center for Systems Immunology

Altman Lab Main

Altman Lab

The Altman lab focuses on use of whole genome transcriptional profiling and multi-omics approaches, and leverages big-data computational biology to understand the molecular mechanisms underpinning severe asthma and other immunologic diseases.
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Bolouri Lab Main

Bolouri Lab

The Bolouri lab is interested in developing and applying computational systems immunology methods to better understand dysregulated immune cell development and differentiation.
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Linsley Lab Main

Linsley Lab

Our goal is to develop and use cutting edge systems biology approaches to elucidate molecular signatures of complex immune diseases, understand the mechanisms of disease, and identify the right therapy for the right patient.
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Ray Lab Main

Ray Lab

The Ray Lab is interested in better understanding how genetic variation tunes our immune system and how this can put individuals at risk for autoimmune diseases.
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Stefani Lab Main

Stefani Lab

The goal of our research is to better understand mechanisms of sensing and repair during diseases like cancer, infections, and neurodegenerative disorders.
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Groups in the Center for Systems Immunology

Research Project Preview Group - Bioinformatics

Bioinformatics Group

The Bioinformatics Group partners with researchers throughout BRI to help make sense of complex multi-dimensional data.  They are an integral part of the Center for Systems Immunology and are a prime example of the institutes many internal resources.

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Research Project Preview - Gut Immunity Group

Gut Immunity Program

The Gut Immunity Program studies how immune responses in the gut go wrong and lead to inflammatory bowel diseases (IBD) such as, celiac disease, Crohn's & colitis and other autoimmune conditions. Researchers use model systems, biorepository samples and clinical studies to understand how immune responses go awry. They also study the gut microbiome and how immune responses in the gut contribute to other autoimmune diseases.

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News Science in Seattle

LITAF Protects Against Pore-Forming Protein–Induced Cell Death by Promoting Membrane Repair: Interview with Drs. Stefani & Lacy-Hulbert

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News American Association of Immunologists AAI

Benaroya Research Institute’s Steven F. Ziegler, PhD, Named 2024 Distinguished Fellow by the American Association of Immunologists

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News American Association of Immunologists AAI

Benaroya Research Institute President Jane Buckner, MD, Receives 2024 American Association of Immunologists’ Steinman Award for Human Immunology Research

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