Ray Lab

Introduction

Genetic variation in the human genome controls a compendium of cellular and physiological components that make up human biology. The Ray Lab is interested in better understanding how genetic variation tunes our immune system and how this can put individuals at risk for autoimmune diseases, which is a vital step in developing more effective therapeutics with fewer side effects. 

Because most genetic risk for autoimmune diseases occurs in non-coding regions of the genome, the Ray lab studies how non-coding genetic variants modulate cis-regulatory regions and alter immune cell activities that lead to autoimmune disease susceptibility. We prioritize likely disease-causal variants and cis-regulatory regions, and, in human and mouse systems, identify variant target genes and pathways and define their functional effects on immune cells.

These studies will inform efforts for personalized therapies and disease prevention.

Ray Lab Inline - Group Photo
John Ray
Assistant Member

John Ray, PhD

Assistant Member; Principal Investigator, Ray Lab; Center for Systems Immunology
View Full Bio
Full-width - BRI Lab Samples 1

Open Position: Research Technician I

The Ray Lab at Benaroya Research Institute (BRI) in Seattle, WA is seeking a highly-motivated Research Technician. The Ray lab intersects immunology and genetics to define genetic mechanisms that drive risk for autoimmune diseases such as lupus, multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, among others.
Apply Now

Lab Members

Max Dippel

Maxwell Dippel

Research Technician, Ray Lab; Center for Systems Immunology
Ingrid Harten

Ingrid Harten, PhD

Staff Scientist, Ray Lab; Center for Systems Immunology
Alex Ho

Alex Ho, PhD

Postdoctoral Research Associate, Ray Lab; Center for Systems Immunology
Meghan McQuade

Meghan McQuade

Research Technician, Ray Lab; Center for Systems Immunology
Leann Nguyen

LeAnn Nguyen, PhD

PostDoctoral Researcher, Ray Lab; Center for Systems Immunology
Amelia Querbach

Amelia Querbach

Lab Aide, Ray Lab; Center for Systems Immunology

Research Projects

Ray Lab Research Project Preview - Defining Variants

Defining variants that act collectively to promote disease

Identifying synergistic properties of variants and enhancers on T cell function
View Project
Ray Lab Research Project Preview - Mapping cis regulatory regions

Mapping cis-regulatory regions that control immune cell function genome-wide

Identifying enhancers that facilitate T and B cell function throughout the genome using CRISPR screening approaches.
View Project
Ray Lab Research Project Preview - Connecting Risk Variants

Prioritizing autoimmune disease-causal variants in immune cells

Utilizing massively parallel reporter assays and statistical fine-mapping to enrich for functional and disease-causal genetic variation
View Project

Related Stories

News NIH New Innovator
January 11, 2024

John Ray, PhD, Receives NIH New Innovator Award

The prestigious NIH Director’s New Innovator Award provides significant funding for innovative research that holds the promise of high rewards. And BRI geneticist John Ray, PhD, just received one.
Read Article
Blog Main Image - 3D Biological Human Kidneys Blue Red
January 9, 2023

Lupus Nephritis: New Approach Could Pave the Way for Innovative Treatments

When Jessica Hamerman, PhD, was perusing research papers in 2021, one discovery stopped her in her tracks — and ultimately put her on a whole new research path.

Read Article
Blog Main Image - BRI Building Rear
December 30, 2022

A Heartfelt Thank You: One Scientist Shares How Donors Make an Impact at BRI

This giving season, on behalf of our team, I extend a heartfelt thank you to all BRI donors and share some of the meaningful ways your philanthropy supports our work.

Read Article

News

News NIH New Innovator

Benaroya Research Institute Immunologist John Ray Receives 2023 NIH Director’s New Innovator Award

Read More
News Science in Seattle

Science in Seattle: Lupus Nephritis: New Approach Could Pave the Way for Innovative Treatments

Read more ➡
News Science in Seattle

Science in Seattle: BRI Advances Understanding of the Link between Genetics and Autoimmune Disease Risk

Read more ➡