Benaroya Research Institute (BRI) is on a mission to predict, prevent, reverse and cure immune system diseases. We study the cells and processes within the immune system, how and why immune system diseases start, and how to rebalance the immune system back to health. Our focus spans a wide variety of immune system diseases – including autoimmune diseases, asthma, allergy, cancer and COVID-19 – with the goal of transforming our understanding of how to prevent and treat these conditions.
Collaboration defines our work. We build teams within our institute and with partners around the world to take on some of the most difficult questions in immunology. This approach moves us closer to our vision of a healthy immune system for everyone.
Our Centers of Discovery: A pipeline from lab research to life-changing care
BRI’s research is organized around four Centers of Discovery, allowing us to accelerate advances at every stage of our work. Our centers enable us to make discoveries in the lab and provide a foundation for new and innovative therapies. They also help us to take questions directly from the clinic — such as what makes a therapy work for one person and not another — back to our labs to find meaningful answers.
Our Biorepositories
BRI is home to 11 biorepositories with thousands of blood and tissue samples that have been donated to science, spanning 20 different immune system diseases as well as healthy controls. Access to human samples allows us to closely study diseases in the lab, make new insights, and bring those insights to patient care faster.
Our Core Labs: Building and using the latest tools and technologies
Our Core Labs enable our scientists to build and use some of the most innovative tools in immunology that allow for advanced imaging, data sequencing and exploring the human genome. Each core is led by an expert in their field. Scientists across BRI and from other institutes can partner with these experts to leverage these tools and fuel discoveries in all areas of research.
Our Team: Together we discover
Collaboration is one of BRI’s core values, and our team is our biggest asset. We have built our organization to facilitate teamwork across disease areas, with experts working across fields and with partners around the globe. Shared resources like our Core Labs, Clinical Research Center and biorepositories fuel discoveries across our institute.
Featured Publications
Jun 2025
Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites
J Allergy Clin Immunol Glob
Thomas Kayser, Ronald Smulders, Tomohiro Kusawake, Erik Wambre, Gurunadh R Chichili, Mary B Blauwet, Anna Spence, Melanie Patton, Rima Tabash, Hannah A DeBerg, Sugandhika Khosa, Philipp Badorrek, Jens M Hohlfeld, Brian C Ferslew
Jun 2025
Long-term outcome of rendezvous internalization treatment for external pancreatic fistulas associated with disconnected pancreatic duct syndrome: a retrospective study
Surg Endosc
Hyung Ku Cho, Richard A Kozarek, Mehran Fotoohi, Shayan S Irani
Jun 2025
Functional dissection of noncoding variants associated with rheumatoid arthritis
Ann Rheum Dis
Ajay Jajodia, Arpit Mishra, Naresh Doni Jayavelu, Katharina Lambert, Nicholas Moss, Zongchen Yang, Karen Cerosaletti, Jane H Buckner , R David Hawkins
Jun 2025
Open access online calculator predicts peanut allergic reactions with high accuracy
J Allergy Clin Immunol Pract
Hanipah Mears, Shriya A Sanghera, Henry T Bahnson, Ru-Xin Foong, Tom Marrs, Helen A Brough, Gideon Lack, George Du Toit, Alexandra F Santos
Jun 2025
Latent EBV enhances the efficacy of anti-CD3 mAb in Type 1 diabetes
Nat Commun
Ana Lledó-Delgado, Paula Preston-Hurlburt, Lauren Higdon, Alex Hu, Eddie James, Noha Lim, S Alice Long, James McNamara, Hai Nguyen, Elisavet Serti, Tomokazu S Sumida, Kevan C Herold
