Ziegler Lab Leadership
Steven F. Ziegler, PhD
Dr. Ziegler graduated with honors from the University of Michigan in 1979, and in 1984 received his PhD in molecular biology from UCLA. Following post-doctoral training at the University of Washington, Dr. Ziegler spent five years as a staff scientist at Immunex, followed by three years as the Director of Immunology/Molecular Biology at Darwin Molecular. He joined the Benaroya Research Institute (BRI) as an Associate Member in 1997. He is currently Director of the Immunology Research Program and Director of Academic Affairs at BRI, and Affiliate Professor in the Immunology Department, University of Washington School of Medicine.
Area of Research
The projects in Dr. Ziegler’s laboratory are focused on the factors that control normal immune regulation, as well as those that contribute to disease development and progression. The laboratory is currently engaged in two areas of investigation: the genes and cell populations that are involved in controlling autoimmune-type responses, and the role of epithelial cytokines (TSLP, IL-25, and IL-33) in the regulation of barrier responses to infection and allergen challenge. Finally, we have also found a novel role for TSLP in the regulation of tumor progression, and have established a program in tumor biology, including metastatic breast cancer, colitis-associated cancer and melanoma.
Yoo, J., Omori, M., Gyarmati, D., Aye, T., Branstatter, D.G., Comeau, M.R., Campbell, D.J., and Ziegler, S.F. (2005). Spontaneous Atopic Dermatitis in Mice Expressing an Inducible Thymic Stromal Lymphopoietin (TSLP) Transgene Specifically in the Skin. J. Exp. Med. 202:541-549.
Zhou, B., Comeau, M.R., De Smedt, T., Liggitt, H.D., Dahl, M.E., Lewis, D.B., Gyarmati, D.,Aye, T., Campbell, D.J., and Ziegler, S.F. (2005). Thymic stromal lymphopoietin as key initiator of allergic airway inflammation in mice. Nature Immunology. 6:1047-1053.
Lopes, J.E.*, Torgerson, T.R.*, Schubert, L.A., Anover, S.D., Ochs, H.D., and Ziegler, S.F. (2006). Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor. J. Immunol. 177:3133-3142.
Omori, M. and Ziegler, S.F. (2007). Induction of IL-4 Expression in CD4+ T cells by Thymic Stromal Lymphopoietin (TSLP). J. Immunol. 178:1396-1404.
Du, J., Huang, C., Zhou, B., and Ziegler, S.F. (2007). Human FOXP3 represses ROR gama-mediated transcriptional activation in an isoform-specific, DNA-binding independent manner. J Immunol. In Press.
Zhou, L., Lopes, J.E., Chong, M.M.W., Ivanov, I.I., Min, R., Victora, G.D., Shen, Y.;Du, J., Rubtsov, Y.P., Rudensky, A.Y., Ziegler, S.F., and Littman, D.R. (2008). TGF-β-induced Foxp3 inhibits Th17 cell differentiation by antagonizing ROR?t function. Nature, 453 (7192), 236-40.
Lee HC, Headley MB, Loo YM, Berlin A, Gale M Jr, Debley JS, Lukacs NW, Ziegler SF. (2012) Thymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infection. J. Allergy Clin Immunol. 130:1187-1196
Bell, BD*, Kitajima, M*, Larson, RP, Stoklasek, TA, Dang, K, Sakamoto, K, Wagner, K.-U, Reizis, B, Hennighausen, L, Ziegler, SF (2013) The transcription factor STAT5 is critical in dendritic cells for the development of T(H)2 but not T(H)1 responses. Nat Immunol. 14:364-71
Huang C, Martin S, Pfleger C, Du J, Buckner JH, Bluestone JA, Riley JL, Ziegler SF. (2013) Cutting Edge: A novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28. J Immunol. 190:4470-4473
Larson RP, Comeau MR, Ziegler SF (2013) Cutting edge: Allergen-specific CD4 T cells respond indirectly to thymic stromal lymphopoietin to promote allergic responses in the skin. J. Immunol. 190:4474-4477.
Hauri-Hohl, M., Zuklys, S., Hollander, G.A., Ziegler S.F. (2014) A regulatory role for TGF-signaling in the establishment and function of the thymic medulla. Nat Immunol 15:554-561
Han, H., Thelen T.D., Comeau M.R., and Ziegler, S.F. (2014) TSLP-mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis. J Clin Invest, 124:5442-5452
Sheih A, Parks WP, Ziegler SF (2016) GM-CSF produced by the airway epithelium is required for sensitization to cockroach allergen. Mucosal Immunol. In Press.
List of Published Work
To view a full list of published work, please visit the National Center for Biotechnology Information library of medicine at pubmed.gov.