We are using a series of cell-specific cre-lox systems to selectively deplete the (Thymic Stromal Lymphopoetin Receptor) TSLPR gene from mature B cells and T cells within the germinal center (GC) microenvironment to determine how TSLPR signaling in these cells impacts overall germinal center function.
In a recent publication, we showed that TSLP receptor signaling in mature B cells limits high-affinity memory B cell differentiation, whereas TSLP receptor signaling on T cells is required for antigen-specific GC B cell responses to immunization.
Moving forward, we will continue to ask how TSLPR signaling impacts the GC-derived plasma cells and memory B cells after immunization.
![Ziegler Res Proj Inline - Regulation of Humoral](/sites/default/files/styles/full_width_image_w_o_cropping_1x/public/2023-05/ziegler-res-proj-inline-regulation-of-humoral.jpg?itok=BJpoks1f)
Additional Research Projects
Discover more research projects from the
Ziegler Lab.
![Ziegler Res Proj Main - FoxP3 Delta](/sites/default/files/styles/horizontal_landing_card_1x/public/2023-05/ziegler-res-proj-prev-foxp3-delta.jpg?itok=8NL2XBt5)
Study of Foxp3ΔExon2-expressing regulatory T cells in humans and mice
Characterization of IgE-mediated photosensitivity in Foxp3ΔExon2-expressing mice
![Ziegler Res Proj Prev - Role of TSLP and IL33](/sites/default/files/styles/horizontal_landing_card_1x/public/2023-05/ziegler-res-proj-prev-role-of-tslp-and-il-33.jpg?itok=Z0UPHQav)
The role of TSLP and IL-33 in tissue homeostasis and inflammation
The Ziegler lab is investigating how TLSP and IL-33 signaling at adventitial sites in the lungs and skin maintain tissue immune homeostasis and regulate inflammation and tissue repair.
![Ziegler Res Proj Prev - Role of TSLPR+ST2](/sites/default/files/styles/horizontal_landing_card_1x/public/2023-05/ziegler-res-proj-prev-role-of-tslpr%2Bst2.jpg?itok=whxeuqqR)
The Role of TSLPR+St2+ Tregs in colorectal cancer
Diagnosis and therapy for colorectal cancer targeting a novel subset of Tregs.