Across multiple tissues, conserved anatomical sites termed adventitial cuffs have been shown to be focal points within tissues for the maintenance of tissue homeostasis and initiation of inflammatory cascades.
Although thymic stromal lymphopoietin (TSLP) and interleukin-33 (IL-33) are best known as alarmin cytokines produced by barrier epithelium, specific populations of adventitial fibroblasts have now also been shown to be important sources of TLSP and IL-33.
We are using in vivo models as well as transcriptomic and epigenomic approaches to understand how TLSP and IL-33 signaling at adventitial sites in the lungs and skin maintain tissue immune homeostasis and regulate type 2 inflammation and tissue repair.
