The goal of the Sound Life Project is to understand immune system diversity and how variation among healthy immune systems may influence responses to infection, vaccination, and other immune challenges.
Conducted in collaboration with Jane Buckner, MD, the Sound Life Project enrolled 100 adults with no known chronic diseases who completed 10 study visits over two years. Participants were enrolled in two age-based cohorts: adults ages 25-35 and adults ages 55-65.
Sound Life Project participants completed extensive surveys about their health history and lifestyle, submitted samples for standard clinical testing and deep immunological profiling at every visit, and completed weekly surveys updating researchers about their travel history and health. These data have enabled researchers to investigate important questions about healthy immune systems.
For example, we showed that healthy adult immune systems maintain stable baseline frequencies of many populations of circulating immune cells. We characterized each participant’s baseline immune profile before examining how it changed following vaccination or laboratory stimulation. These analyses use cytometric and genomic approaches to identify immune characteristics associated with different responses to immune challenges.
Featured Publications
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Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation
Sci Transl MedZiyuan He, Marla C Glass, Pravina Venkatesan, Marie L Feser, Leander Lazaro, Lauren Y Okada, Nhung T T Tran, Yudong D He, Samir Rachid Zaim, Christy E Bennett, Padmapriyadarshini Ravisankar, Elisabeth M Dornisch, Alexandra C Ferrannini, Najeeb A Arishi, Ashley G Asamoah, Saman Barzideh, Lynne A Becker, Elizabeth A Bemis, Jane H Buckner , Christopher E Collora, Megan A L Criley, Kristen Demoruelle M, Chelsie L Fleischer, Jessica Garber, Palak C Genge, Qiuyu Gong, Lucas T Graybuck, Claire E Gustafson, Brian C Hattel, Veronica Hernandez, Alexander T Heubeck, Erin K Kawelo, Upaasana Krishnan, Emma L Kuan, Kristine A Kuhn, Christian M LaFrance, Kevin J Lee, Ruoxin Li, Cara Lord, Regina R Mettey, Laura Moss, Blessing Musgrove, Katherine Hy Nguyen, Andrea Ochoa, Vaishnavi Parthasarathy, Mark-Phillip Pebworth, Chong Pedrick, Tao Peng, Cole G Phalen, Julian Reading, Charles R Roll, Jennifer A Seifert, Marguerite D Siedschlag, Cate Speake, Christopher C Striebich, Tyanna J Stuckey, Elliott G Swanson, Hideto Takada, Tylor Thai, Zachary J Thomson, Nguyen Trieu, Vlad Tsaltskan, Wei Wang, Morgan D A Weiss, Amy Westermann, Fan Zhang, David L Boyle, Ananda W Goldrath, Thomas F Bumol, Xiao-Jun Li, V Michael Holers, Peter J Skene, Adam K Savage, Gary S Firestein, Kevin D Deane, Troy R Torgerson, Mark A Gillespie -
Longitudinally stable T cell function and innate immune activation distinguish healthy adult immunotypes.
Sci Transl MedSmithmyer ME, Hu A, Dufort MJ, Hocking AM, Wiedeman AE, Fasano KJ, Torgerson TR, Skene PJ, Reading J, Li X, Gong Q, Long SA, Lacy-Hulbert A, Gustafson CE, Buckner JH, Speake C, members of the BRI Sound Life Project Team, BRI Sound Life Project Team -
Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults.
bioRxivGong Q, Sharma M, Kuan EL, Glass MC, Chander A, Singh M, Graybuck LT, Thomson ZJ, LaFrance CM, Zaim SR, Peng T, Okada LY, Genge PC, Henderson KE, Dornisch EM, Layton ED, Wittig PJ, Heubeck AT, Mukuka NM, Reading J, Roll CR, Hernandez V, Parthasarathy V, Stuckey TJ, Musgrove B, Swanson E, Lord C, Weiss MDA, Phalen CG, Mettey RR, Lee KJ, Johanneson JB, Kawelo EK, Garber J, Krishnan U, Smithmyer M, Wherry EJ, Vella L, Henrickson SE, Kopp MS, Savage AK, Becker LA, Meijer P, Coffey EM, Goronzy JJ, Speake C, Bumol TF, Goldrath AW, Torgerson TR, Li XJ, Skene PJ, Buckner JH, Gustafson CE -
A simple strategy for sample annotation error detection in cytometry datasets.
Cytometry ASmithmyer ME, Wiedeman AE, Skibinski DAG, Savage AK, Acosta-Vega C, Scheiding S, Gersuk VH, O'Rourke C, Long SA, Buckner JH, Speake C
Additional Research Projects
Evaluating Therapies for Type 1 Diabetes
The Center for Interventional Immunology, directed by Dr. Speake, collaborates with biotechnology and pharmaceutical partners to evaluate promising therapies designed to prevent, delay or treat type 1 diabetes.
Experimental Medicine Studies in Type 1 Diabetes
Dr. Speake leads BRI’s Experimental Medicine Unit, which seeks to understand how emerging therapies influence the immune and metabolic pathways involved in type 1 diabetes.
Understanding Type 1 Diabetes Progression
The Speake Lab analyzes Type 1 Diabetes TrialNet data to better understand how type 1 diabetes develops and improve approaches to monitoring people at risk for the disease.
