Using clinical samples obtained through the Immune Tolerance Network, the Kwok Lab employs second-generation tetramer reagents to sensitively detect and characterize autoreactive CD4+ T cells. Researchers use flow cytometry and RNA sequencing to examine changes in the frequency, phenotype, and transcriptomic profiles of autoreactive CD4+ T cells over the course of type 1 diabetes immunotherapy.
Additional Research Projects
Allergen-Specific CD4+ T Cells in Allergy and Immunotherapy
The Kwok Lab uses class II tetramer reagents to study allergen-specific CD4+ T cells and understand how these cells change during immunotherapy.
CD4+ and CD8+ T Cell Responses to Shingrix Vaccination
The Kwok Lab studies CD4+ and CD8+ T cell responses following Shingrix vaccination to better understand how the vaccine provides long-lasting protection against shingles.
DNA-Barcoded HLA Class II Tetramers
The Kwok Lab is developing DNA-barcoded HLA class II tetramers to analyze the specificity, TCR clonotypes, surface protein expression, and gene expression profiles of antigen-specific CD4+ T cells at single-cell resolution.
