Our group focuses on prediction and prevention of type 1 diabetes (T1D) as well as discovery and validation of biomarkers of disease progression and response to therapy. More than 35 years of this work recently led to the first FDA approved disease modifying therapy to delay the onset of T1D in at risk individuals, setting a precedent for treatment before the clinical appearance of other autoimmune diseases as well.
Our highly collaborative team of clinical and translational investigators, biostatisticians, study coordinators, research nurses and administrative support conducts clinical research and clinical trials. This includes academic multi-center and single site trials as well as investigator initiated and early phase industry sponsored studies. Our clinical research studies include short term interventions with mechanistic outcomes termed EMU or Experimental Medicine Unit studies as well as studies testing novel methods for measures of insulin secretion and immune response. Study participants for clinical research and clinical trials come from the 5 state Pacific Northwest region and are seen for research visits on our Clinical Research Center.

Carla Greenbaum, MD
Research Projects

TrialNet clinical trials in those at risk of type 1 diabetes

Collaborations with Industry Partners to test new T1D therapies

Experimental Medicine Unit studies at BRI

Immune Tolerance Network (ITN) clinical trials in type 1 diabetes
Lab Members

Anna Barash, MSN, RN, CDCES

Emily Batts

Katie Bennett

Kassidy Benoscek

Natalie Clary

Deric Khuat

Rishab Kotak

David Lee

Sandra Lord, MD

Courtney Mills

Sunitha Murali

Bao Ng, DNP, ARNP

Katelyn Orcino

Arielle Pagryzinski

Maia Rabinowitz

Sarah Robinson

Cate Speake, PhD

Jodie Stroeve

William Thornton

Danielle Tom

Corinna Tordillos

Dana VanBuecken, ARNP

Kim Varner

Marlie Wells

Nancy Wickstrom
Featured Publications
Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes.
Commun Biol
Proinflammatory islet antigen reactive CD4 T cells are linked with response to alefacept in type 1 diabetes.
JCI Insight
OGTT metrics surpass continuous glucose monitoring data for T1D prediction in multiple-autoantibody-positive individuals.
J Clin Endocrinol Metab
Approval of teplizumab: implications for patients.
Nat Rev Endocrinol
Association between primary graft function and 5-year outcomes of islet allogeneic transplantation in type 1 diabetes: a retrospective, multicentre, observational cohort study in 1210 patients from the Collaborative Islet Transplant Registry.
Lancet Diabetes Endocrinol

Prediction and Prevention: A New Paradigm in Autoimmune Disease

Teplizumab FAQ: Your Questions Answered About New Therapy to Delay T1D
Scientists at the Benaroya Research Institute (BRI) and TrialNet, a global type 1 diabetes (T1D) research consortium, have spent decades working to answer a bold question: Can we stop T1D before it starts?

Beyond Insulin: Beyond BRI's Quest to Stop Type 1 Diabetes
The discovery of insulin 100 years ago transformed type 1 diabetes (T1D) from a death sentence to a chronic illness. Yet T1D is still a relentless disease with no cure.

Benaroya Research Institute’s Dr. Carla Greenbaum Receives Puget Sound Business Journal Lifetime Achievement Award
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Science in Seattle: Characterizing T Cell Responses to Enzymatically Modified Beta Cell Neo-Epitopes
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