Carmen Mikacenic, MD
Background Information
Dr. Carmen Mikacenic received her BS in Biochemistry from Tufts University in Medford, MA and her MD from the University of Washington School of Medicine. She did residency training in internal medicine at Brigham and Women’s Hospital in Boston, MA followed by fellowship in pulmonary and critical care at the University of Washington. She trained under the mentorship of Dr. Wurfel studying immune mechanisms in critical care and interstitial lung disease. She was a faculty member at the University of Washington rising to Associate Professor. Her interest in regulatory T cells and high parameter immunophenotyping led her to successful collaborations with the BRI. She joined the faculty in 2020 and is currently an Associate Member of the Translational Immunology group.
Area of Research
Dr. Mikacenic’s lab is a translational immunology lab focused on discovering immune mechanisms of organ dysfunction in critical illness, particularly Acute Respiratory Distress Syndrome (ARDS). She also studies lung inflammation in the context of interstitial lung diseases with a specific focus on autoimmune associated lung disease and sarcoidosis.
Featured Publications
Bhatraju PK, Ghassemieh BJ, Nichols M, Kim R, Jerome KR, Nalla AK, Greninger AL, Pipavath S, Wurfel MM, Evans L, Kritek PA, West TE, Luks A, Gerbino A, Dale CR, Goldman JD, O'Mahony S, Mikacenic C. Covid-19 in Critically Ill Patients in the Seattle Region - Case Series. N Engl J Med. 2020 Mar 30. doi: 10.1056/NEJMoa2004500. PMID: 32227758
Morrell ED, Wiedeman A, Long SA, Gharib SA, West TE, Skerrett S, Wurfel MM, Mikacenic C. Cytometry Time-of-Flight Identifies Alveolar Macrophage Subtypes in Acute Respiratory Distress Syndrome. JCI Insight. 2018 May 17;3(10). pii: 99281. doi: 10.1172/jci.insight.99281. PMID 29769438.
Mikacenic C, Schneider A, Radella F, Buckner JH, Wurfel MM. Cutting Edge: Genetic Variation in TLR1 is Associated with Pam3CSK4-Induced Effector T Cell Resistance to Regulatory T Cell Suppression. Journal of Immunology, 2014; 193 (12): 5786-90. PMID:25378593.
Mikacenic C, Hansen EE, Radella F, Gharib SA, Stapleton RD, Wurfel MM. IL-17A is Associated with Alveolar Inflammation and Poor Outcomes in Acute Respiratory Distress Syndrome. Crit Care Med. 2016 Mar;44(3):496-502. PMID: 26540401.