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A unified hypothesis for the complex genetics of HLA associations with IDDM.
DiabetesNepom GT -
Retroviral-mediated gene transfer of the leukocyte integrin CD18 subunit.
Biochem Biophys Res CommunBack AL, Kwok WW, Adam M, Collins SJ, Hickstein DD -
HLA and type I diabetes.
Immunol TodayNepom GT -
Nonprogression of subclinical beta-cell dysfunction among first-degree relatives of IDDM patients. 5-yr follow-up of the Seattle Family Study.
DiabetesMcCulloch DK, Klaff LJ, Kahn SE, Schoenfeld SL, Greenbaum CJ, Mauseth RS, Benson EA, Nepom GT, Shewey L, Palmer JP -
Molecular biology of immune diseases and the immune response.
Immunol TodayNepom GT -
Further DNA sequence microheterogeneity of the HLA-DR4/Dw13 haplotype group: importance of amino acid position 86 of the DR beta 1 chain for T-cell recognition.
Hum ImmunolLang B, Navarrete C, LoGalbo PR, Nepom GT, Silver J, Winchester RJ, Gregersen PK -
HLA heterozygosity in insulin-dependent diabetes is most frequent at the DQ locus.
Scand J ImmunolMichelsen B, Wassmuth R, Ludvigsson J, Lernmark A, Nepom GT, Fisher L -
HLA-DQ beta sequence polymorphism and genetic susceptibility to IDDM.
DiabetesErlich HA, Bugawan TL, Scharf S, Nepom GT, Tait B, Griffith RL -
Polymorphic DQ alpha and DQ beta interactions dictate HLA class II determinants of allo-recognition.
J Exp MedKwok WW, Mickelson E, Masewicz S, Milner EC, Hansen J, Nepom GT -
Mutagenesis and expression of putative class II susceptibility genes: a "reverse immunogenetics" approach to analysis of HLA and disease.
AutoimmunityNepom GT -
A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis.
Proc Natl Acad Sci U S ABegovich AB, Bugawan TL, Nepom BS, Klitz W, Nepom GT, Erlich HA -
A genetically controlled pairing anomaly between HLA-DQ alpha and HLA-DQ beta chains.
J ImmunolKwok WW, Thurtle P, Nepom GT -
Determinants of genetic susceptibility in HLA-associated autoimmune disease.
Clin Immunol ImmunopatholNepom GT -
The effects of variations in human immune-response genes.
N Engl J MedNepom GT -
The benzodiazepine receptor ligands RO 5-4864 and RO 15-1788 do not block the inhibition of PAF-induced platelet aggregation seen with the hetrazepine WEB2086
Biochem Biophys Res CommunGriffin K, Hong T, Levy JV
