At this point, we’ve lived through many phases of the pandemic: closing schools and sanitizing surfaces. Mask mandates and mRNA vaccines. Now, we’ve reached a new phase, with still more questions: How dangerous is the Delta variant? And will our vaccines keep protecting us as the virus changes?

BRI’s Adam Lacy-Hulbert, PhD, recently answered key questions and shared his insight on the current state of COVID-19.

1.  I’ve been hearing about booster shots. What does a COVID-19 booster shot do?

Adam-Lacy-Hulbert-PhD-smiling-in-labA booster shot is an additional shot you get months or years after first getting a vaccine. It helps your body remember what a germ looks like and how to fight it off.

Vaccines teach your immune system’s T cells how to recognize an invader and teach your B cells how to fight off that invader. When you get a vaccine, your body makes millions of B and T cells. Some of these cells die down shortly after the shot. But some cells stick around and become “memory cells.”

“These cells give your immune system a long-term memory of that germ, so when you see it again, they’re ready to respond,” Dr. Lacy-Hulbert says.“ You’ve probably heard a million times when you’re outside and get a cut, and someone says ‘when did you last have a tetanus shot?’ We’re recommended to get that shot every few years to boost that immune response, to make sure those immune memory cells are still there.” 

The other reason you might need a booster shot is that a germ adapts and starts to look a little different over time.

“You get a flu shot every year because the flu virus changes every year,” Dr. Lacy-Hulbert says. “The booster amplifies your immune response and retrains your immune system to know what the new flu looks like.”

2. Do we need booster shots for COVID-19?

Sandra-Lord-PhDThe Biden administration recently announced that most Americans should receive a booster shot eight months after their first COVID-19 vaccine. This decision stems from data in Israel that shows declining protection from the vaccine around eight months after getting the shot. Scientists, including those at BRI, are working to learn more about this potential decline, how boosters might help and when would be the best time to administer them. The FDA has not yet approved booster shots.

BRI participated in the phase 3 Pfizer COVID-19 vaccine study that led to emergency approval of the Pfizer-BioNTech vaccine in December 2020. A subset of participants from that study volunteered again this past summer to test a 3rd dose or booster of the Pfizer vaccine. Participants were randomly assigned to receive either placebo or active vaccine. The one-year booster study, led by Sandra Lord, MD, will compare antibody levels and rates of COVID-19 illness in the two groups.

“This comparison will help to better understand if protection from the virus is declining and, if so, when that starts to happen,” Dr. Lord says. “The goal is to figure out how much time it takes before you see a difference between boosted and unboosted populations. That will help us learn more about when you might need a booster.”

3. How do virus variants happen?

Virus variants happen when a virus reproduces and spreads. Viruses spread by making copies of themselves and their genetic code. But sometimes when they make those copies, they make typos called “mutations.”

“Virus variants happen in the same way humans evolved from Neanderthals — when we reproduce, we see these tiny changes in genetic code,” Dr. Lacy-Hulbert says. “Sometimes those changes help us survive, like having thumbs or walking upright. Individuals with those mutations survive better, reproduce, and pass on those genetic traits.” 

The more the virus spreads, the more opportunities it has to reproduce and change. That’s how new variants arise.

“Every time that the virus gets copied, a few little errors might creep in,” Dr. Lacy-Hulbert says. “That means that every time it goes through an infection, you might get a slightly different version of the virus coming out of each cell. And when one of those versions has an advantage over another — say it’s more contagious — that variant lives on.” 

4. What is the delta variant?

The delta variant is one of four COVID-19 variants being monitored in the United States as of publication in August 2021. It was first identified in India in December 2020 and first found in the United States in March 2021. This variant appears to spread more quickly and easily than other variants. 

5. Is the Delta variant more contagious? Is the delta variant more dangerous?

The Delta variant has some mutations in the genetic code that make it more contagious than the earlier variants. People who test positive for the Delta variant have more virus particles in their airways, which makes it spread more easily.

“We’ve yet to see any convincing data that Delta is a lot more deadly — that it's making people a lot sicker,” Dr. Lacy-Hulbert says. “It's definitely more contagious which is probably why there are so many hospitalizations and severe cases right now.”

6. Are current vaccines effective against variants? Are scientists making vaccines to target variants?

The vaccines are effective against current variants of COVID-19. The vast majority of people experiencing severe disease are unvaccinated. It's still possible for vaccinated people to get infected, but vaccines dramatically reduce the risk of serious illness that leads to hospitalization or death.

Scientists are also actively conducting research to create vaccines specifically targeted to COVID-19 variants.

7. Could COVID-19 mutate to evade vaccines?

Current vaccines target a key part of the virus called a spike protein, which allows the virus to enter your cells. The vaccines are a little less effective at preventing infection by some variants which have mutations in the spike protein. However, so far there are no variants that completely evade the vaccines. 

“The vaccine targets an interaction that’s essential for the virus to infect your cells and spread through your body,” Dr. Lacy-Hulbert says. “Mutations can make vaccines slightly less effective. But it would be very difficult for the virus to mutate enough to evade the vaccine’s protection entirely.” 

8. What is a breakthrough COVID-19 case? Why are there breakthrough cases of COVID-19?

A breakthrough case happens when someone tests positive for COVID-19 even though they’ve been vaccinated. Most people who experience breakthrough COVID-19 cases have mild illness and some have no symptoms at all.

“The vaccine is very good at stopping COVID-19 from spreading through your body and getting severe symptoms, but it doesn’t stop the virus from getting into your nose and lungs,” Dr. Lacy-Hulbert says. “When we test for COVID-19, we’re testing whether there’s any virus in your airway. When we hear about breakthrough infections, we’re often talking about people who have the virus in their airways and test positive, but these are not typically people who are getting really sick.”

9. Can vaccinated people spread the virus?

Scientists are still working to answer this question, but research suggests that they can. One study of a COVID-19 outbreak in Massachusetts found that vaccinated people infected with COVID-19 had similar levels of virus as unvaccinated people, which led scientists to believe they can spread the virus. Very few of those vaccinated individuals experienced severe illness. Other studies are working to learn more about the virus’ spread among vaccinated people.

“When we create vaccines, our first goal is to stop people from getting sick and dying, and COVID-19 vaccines are certainly doing that,” Dr. Lacy-Hulbert says. “The second goal is to stop people from spreading infection. The vaccine does that, but maybe not as well as we originally hoped.”

10. Have scientists learned more about potential side effects or long-term effects of taking these vaccines?

Early scientific findings hold true for our COVID-19 vaccines: they are safe and highly effective. The Pfizer/ BioNTech mRNA vaccine has now received full approval from the FDA.

“Initial studies looked at thousands of people and showed few side effects. Now, mRNA vaccines have been given to millions and millions of people, some people have been vaccinated for a year now. And we still haven’t seen any major side effects,” Dr. Lacy-Hulbert says.

11. How can I continue to protect myself and my family from COVID-19?

The best way to protect yourself and family from COVID-19 is to get vaccinated and to encourage people in your community to get vaccinated.

“A lot of studies show that we’ve reached the point where doctors and the government saying, ‘get the vaccine!’ has reached its limit,” Dr. Lacy-Hulbert says. “The people who need convincing now are going to be convinced by personal connections — family, friends and trusted people in their communities. So you can be an advocate for the vaccine. Reach out and help people get the vaccine. Offer them a ride or child care or whatever might make it easier.”

Continuing to wear a mask indoors and in crowded settings is also a key way to stay safe.

“A lot of us are thinking at this point ‘we’ve done our bit, we’ve got the vaccine’ but we’re still seeing infections,” Dr. Lacy-Hulbert says. “One of the easiest things you can do to slow the spread is wearing a mask while indoors — at stores, schools, gyms. It really helps keep everyone safe.”

Find answers to more pressing questions from BRI researchers: Learn 11 key facts about mRNA vaccines and understand exactly what it means to be immunocompromised.

Category: 
News & Views

September 14, 2021

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