Estelle Bettelli, PhD
Background Information
Dr. Bettelli received her BS in Cellular Biology from the University Pierre et Marie Currie (Paris 6) in 1995 and her PhD in Hematology/Immunology from the University Denis Diderot (Paris 7) in 2001. Following a postdoctoral fellowship and after serving as an Instructor in the Department of Neurology at the Brigham and Women’s Hospital, Boston, she served as an Assistant Professor at Harvard Medical School. Dr. Bettelli joined the faculty of the Benaroya Research Institute in 2009 and is currently and Associate Member. She is also an Affiliate Associate Professor in the Department of Immunology at the University of Washington School of Medicine.
Area of Research
The focus of the Bettelli Laboratory is to identify pathogenic immune cells which drive the development of autoimmunity, determine how they are generated and how they can be regulated in order to limit the progression and prevent the development of autoimmunity.
Featured Publications
Glatigny S, Höllbacher B, Motley SJ, Tan C, Hundhausen C, Buckner JH, Smilek D, Khoury SJ, Ding L, Qin T, Pardo J, Nepom GT, Turka LA, Harris KM, Campbell DJ, Bettelli E. Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance. J Immunol. 2019 Mar 1;202(5):1373-1382. doi: 10.4049/jimmunol.1801425. Epub 2019 Jan 25. PubMed PMID: 30683697; PubMed Central PMCID: PMC6481683.
Oukka M, Bettelli E. Regulation of lymphocyte trafficking in central nervous system autoimmunity. Curr Opin Immunol.2018 Dec;55:38-43. doi: 10.1016/j.coi.2018.09.008. Epub 2018 Sep 27. Review. PubMed PMID: 30268837; PubMed Central PMCID: PMC6286213.
Eken A, Duhen R, Singh AK, Fry M, Buckner JH, Kita M, Bettelli E, Oukka M. S1P1 deletion differentially affects TH17 and Regulatory T cells. Sci Rep. 2017 Oct 10;7(1):12905. doi: 10.1038/s41598-017-13376-2. PubMed PMID: 29018225; PubMed Central PMCID: PMC5635040.
Singh AK, Eken A, Hagin D, Komal K, Bhise G, Shaji A, Arkatkar T, Jackson SW, Bettelli E, Torgerson TR, Oukka M. DOCK8 regulates fitness and function of regulatory T cells through modulation of IL-2 signaling. JCI Insight. 2017 Oct 5;2(19). doi: 10.1172/jci.insight.94275. PubMed PMID: 28978795; PubMed Central PMCID: PMC5841873.
Glatigny S, Wagner CA, Bettelli E. Cutting Edge: Integrin α4 Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis. J Immunol. 2016 May 1;196(9):3542-6. doi: 10.4049/jimmunol.1502614. Epub 2016 Mar 25. PubMed PMID: 27016608; PubMed Central PMCID: PMC4868662.
Arbelaez CA, Glatigny S, Duhen R, Eberl G, Oukka M, Bettelli E. IL-7/IL-7 Receptor Signaling Differentially Affects Effector CD4+ T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis. J Immunol. 2015 Sep 1;195(5):1974-83.
Glatigny S, Duhen R, Arbelaez C, Kumari S, Bettelli E. Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4. Sci Rep. 2015 Jan 16;5:7834.
Peters A, Burkett PR, Sobel RA, Buckley CD, Watson SP, Bettelli E, Kuchroo VK. Podoplanin negatively regulates CD4+ effector T cell responses. J Clin Invest. 2015 Jan;125(1):129-40. doi: 10.1172/JCI74685. Epub 2014 Nov 21. PubMed PMID: 25415436; PubMed Central PMCID: PMC4382244.
Singh AK, Eken A, Fry M, Bettelli E, Oukka M. DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs. Nat Commun. 2014 Aug 5;5:4603.
Duhen R, Glatigny S, Arbelaez CA, Blair TC, Oukka M, Bettelli E. Cutting Edge: The Pathogenicity of IFN-γ-Producing Th17 Cells Is Independent of T-bet. J Immunol. 2013 Mar 29;190(9):4478-82.
Peters A, Pitcher LA, Sullivan JM, Mitsdoerffer M, Acton SE, Franz B, Wucherpfennig K, Turley S, Carroll MC, Sobel RA, Bettelli E, Kuchroo VK. Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity. 2011 Dec 23;35(6):986-96.
Glatigny S, Duhen R, Oukka M, Bettelli E. Cutting edge: loss of α4 integrin expression differentially affects the homing of Th1 and Th17 cells. J Immunol. 2011 Dec 15;187(12):6176-9.
Mitsdoerffer M, Lee Y, Jäger A, Kim HJ, Korn T, Kolls JK, Cantor H, Bettelli E, Kuchroo VK. Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14292-7.
Awasthi A, Riol-Blanco L, Jäger A, Korn T, Pot C, Galileos G, Bettelli E, Kuchroo VK, Oukka M. Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells. J Immunol. 2009 May 15;182(10):5904-8.
Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, Oukka M, Kuchroo VK. IL-21 initiates an alternate pathway to induce proinflammatory Th17 cells. Nature. 2007; 448:484-7.
Bettelli E, Baeten D, Jager A, Sobel RA, Kuchroo VK. Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice. J Clin Invest. 2006;116:2393-2402.
Bettelli E, Carrier Y., Gao W, Korn T., Strom T., Oukka M., Weiner H.L., Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector (Th-IL-17) and regulatory (CD4+CD25+, Foxp3+) T cells. Nature. 2006;441:235-8.
Bettelli E, Sullivan B, Szabo SJ, Sobel RA, Glimcher LH, Kuchroo VK. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med. 2004 Jul 5;200(1):79-87. doi: 10.1084/jem.20031819. PubMed PMID: 15238607; PubMed Central PMCID: PMC2213316.
Bettelli E, Pagany M, Weiner HL, Linington C, Sobel RA, Kuchroo VK. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med. 2003 May 5;197(9):1073-81. doi: 10.1084/jem.20021603. PubMed PMID: 12732654; PubMed Central PMCID: PMC2193967.
List of Published Work
To view a full list of published work, please visit the National Center for Biotechnology Information library of medicine at pubmed.gov.