Estelle Bettelli, PhD
Dr. Bettelli received her BS in Cellular Biology from the University Pierre et Marie Currie (Paris 6) in 1995 and her PhD in Hematology/Immunology from the University Denis Diderot (Paris 7) in 2001. Following a postdoctoral fellowship and after serving as an Instructor in the Department of Neurology at the Brigham and Women’s Hospital, Boston, she served as an Assistant Professor at Harvard Medical School. Dr. Bettelli joined the faculty of the Benaroya Research Institute as an Assistant Member in 2009. She is also an Affiliate Assistant Professor in the Department of Immunology at the University of Washington School of Medicine.
Area of Research
The focus of the Bettelli Laboratory is to identify pathogenic immune cells which drive the development of autoimmunity, determine how they are generated and how they can be regulated in order to limit the progression and prevent the development of autoimmunity.
Arbelaez CA, Glatigny S, Duhen R, Eberl G, Oukka M, Bettelli E. IL-7/IL-7 Receptor Signaling Differentially Affects Effector CD4+ T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis. J Immunol. 2015 Sep 1;195(5):1974-83.
Glatigny S, Duhen R, Arbelaez C, Kumari S, Bettelli E. Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4. Sci Rep. 2015 Jan 16;5:7834.
Singh AK, Eken A, Fry M, Bettelli E, Oukka M. DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs. Nat Commun. 2014 Aug 5;5:4603.
Duhen R, Glatigny S, Arbelaez CA, Blair TC, Oukka M, Bettelli E. Cutting Edge: The Pathogenicity of IFN-γ-Producing Th17 Cells Is Independent of T-bet. J Immunol. 2013 Mar 29;190(9):4478-82.
Peters A, Pitcher LA, Sullivan JM, Mitsdoerffer M, Acton SE, Franz B, Wucherpfennig K, Turley S, Carroll MC, Sobel RA, Bettelli E, Kuchroo VK. Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity. 2011 Dec 23;35(6):986-96.
Glatigny S, Duhen R, Oukka M, Bettelli E. Cutting edge: loss of α4 integrin expression differentially affects the homing of Th1 and Th17 cells. J Immunol. 2011 Dec 15;187(12):6176-9.
Mitsdoerffer M, Lee Y, Jäger A, Kim HJ, Korn T, Kolls JK, Cantor H, Bettelli E, Kuchroo VK. Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14292-7.
Jäger A, Dardalhon V, Sobel RA, Bettelli E, Kuchroo VK. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J Immunol. 2009 Dec 1;183(11):7169-77.
Awasthi A, Riol-Blanco L, Jäger A, Korn T, Pot C, Galileos G, Bettelli E, Kuchroo VK, Oukka M. Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells. J Immunol. 2009 May 15;182(10):5904-8.
Frommer F, Heinen TJ, Wunderlich FT, Yogev N, Buch T, Roers A, Bettelli E, Müller W, Anderton SM, Waisman A. Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. J Immunol. 2008 Oct 15;181(8):5748-59.
Bettelli E, Korn T. Oukka M, Kuchroo VK. Th17 cells: Induction and effector functions. Nature. 2007; 453:1051-7.
Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol. 2007;8:345-50.
Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, Oukka M, Kuchroo VK. IL-21 initiates an alternate pathway to induce proinflammatory Th17 cells. Nature. 2007; 448:484-7.
Bettelli E, Korn T, Kuchroo VK. Th17: the third member of the effector T cell Trilogy. Curr. Opin. Immunol. 2007;19(6):652-7.
Bettelli E, Carrier Y., Gao W, Korn T., Strom T., Oukka M., Weiner H.L., Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector (Th-IL-17) and regulatory (CD4+CD25+, Foxp3+) T cells. Nature. 2006;441:235-8.
Bettelli E, Baeten D, Jager A, Sobel RA, Kuchroo VK. Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice. J Clin Invest. 2006;116:2393-2402.