Benaroya Research Institute (BRI) is on a mission to predict, prevent, reverse and cure immune system diseases. We study the cells and processes within the immune system, how and why immune system diseases start, and how to rebalance the immune system back to health. Our focus spans a wide variety of immune system diseases – including autoimmune diseases, asthma, allergy and cancer – with the goal of transforming our understanding of how to prevent and treat these conditions.
Collaboration defines our work. We build teams within our institute and with partners around the world to take on some of the most difficult questions in immunology. This approach moves us closer to our vision of a healthy immune system for everyone.
Our Centers of Discovery: A pipeline from lab research to life-changing care
BRI’s research is organized around four Centers of Discovery, allowing us to accelerate advances at every stage of our work. Our centers enable us to make discoveries in the lab and provide a foundation for new and innovative therapies. They also help us to take questions directly from the clinic — such as what makes a therapy work for one person and not another — back to our labs to find meaningful answers.
Our Biorepositories
BRI is home to 11 biorepositories with thousands of blood and tissue samples that have been donated to science, spanning 20 different immune system diseases as well as healthy controls. Access to human samples allows us to closely study diseases in the lab, make new insights, and bring those insights to patient care faster.
Our Core Labs: Building and using the latest tools and technologies
Our Core Labs enable our scientists to build and use some of the most innovative tools in immunology that allow for advanced imaging, data sequencing and exploring the human genome. Each core is led by an expert in their field. Scientists across BRI and from other institutes can partner with these experts to leverage these tools and fuel discoveries in all areas of research.
Our Team: Together we discover
Collaboration is one of BRI’s core values, and our team is our biggest asset. We have built our organization to facilitate teamwork across disease areas, with experts working across fields and with partners around the globe. Shared resources like our Core Labs, Clinical Research Center and biorepositories fuel discoveries across our institute.
Featured Publications
Sep 2025
Profiling associations of interactive ligand-receptors (HLA class I and KIR gene products) with the progression to type 1 diabetes among seroconverted participants
Diabetologia
Lue Ping Zhao, George K Papadopoulos , Benjamin J McFarland, Jay S Skyler, Hemang M Parikh, William W Kwok, Terry P Lybrand, George P Bondinas, Antonis K Moustakas, Ruihan Wang , Chul-Woo Pyo , Wyatt C Nelson , Daniel E Geraghty, Åke Lernmark
Sep 2025
Screening Lessons from Prediction and Prevention of Type 1 Diabetes
Inflamm Bowel Dis
Cate Speake, Adam Lacy-Hulbert, James Lord, Carla Greenbaum
Sep 2025
TSLP: contrasting roles in cancer
Front Immunol
Remo Poto, Gianni Marone, Steven F Ziegler , Gilda Varricchi
Sep 2025
Loss of the actin remodeling protein Flightless-1 impairs CD8 and regulatory T cell function
bioRxiv
Michelle M Lissner, Jenna M Sullivan, Minjian Ni, McKenna Sherve, Anne M Hocking, Jessica A Hamerman, Daniel J Campbell
Aug 2025
cytoKernel: robust kernel embeddings for assessing differential expression of single-cell data
Bioinformatics
Tusharkanti Ghosh, Ryan M Baxter, Souvik Seal, Victor G Lui, Pratyaydipta Rudra, Thao Vu, Elena W Y Hsieh, Debashis Ghosh