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TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4+ T cells.
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The binding of antigenic peptides to HLA-DR is influenced by interactions between pocket 6 and pocket 9.
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Incident dysglycemia and progression to type 1 diabetes among participants in the Diabetes Prevention Trial-Type 1.
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Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells.
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Thymic stromal lymphopoietin and the pathophysiology of atopic disease.
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Changes in autoreactive T cell avidity during type 1 diabetes development.
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CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta.
Journal of ImmunologyBollyky PL, Falk BA, Long SA, Preisinger A, Braun KR, Wu RP, Evanko SP, Buckner JH, Wight TN, Nepom GT -
Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti-factor VIII immune responses.
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Remodeling rodent models to mimic human type 1 diabetes.
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Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years.
Clinical ImmunologyHerold KC, Gitelman S, Greenbaum CJ, Puck J, Hagopian WA, Gottlieb PA, Sayre PH, Bianchine PJ, Wong E, Seyfert-Margolis V, Bourcier K, Bluestone JA, Immune Tolerance Network ITN007AI Study Group. -
Cutaneous chronic graft-versus-host disease does not have the abnormal endothelial phenotype or vascular rarefaction characteristic of systemic sclerosis.
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Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms.
Journal of ImmunologyGebe JA, Yue BB, Unrath KA, Falk BA, Nepom GT -
The effect of age on insulin sensitivity and insulin secretion in first-degree relatives of type 1 diabetic patients: a population analysis.
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H5N1 strain-specific hemagglutinin CD4+ T cell epitopes restricted by HLA DR4.
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Narcolepsy is strongly associated with the T-cell receptor alpha locus.
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