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Overall sulfation of heparan sulfate from pancreatic islet β-TC3 cells increases maximal fibril formation but does not determine binding to the amyloidogenic peptide islet amyloid polypeptide.
The Journal of Biological ChemistryHull RL, Peters MJ, Perigo SP, Chan CK, Wight TN, Kinsella MG -
The role of hyaluronan and the extracellular matrix in islet inflammation and immune regulation.
Curr Diab RepBollyky PL, Bogdani M, Bollyky JB, Hull RL, Wight TN -
Hyaluronan and hyaluronan binding proteins are normal components of mouse pancreatic islets and are differentially expressed by islet endocrine cell types.
J Histochem CytochemHull RL, Johnson PY, Braun KR, Day AJ, Wight TN -
A functional framework for interpretation of genetic associations in T1D.
Current Opinion in ImmunologyNepom GT, Buckner JH -
Thymic stromal lymphopoietin and allergic disease.
The Journal of Allergy and Clinical ImmunologyZiegler SF -
HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term.
Journal of VirologyVingert B, Benati D, Lambotte O, de Truchis P, Slama L, Jeannin P, Galperin M, Perez-Patrigeon S, Boufassa F, Kwok WW, Lemaître F, Delfraissy JF, Thèze J, Chakrabarti LA -
T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2.
ImmunityKoch MA, Thomas KR, Perdue NR, Smigiel KS, Srivastava S, Campbell DJ -
Systematic localization of common disease-associated variation in regulatory DNA.
ScienceMaurano MT, Humbert R, Rynes E, Thurman RE, Haugen E, Wang H, Reynolds AP, Sandstrom R, Qu H, Brody J, Shafer A, Neri F, Lee K, Kutyavin T, Stehling-Sun S, Johnson AK, Canfield TK, Giste E, Diegel M, Bates D, Hansen RS, Neph S, Sabo PJ, Heimfeld S, Raubitschek A, Ziegler S, Cotsapas C, Sotoodehnia N, Glass I, Sunyaev SR, Kaul R, Stamatoyannopoulos JA, Ziegler SF -
Type-1 immunity drives early lethality in scurfy mice.
Eur J ImmunolSuscovich TJ, Perdue NR, Campbell DJ -
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function.
DiabetesLong SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, Ahmann A, Rabinovitch A, Aggarwal S, Phippard D, Turka LA, Ehlers MR, Bianchine PJ, Boyle KD, Adah SA, Bluestone JA, Buckner JH, Greenbaum CJ, Diabetes TrialNet and the Immune Tolerance Network. -
Compartmentalized control of skin immunity by resident commensals.
ScienceNaik S, Bouladoux N, Wilhelm C, Molloy MJ, Salcedo R, Kastenmuller W, Deming C, Quinones M, Koo L, Conlan S, Spencer S, Hall JA, Dzutsev A, Kong H, Campbell DJ, Trinchieri G, Segre JA, Belkaid Y -
Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide.
American Journal of Respiratory Cell and Molecular BiologyTanino Y, Chang MY, Wang X, Gill SE, Skerrett S, McGuire JK, Sato S, Nikaido T, Kojima T, Munakata M, Mongovin S, Parks WC, Martin TR, Wight TN, Frevert CW -
Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet data.
DiabetesGreenbaum CJ, Beam CA, Boulware D, Gitelman SE, Gottlieb PA, Herold KC, Lachin JM, McGee P, Palmer JP, Pescovitz MD, Krause-Steinrauf H, Skyler JS, Sosenko JM, Type 1 Diabetes TrialNet Study Group. -
Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis.
Arthritis and RheumatismSnir O, Bäcklund J, Boström J, Andersson I, Kihlberg J, Buckner JH, Klareskog L, Holmdahl R, Malmström V -
The application of the diabetes prevention trial-type 1 risk score for identifying a preclinical state of type 1 diabetes.
Diabetes CareSosenko JM, Skyler JS, Mahon J, Krischer JP, Beam CA, Boulware DC, Greenbaum CJ, Rafkin LE, Cowie C, Cuthbertson D, Palmer JP, Type 1 Diabetes TrialNet Study Group., Diabetes Prevention Trial-Type 1 Study Group.
