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Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study.
DiabetesSeyfert-Margolis V, Gisler TD, Asare AL, Wang RS, Dosch HM, Brooks-Worrell B, Eisenbarth GS, Palmer JP, Greenbaum CJ, Gitelman SE, Nepom GT, Bluestone JA, Herold KC -
DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.
Proc Natl Acad Sci U S ADurinovic-Belló I, Rosinger S, Olson JA, Congia M, Ahmad RC, Rickert M, Hampl J, Kalbacher H, Drijfhout JW, Mellins ED, Al Dahouk S, Kamradt T, Maeurer MJ, Nhan C, Roep BO, Boehm BO, Polychronakos C, Nepom GT, Karges W, McDevitt HO, Sønderstrup G -
Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide.
J Exp MedSteere AC, Klitz W, Drouin EE, Falk BA, Kwok WW, Nepom GT, Baxter-Lowe LA -
Association of tumor necrosis factor alpha polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort.
Arthritis RheumKhanna D, Wu H, Park G, Gersuk V, Gold RH, Nepom GT, Wong WK, Sharp JT, Reed EF, Paulus HE, Tsao BP, Western Consortium of Practicing Rheumatologists. -
Allelic variation in key peptide-binding pockets discriminates between closely related diabetes-protective and diabetes-susceptible HLA-DQB1*06 alleles.
J ImmunolEttinger RA, Papadopoulos GK, Moustakas AK, Nepom GT, Kwok WW -
Lost in translation: barriers to implementing clinical immunotherapeutics for autoimmunity.
J Exp Medvon Herrath MG, Nepom GT -
The insulin A-chain epitope recognized by human T cells is posttranslationally modified.
J Exp MedMannering SI, Harrison LC, Williamson NA, Morris JS, Thearle DJ, Jensen KP, Kay TW, Rossjohn J, Falk BA, Nepom GT, Purcell AW -
Targeting T lymphocytes for immune monitoring and intervention in autoimmune diabetes.
Am J TherMallone R, Nepom GT -
Functional avidity directs T-cell fate in autoreactive CD4+ T cells.
BloodMallone R, Kochik SA, Reijonen H, Carson B, Ziegler SF, Kwok WW, Nepom GT -
De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells.
Proc Natl Acad Sci U S AWalker MR, Carson BD, Nepom GT, Ziegler SF, Buckner JH -
Tetramer analysis of human autoreactive CD4-positive T cells.
Adv ImmunolNepom GT -
Inhibition of altered peptide ligand-mediated antagonism of human GAD65-responsive CD4+ T cells by non-antagonizable T cells.
Eur J ImmunolGebe JA, Masewicz SA, Kochik SA, Reijonen H, Nepom GT -
Interaction between RANKL and HLA-DRB1 genotypes may contribute to younger age at onset of seropositive rheumatoid arthritis in an inception cohort.
Arthritis RheumWu H, Khanna D, Park G, Gersuk V, Nepom GT, Wong WK, Paulus HE, Tsao BP -
Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles.
J ImmunolShams H, Klucar P, Weis SE, Lalvani A, Moonan PK, Safi H, Wizel B, Ewer K, Nepom GT, Lewinsohn DM, Andersen P, Barnes PF -
GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes.
DiabetesReijonen H, Mallone R, Heninger AK, Laughlin EM, Kochik SA, Falk B, Kwok WW, Greenbaum CJ, Nepom GT
