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Complexity of human immune response profiles for CD4+ T cell epitopes from the diabetes autoantigen GAD65.
AutoimmunityMasewicz SA, Meldrum N, Gersuk V, Gaur L, Hagopian W, Moriarity L, Nepom GT -
Distinct T cell interactions with HLA class II tetramers characterize a spectrum of TCR affinities in the human antigen-specific T cell response.
J ImmunolReichstetter S, Ettinger RA, Liu AW, Gebe JA, Nepom GT, Kwok WW -
GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65.
DiabetesReijonen H, Daniels TL, Lernmark A, Nepom GT -
Beta 57-Asp plays an essential role in the unique SDS stability of HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC allele associated with protection from insulin-dependent diabetes mellitus.
J ImmunolEttinger RA, Liu AW, Nepom GT, Kwok WW -
Increased frequency of HLA class II alleles DRB1*0301 and DQB1*0201 in Lambert-Eaton myasthenic syndrome without associated cancer.
Hum ImmunolParsons KT, Kwok WW, Gaur LK, Nepom GT -
Gene therapy in the treatment of autoimmune diseases.
J Clin InvestTsokos GC, Nepom GT -
HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells.
J ImmunolKwok WW, Liu AW, Novak EJ, Gebe JA, Ettinger RA, Nepom GT, Reymond SN, Koelle DM -
HLA class I and class II profiles of patients presenting with Sydenham's chorea.
J NeurolDonadi EA, Smith AG, Louzada-Júnior P, Voltarelli JC, Nepom GT -
Antigen recognition.
Curr Opin ImmunolSette A, Nepom GT -
Molecular aspects of HLA class II alphabeta heterodimers associated with IDDM susceptibility and protection.
Rev ImmunogenetEttinger RA, Nepom GT -
MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen.
J Clin InvestNovak EJ, Liu AW, Nepom GT, Kwok WW -
Immunogenetic analysis suggests different pathogenesis for obese and lean African-Americans with diabetic ketoacidosis.
Diabetes CareUmpierrez GE, Woo W, Hagopian WA, Isaacs SD, Palmer JP, Gaur LK, Nepom GT, Clark WS, Mixon PS, Kitabchi AE -
Allelic variation in transcription modulates MHC class II expression and function.
Microbes InfectBeaty JS, Sukiennicki TL, Nepom GT -
Peptide binding affinity and pH variation establish functional thresholds for activation of HLA-DQ-restricted T cell recognition.
Hum ImmunolKwok WW, Reijonen H, Falk BA, Koelle DM, Nepom GT -
MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition.
Hum ImmunolReichstetter S, Kwok WW, Kochik S, Koelle DM, Beaty JS, Nepom GT
