-
Inflammatory Pathways in Residual Asthma Exacerbations Among Mepolizumab-Treated Urban Children: A Secondary Analysis of a Randomized Clinical Trial
JAMA PediatrMatthew C Altman, Tomasz Janczyk, Ryan C Murphy, Naresh Doni Jayavelu, Agustin Calatroni, Meyer Kattan , Michelle A Gill, Jeffrey Stokes, Andrew H Liu , Gurjit K Khurana Hershey, Michael Sherenian, Rajesh Kumar, Rachel G Robison, Rebecca S Gruchalla, George T O'Connor, Edward M Zoratti, Stephen J Teach, Susan V Lynch, Kimberly A Dill-McFarland, Patrice M Becker, Alkis Togias, James E Gern, Leonard B Bacharier, William W Busse, Daniel J Jackson, Inner City Asthma Consortium and Childhood Asthma in Urban Settings Network -
Single-cell transcriptomic profiling of eosinophils and airway immune cells in childhood asthma
J Allergy Clin ImmunolNaresh Doni Jayavelu, Andrew H Liu , Courtney Gaberino, Kristy Freeman, Matthew Lawrance, Stephan Pribitzer, Clara Seifert, Cullen Dutmer, Alkis Togias, Patrice M Becker, William W Busse, Christine A Sorkness, Carmen Mikacenic, Kimberly A Dill-McFarland, Daniel J Jackson, Matthew C Altman -
Cockroach immunotherapy modulates dominant T cell responses independent of allergen extract content
J Allergy Clin ImmunolRicardo da Silva Antunes, Aaron Sutherland, Adam Abawi , April Frazier, Anna Pomés, Jill Glesner, Jay E Slater, Samuel T Mindaye, Kate Cho, Grace Zhou, Marie V Ozanne, Agustin Calatroni, Cynthia M Visness, Matthew C Altman, Robert A Wood, George T O'Connor, Jacqueline A Pongracic, Gurjit K Khurana Hershey, Carolyn M Kercsmar, Rebecca S Gruchalla, Michelle Gill, Daniel Searing, Andrew H Liu , Edward Zoratti, Meyer Kattan , Will Sheehan, Leonard B Bacharier, Stephen J Teach, Lisa M Wheatley , Alkis Togias, William W Busse, Daniel J Jackson, Alessandro Sette -
Airway Immune Signatures in Severe and Fatal Infection with COVID-19.
Am J Respir Cell Mol BiolDoni Jayavelu N, Qi JJ, Fourati S, Kheradmand F, Langelier CR, Ehrlich LIR, Diray-Arce J, Hoch A, Kraft M, Becker PM, Altman MC, Montgomery RR -
Early-life wheeze trajectories are associated with distinct asthma transcriptomes later in life
J Allergy Clin ImmunolKieran J Phelan, Krishna M Roskin, Jeffrey W Burkle, Wan-Chi Chang, Lisa J Martin , Jocelyn M Biagini, Latha Satish, David B Haslam, Daniel Spagna, Seth Jenkins, Elsie Parmar, Leonard B Bacharier, Tebeb Gebretsadik, Michelle Gill, Diane R Gold, Daniel J Jackson, Christine C Johnson, Susan V Lynch, Kathryn E McCauley, Chris G McKennan, Rachel Miller, Carole Ober, Dennis R Ownby, Patrick H Ryan, Nathan Schoettler, Sweta Singh, Cynthia M Visness, Matthew C Altman, James E Gern, Gurjit K Khurana Hershey, Environmental Influences on Child Health Outcomes–Children’s Respiratory and Environmental Workgroup -
Reduced Function of the Adaptor SH2B3 Promotes T1D via Altered Cytokine-Regulated, T-Cell-Intrinsic Immune Tolerance.
DiabetesWatson TK, Rosen ABI, Drow T, Medjo JA, MacQuivey MA, Ge Y, Liggitt HD, Grosvenor DA, Dill-McFarland KA, Altman MC, Concannon PJ, Buckner JH, Rawlings DJ, Allenspach EJ -
Dysregulation of airway and systemic interferon responses promotes asthma exacerbations in urban children.
J Allergy Clin ImmunolGaberino CL, Altman MC, Gill MA, Bacharier LB, Gruchalla RS, O'Connor GT, Kumar R, Khurana Hershey GK, Kattan M, Liu AH, Teach SJ, Zoratti EM, Becker PM, Togias A, Visness C, Gern JE, Busse WW, Jackson DJ -
Identification of bronchial epithelial genes associated with type 2 eosinophilic inflammation in asthma.
J Allergy Clin ImmunolEsnault S, Dill-McFarland KA, Altman MC, Rosenkranz MA, Jarjour NN, Busse WW -
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients.
Nat CommunPickering H, Schaenman J, Phan HV, Maguire C, Tsitsiklis A, Rouphael N, Higuita NIA, Atkinson MA, Brakenridge S, Fung M, Messer W, IMPACC Network, Salehi-Rad R, Altman MC, Becker PM, Bosinger SE, Eckalbar W, Hoch A, Doni Jayavelu N, Kim-Schulze S, Jenkins M, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Diray-Arce J, Shaw A, Baden L, Levy O, Reed EF, Langelier CR -
Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping.
bioRxivWang K, Nie Y, Maguire C, Syphurs C, Sheen H, Karoly M, Lapp L, Gygi JP, Jayavelu ND, Patel RK, Hoch A, IMPACC Network, Corry D, Kheradmand F, McComsey GA, Fernandez-Sesma A, Simon V, Metcalf JP, Higuita NIA, Messer WB, Davis MM, Nadeau KC, Kraft M, Bime C, Schaenman J, Erle D, Calfee CS, Atkinson MA, Brackenridge SC, Hafler DA, Shaw A, Rahman A, Hough CL, Geng LN, Ozonoff A, Haddad EK, Reed EF, van Bakel H, Kim-Schultz S, Krammer F, Wilson M, Eckalbar W, Bosinger S, Langelier CR, Sekaly RP, Montgomery RR, Maecker HT, Krumholz H, Melamed E, Steen H, Pulendran B, Augustine AD, Cairns CB, Rouphael N, Becker PM, Fourati S, Shannon CP, Smolen KK, Peters B, Kleinstein SH, Levy O, Altman MC, Iwasaki A, Diray-Arce J, Ehrlich LIR, Guan L -
Oncostatin-M Is Produced by Human Eosinophils and Expression Is Increased in Uncontrolled Severe Asthma.
AllergyEsnault S, Bernau K, Floerke HL, Dendooven A, Delaunay E, Dill-McFarland KA, Altman MC, Busse WW, Rosenkranz MA, Tattersall MC, Johansson MW, Labreuche J, Beury D, Sebda S, Dezoteux F, Segard B, Mortuaire G, Staumont-Sallé D, Stoup T, Chenivesse C, Sandbo N, Jarjour NN, Lefèvre G -
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19.
bioRxivMaguire C, Chen J, Rouphael N, Pickering H, Phan HV, Glascock A, Chu V, Dandekar R, Corry D, Kheradmand F, Baden LR, Selaky R, McComsey GA, Haddad EK, Cairns CB, Pulendran B, Fernandez-Sesma A, Simon V, Metcalf JP, Higuita NIA, Messer WB, David MM, Nadeau KC, Kraft M, Bime C, Schaenman J, Erle D, Calfee CS, Atkinson MA, Brackenridge SC, Ehrlich LIR, Montgomery RR, Shaw AC, Hough CL, Geng LN, Hafler DA, Augustine AD, Becker PM, Peters B, Ozonoff A, Kim-Schulze SH, Krammer F, Bosinger S, Eckalbar W, Altman MC, Wilson M, Guan L, Kleinstein SH, IMPACC Network, Smolen KK, Reed EF, Levy O, Maecker H, Hunt P, Steen H, Diray-Arce J, Langelier CR, Melamed E -
Clinical and Molecular Analysis of Longitudinal Rhinitis Phenotypes in an Urban Birth Cohort.
J Allergy Clin ImmunolRamratnam SK, Johnson M, Visness CM, Calatroni A, Altman MC, Janczyk T, McCauley KE, Schachtschneider C, Fujimura KE, Fadrosh DW, Lynch SV, Bacharier LB, O'Connor GT, Sandel MT, Kattan M, Wood RA, Gergen PJ, Jackson DJ, Togias A, Gern JE, Childhood Asthma in Urban Settings (CAUSE) network -
Home and school pollutant exposure, respiratory outcomes, and influence of historical redlining.
J Allergy Clin ImmunolJung KH, Argenio KL, Jackson DJ, Miller RL, Perzanowski MS, Rundle AG, Bacharier LB, Busse WW, Cohen RT, Visness CM, Gill MA, Gruchalla RS, Hershey GK, Kado RK, Sherenian MG, Liu AH, Makhija MM, Pillai DK, Rivera-Spoljaric K, Gergen PJ, Altman MC, Sandel MT, Sorkness CA, Kattan M, Lovinsky-Desir S -
Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations.
Nat CommunSzczesny B, Boorgula MP, Chavan S, Campbell M, Johnson RK, Kammers K, Thompson EE, Cox MS, Shankar G, Cox C, Morin A, Lorizio W, Daya M, Kelada SNP, Beaty TH, Doumatey AP, Cruz AA, Watson H, Naureckas ET, Giles BL, Arinola GA, Sogaolu O, Falade AG, Hansel NN, Yang IV, Olopade CO, Rotimi CN, Landis RC, Figueiredo CA, Altman MC, Kenny E, Ruczinski I, Liu AH, Ober C, Taub MA, Barnes KC, Mathias RA