Khor Lab


The Khor lab is interested in understanding novel pathways that regulate tolerance and inflammation, with the goal of developing novel precision therapies. A major focus of the lab is understanding the mechanistic basis of immune dysregulation in people with Down syndrome.

This work is revealing new fundamental lessons about the pathoimmunology of aging and autoimmunity in people both with and without Down syndrome. Our work is already pointing to new targets for precision therapies and highlighting novel approaches to identify unifying themes across different diseases.

We take a multidisciplinary and collaborative approach that brings together genetics, chemistry, computational, and clinical collaborators to highlight disease-relevant biology. Work in the lab is grounded on observation in human cohorts, which is then mechanistically interrogated using ex vivo, in vitro and animal model approaches. The Khor lab is a high-mentoring environment where trainees take creative, rigorous, and multidisciplinary approaches to clinically relevant problems.

Bernard Khor
Assistant Member

Bernard Khor, MD, PhD

Associate Member; Principal Investigator, Khor Lab; Associate Medical Director, Bloodworks Northwest; Affiliant Assistant Professor, University of Washington
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Lab Members

Amber Leonard

Amber Leonard, PhD

Post Doctoral Research Associate, Khor Lab; Center for Translational Immunology

Research Projects

Khor Research Project Preview - Immune Aging in DS

Aging and Down syndrome: The immune system and beyond

This study aims to understand how and why immune aging is altered in people with Down syndrome.
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Khor Research Project Preview - Autoimmunity in DS

Dissecting the mechanisms driving autoimmunity in people with Down syndrome

This study aims to understand how and why risk of autoimmunity is increased in people with Down syndrome.
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Khor Research Project Preview - Understanding DYRK1A

Understanding how DYRK1A regulates T cell biology

This study aims to identify the mechanisms engaged by DYRK1A, a novel regulator of Th17 differentiation
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