Benaroya Research Institute (BRI) is on a mission to predict, prevent, reverse and cure immune system diseases. We study the cells and processes within the immune system, how and why immune system diseases start, and how to rebalance the immune system back to health. Our focus spans a wide variety of immune system diseases – including autoimmune diseases, asthma, allergy, cancer and COVID-19 – with the goal of transforming our understanding of how to prevent and treat these conditions.
Collaboration defines our work. We build teams within our institute and with partners around the world to take on some of the most difficult questions in immunology. This approach moves us closer to our vision of a healthy immune system for everyone.
Our Centers of Discovery: A pipeline from lab research to life-changing care
BRI’s research is organized around four Centers of Discovery, allowing us to accelerate advances at every stage of our work. Our centers enable us to make discoveries in the lab and provide a foundation for new and innovative therapies. They also help us to take questions directly from the clinic — such as what makes a therapy work for one person and not another — back to our labs to find meaningful answers.
Our Biorepositories
BRI is home to 11 biorepositories with thousands of blood and tissue samples that have been donated to science, spanning 20 different immune system diseases as well as healthy controls. Access to human samples allows us to closely study diseases in the lab, make new insights, and bring those insights to patient care faster.
Our Core Labs: Building and using the latest tools and technologies
Our Core Labs enable our scientists to build and use some of the most innovative tools in immunology that allow for advanced imaging, data sequencing and exploring the human genome. Each core is led by an expert in their field. Scientists across BRI and from other institutes can partner with these experts to leverage these tools and fuel discoveries in all areas of research.
Our Team: Together we discover
Collaboration is one of BRI’s core values, and our team is our biggest asset. We have built our organization to facilitate teamwork across disease areas, with experts working across fields and with partners around the globe. Shared resources like our Core Labs, Clinical Research Center and biorepositories fuel discoveries across our institute.
Featured Publications
May 2025
Ara h 2105-124-Specific TH2A Cells Drive Peanut Allergy in DRB1*15:01 Individuals: A Detailed Epitope Analysis
Clin Exp Allergy
Rebecca A Gomez, Jue Hou, Vivian H Gersuk, I-Ting Chow, Mary L Farrington, David Robinson, William W Kwok
Apr 2025
Type 1 Diabetes TrialNet: Leading the Charge in Disease Prediction, Prevention, and Immunotherapeutic Mechanistic Understanding
Laura M Jacobsen, Jamie L Felton, Brandon M Nathan, Cate Speake, Jeffrey Krischer, Kevan C Herold
Apr 2025
A ventilated perfused lung model platform to dissect the response of the lungs to viral infection
Trends in Biotechnology
I Deniz Derman, Mecit Altan Alioglu, Joseph Christakiran Moses, Zissis C Chroneos , Yasar Ozer Yilmaz, Dishary Banerjee, Jonathan Koff, Syed Hasan Askari Rizvi, Danielle Nicole Klunk, Nazmiye Celik, Sirisha Pochareddy, Todd M Umstead, Ilayda Namli , Sarah E Holton, Carmen Mikacenic, Jessica L Thompson, Diana Cadena Castaneda, Danielle Reifsnyder Hickey, Momoka Nagamine, Prajakta Warang, Michael Schotsaert, Phylip Chen, Mark E Peeples, Karolina Palucka, Ibrahim T Ozbolat
Apr 2025
TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation
EMBO Rep
Thomas E Schultz, Carmen D Mathmann, Leslie C Domínguez Cadena, Timothy W Muusse, Hyoyoung Kim, James W Wells, Glen C Ulett, Jessica A Hamerman, Andrew J Brooks, Bostjan Kobe, Matthew J Sweet, Katryn J Stacey, Antje Blumenthal
Apr 2025
Rheumatoid arthritis - the role of T cells in this complex systemic autoimmune disease
Curr Opin Immunol
Christina S Savvides, Eddie A James, Jane H Buckner
