S. Alice Long, PhD

Research Associate Member; Manager, Human Immunophenotyping Core Lab
Office Phone: 
(206) 287-1034

Background Information

Dr. Alice Long received her BS degree in Biology from Macalester College in St. Paul, MN, and earned her PhD in Immunology from Emory University in Atlanta, GA. She then pursued post-doctoral studies at the University of California at Davis studying the etiology and pathogenesis of primary biliary cirrhosis, an autoimmune disease of the liver. She next joined a Seattle-based biotechnology company, Xcyte Therapies, where she helped develop adoptive T-cell therapies for multiple diseases. In 2005, she joined Benaroya Research Institute (BRI) as a staff scientist in the laboratory of Dr. Buckner where she applied her T-cell therapy experience to adoptive Treg therapy in T1D while studying the etiology and pathogenesis of T1D. In 2011, she joined the faculty at BRI and is currently a Research Associate Member and Manager of the Human Immunophenotyping Core.

Area of Research

Dr. Long’s lab is a translational immunology lab focused on discovering how the adaptive immune system is dysregulated in human autoimmunity. Specifically, her current research includes three inter-related projects in the setting of T1D.

  1. Causes and consequences of reduced response to IL-2 in CD4 T cells of T1D subjects,
  2. cellular definition, function and stability of CD8 T cell exhaustion associated with beneficial response to therapy and
  3. identification of biomarkers of progressors vs non-progressors.

Long Laboratory

Human Immunophenotyping Core

Translational Research Program