Jessica A. Hamerman, PhD
Jessica Hamerman received her BS in Biological Sciences from Stanford University and her PhD in Immunology from the University of Washington. She then pursued postdoctoral studies at the University of California San Francisco before joining the Benaroya Research Institute Immunology Program in 2006. Dr. Hamerman is also an Affiliate Associate Professor in the Department of Immunology at the University of Washington School of Medicine.
Area of Research
Projects in Dr. Hamerman’s laboratory are focused on understanding the regulation of the inflammatory response of macrophages and dendritic cells, two types of white blood cells involved in the early defense against infection. Although this inflammatory response is beneficial to the host for pathogen clearance, it can be detrimental if unchecked. This can be seen in septic shock as well as in autoimmune disorders such as rheumatoid arthritis. Dr. Hamerman’s studies will not only help elucidate how the inflammatory response is regulated during infection, but will potentially give insights in how to manipulate the innate immune system to achieve more efficient elimination of pathogens and to regulate the inflammatory response during disease.
Sun X, Wiedeman A, Agrawal N, Teal TH, Tanaka L, Hudkins KL, Alpers CE, Bolland S, Buechler MB, Hamerman JA, Ledbetter JA, Liggitt D, and Elkon KB (2013) Increased RNase Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice. Journal of Immunology. 2013 Mar 15;190(6):2536-43. PMID: 23382559.
Yee NK, Hamerman JA (2013). β(2) integrins inhibit TLR responses by regulating NF-κB pathway and p38 MAPK activation. European Journal of Immunology. 2013 Mar;43(3):779-92 PMID: 23310953.
Buechler MB, Teal TH, Elkon KB, Hamerman JA (2013) Cutting Edge: Type I IFN Drives Emergency Myelopoiesis and Peripheral Myeloid Expansion during Chronic TLR7 Signaling. Journal of Immunology. 2013 Feb1;190(3):886-91 PMID: 23303674.
Jhingran A, Mar KB, Kumasaka DK, Knoblaugh SE, Ngo LY, Segal BH, Iwakura Y, Lowell CA, Hamerman JA, Lin X, Hohl TM (2012) Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Reports 2012 Dec 27;2(6):1762-73.
Ni M, MacFarlane AW, Toft M, Lowell CA, Campbell KS, Hamerman JA (2012) BCAP negatively regulates Toll-like receptor signaling through activation of PI3-Kinase. Proceedings of the National Academy of Sciences USA 2012 Jan 3;109(1):267-72. PMCID: PMC3252908
Ito H and Hamerman JA (2012) TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells. European Journal of Immunology 2012 Jan;42(1)176-85. PMCID: PMC3444819
Hamerman JA, Ni M, Killebrew JR, Chu C-L, Lowell CA (2009) The expanding roles of ITAM adapters FcRγ and DAP12 in myeloid cells. Immunological Reviews Nov;232(1):42-58. PMCID: PMC3248395
N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE (2009) TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. Journal of Cell Biology, Jan 26;184(2):215-23.
Chu CL, Yu YL, Shen KY, Lowell CA, Lanier LL, Hamerman JA (2008) Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRγ, European Journal of Immunology, 38 (1), 166-73. PMCID: PMC2587008
Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL (2006) Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12., Journal of Immunology, 177 (4), 2051-5.
Hamerman JA, Tchao NK, Lowell CA, Lanier LL (2005) Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12., Nature Immunology, 6 (6), 579-86.