Daniel J. Campbell, PhD
Dr. Campbell graduated with honors from the University of Michigan in 1993, and received his PhD in Molecular and Cell Biology from the University of California, Berkeley in 1998. Following a postdoctoral fellowship at Stanford University, Dr. Campbell joined the faculty of the Benaroya Research Institute as an Assistant Member in 2003. He is currently Director of the Center for Fundamental Immunology and a Member at BRI. He is also an Affiliate Assistant Professor in the Department of Immunology at the University of Washington School of Medicine.
Area of Research
Research in Dr. Campbell’s laboratory is focused on understanding the regulatory mechanisms that modulate immune responses during autoimmunity and infection. In particular, we are studying how a population of leukocytes called regulatory T cells functions to restrain immune responses, and how these cells can have beneficial effects in preventing autoimmunity, but also can promote chronic infection with pathogens such as Mycobacterium tuberculosis.
Klicznik MM, Morawski PA, Höllbacher B, Varkhande SR, Motley S, Kuri-Cervantes L, Goodwin E, Rosenblum MD, Long SA, Brachtl G, Duhen T, Betts MR, Campbell DJ, Gratz IK. (2019) Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy subjects. Sci. Immunol. 2019 4, eaav8995.
Sullivan JM, Höllbacher B, Campbell DJ. Cutting Edge: Dynamic Expression of Id3 Defines the Stepwise Differentiation of Tissue-Resident Regulatory T Cells. J Immunol. 2019 Jan 1;202(1):31-36. doi: 10.4049/jimmunol.1800917. PMID: 30518568 | PMC6311998
Singh MD, Ni M, Sullivan JM, Hamerman JA, Campbell DJ. B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation. J Exp Med. 2018 Sep 3;215(9):2429-2443. doi: 10.1084/jem.20171820. PMID: 30093532 | PMC6122975
Newton RH, Shrestha S, Sullivan JM, Yates KB, Compeer EB, Ron-Harel N, Blazar BR, Bensinger SJ, Haining WN, Dustin ML, Campbell DJ, Chi H, Turka LA. Maintenance of CD4 T cell fitness through regulation of Foxo1. Nat Immunol. 2018 Aug;19(8):838-848. doi: 10.1038/s41590-018-0157-4. PMID: 29988091 | PMC6289177
Stolley JM, Campbell DJ. A 33D1+ Dendritic Cell/Autoreactive CD4+ T Cell Circuit Maintains IL-2-Dependent Regulatory T Cells in the Spleen. J Immunol. 2016 Oct 1;197(7):2635-45. doi: 10.4049/jimmunol.1600974. PMID: 27566821 | PMC5026945
Buechler MB, Gessay GM, Srivastava S, Campbell DJ, Hamerman JA. Hematopoietic and nonhematopoietic cells promote Type I interferon- and TLR7-dependent monocytosis during low-dose LCMV infection. Eur J Immunol. 2015 Nov;45(11):3064-72. doi: 10.1002/eji.201445331. PMID: 26289159 | PMC4675142
Srivastava S, Koch MA, Pepper M, Campbell DJ. Type I interferons directly inhibit regulatory T cells to allow optimal anti-viral T cell responses during acute infection. J Exp Med. 2014 May 5;211(5):961-74. doi: 10.1084/jem.20131556. PMID: 24711580 | PMC4010906
Gratz IK, Campbell DJ. Organ-specific and memory treg cells: specificity, development, function, and maintenance. Front Immunol. 2014 Jul 15;5:333. doi: 10.3389/fimmu.2014.00333. eCollection 2014. PMID: 25076948 | PMC4098124
Smigiel KS, Richards E, Srivastava S, Thomas KR, Dudda JC, Klonowski KD, Campbell DJ. CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets. J Exp Med. 2014 Jan 13;211(1):121-36. doi: 10.1084/jem.20131142. PMID: 24378538 | PMC3892972
Duhen T, Campbell DJ. IL-1β promotes the differentiation of polyfunctional human CCR6+CXCR3+ Th1/17 cells that are specific for pathogenic and commensal microbes. J Immunol. 2014 Jul 1;193(1):120-9. doi: 10.4049/jimmunol.1302734. PMID: 24890729 | PMC4068296
Smigiel KS, Srivastava S, Stolley JM, Campbell DJ. Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation. Immunol Rev. 2014 May;259(1):40-59. doi: 10.1111/imr.12170. PMID: 24712458 | PMC4083836
Duhen T, Duhen R, Lanzavecchia A, Sallusto F, Campbell DJ. Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells. Blood. 2012 May 10;119(19):4430-40. doi: 10.1182/blood-2011-11-392324. PMID: 22438251 | PMC3362361
Koch MA, Thomas KR, Perdue NR, Smigiel KS, Srivastava S, Campbell DJ. T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2. Immunity. 2012 Sep 21;37(3):501-10. doi: 10.1016/j.immuni.2012.05.031. PMID: 22960221 | PMC3501343
Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol. 2009 Jun;10(6):595-602. doi: 10.1038/ni.1731. PMID: 19412181 | PMC2712126