The Campbell laboratory is interested in understanding the basis for T cell activation, function and tolerance. We use both animal models and human samples to identify functionally relevant populations of effector and regulatory T cells, define the factors that promote their development and maintenance and delineate their roles in healthy immune responses and in immune-mediated diseases.
We are also work to develop and characterize new methods to promote regulatory T cell activity to treat autoimmune disease.
The lab is also studying how T cells interact with and reprogram the responses of structural cells in the skin to regulate normal tissue function, and understanding how this changes during cutaneous inflammatory diseases. We use an array of innovative techniques in this work, including transcriptional and epigenetic profiling of cells isolated from primary human skin samples, tissue explant cultures and organotypic skin culture models.
Daniel J. Campbell, PhD
Campbell Lab Members
Manreet Bhuller
Mitch Fahning
Braxton Jamison, PhD
Samuel Klebanoff
Ayako Takamori, PhD
Lauren Ziegler
Research Projects
Restoring immune tolerance via regulatory T cell-targeted IL-2 mutein therapy
Boosting regulatory T cell activity with targeted versions of IL-2 to arrest ongoing autoimmunity and restore immune tolerance.
T cell-structural cell interaction in the skin
The structural cells of the skin have an important role in cutaneous immunity. This project examines how they are reprogrammed by skin-resident T cells, and how this in turn regulates inflammatory and autoimmune diseases at this site.
Featured Publications
Divergent effects of a Treg-selective IL-2 mutein on influenza-specific T cell responses
J Immunol
Loss of the actin remodeling protein Flightless-1 impairs CD8 and regulatory T cell function
bioRxiv
T cells promote distinct transcriptional programs of cutaneous inflammatory disease in keratinocytes and dermal fibroblasts
J Invest Dermatol
Pharmacotherapeutic strategies to promote regulatory T cell function in autoimmunity.
Curr Opin Immunol
An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy.
Cell Rep
Revolutionary Microscope to Fuel Immunology Breakthroughs
What if we could take a blood sample from a person with rheumatoid arthritis, zero in on the immune cells that cause the disease, and watch what they’re doing in real-time video?
Exploring New Frontiers of Skin Immunology
Immune cells perform different functions in different parts of the body. Some fight off infections in the skin. Others protect the lungs from pollutants. But how do these cells learn to do the right job in the right place? And why does that process sometimes go wrong?
Driven To Teach: From Lab to Lecture Hall
Did you know that BRI researchers aren’t just researchers? They’re teachers, too. In fact, 12 BRI researchers serve on the University of Washington (UW) faculty, two of which also teach at the Chiba University School of Medicine in Japan.
News
Benaroya Research Institute Awarded More Than $14 Million Across 11 Grants To Help Predict, Prevent, Reverse and Cure Immune System Diseases
Read More
Benaroya Research Institute Receives $9 Million in Funding, With a Focus on Down Syndrome Research
Read More
