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May 2019
Cutting Edge: BCAP Promotes Lupus-like Disease and TLR-Mediated Type I IFN Induction in Plasmacytoid Dendritic Cells.
J ImmunolChu T, Ni M, Chen C, Akilesh S, Hamerman JA -
Jan 2019
Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes.
ScienceAkilesh HM, Buechler MB, Duggan JM, Hahn WO, Matta B, Sun X, Gessay G, Whalen E, Mason M, Presnell SR, Elkon KB, Lacy-Hulbert A, Barnes BJ, Pepper M, Hamerman JA -
Sep 2018
B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation.
J Exp MedSingh MD, Ni M, Sullivan JM, Hamerman JA, Campbell DJ -
May 2018
A Novel Strategy to Prevent Advanced Atherosclerosis and Lower Blood Glucose in a Mouse Model of Metabolic Syndrome.
DiabetesKanter JE, Kramer F, Barnhart S, Duggan JM, Shimizu-Albergine M, Kothari V, Chait A, Bouman SD, Hamerman JA, Hansen BF, Olsen GS, Bornfeldt KE -
Jan 2018
cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses.
JCI InsightHahn WO, Butler NS, Lindner SE, Akilesh HM, Sather DN, Kappe SH, Hamerman JA, Gale M Jr, Liles WC, Pepper M -
Mar 2017
BCAP inhibits proliferation and differentiation of myeloid progenitors in the steady state and during demand situations.
BloodDuggan JM, Buechler MB, Olson RM, Hohl TM, Hamerman JA -
Oct 2016
Cutting Edge: Direct Sensing of TLR7 Ligands and Type I IFN by the Common Myeloid Progenitor Promotes mTOR/PI3K-Dependent Emergency Myelopoiesis.
J ImmunolBuechler MB, Akilesh HM, Hamerman JA -
Jan 2016
Negative regulation of TLR signaling in myeloid cells--implications for autoimmune diseases.
Immunol RevHamerman JA, Pottle J, Ni M, He Y, Zhang ZY, Buckner JH -
Nov 2015
Hematopoietic and nonhematopoietic cells promote Type I interferon- and TLR7-dependent monocytosis during low-dose LCMV infection.
Eur J ImmunolBuechler MB, Gessay GM, Srivastava S, Campbell DJ, Hamerman JA -
Jul 2015
The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages.
J ImmunolTampella G, Kerns HM, Niu D, Singh S, Khim S, Bosch KA, Garrett ME, Moguche A, Evans E, Browning B, Jahan TA, Nacht M, Wolf-Yadlin A, Plebani A, Hamerman JA, Rawlings DJ, James RG -
Nov 2013
Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells.
J Exp MedGiltiay NV, Chappell CP, Sun X, Kolhatkar N, Teal TH, Wiedeman AE, Kim J, Tanaka L, Buechler MB, Hamerman JA, Imanishi-Kari T, Clark EA, Elkon KB -
Jul 2013
TLR-2/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury.
PLoS OneCampanholle G, Mittelsteadt K, Nakagawa S, Kobayashi A, Lin SL, Gharib SA, Heinecke JW, Hamerman JA, Altemeier WA, Duffield JS -
Mar 2013
Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice.
J ImmunolSun X, Wiedeman A, Agrawal N, Teal TH, Tanaka L, Hudkins KL, Alpers CE, Bolland S, Buechler MB, Hamerman JA, Ledbetter JA, Liggitt D, Elkon KB -
Mar 2013
β(2) integrins inhibit TLR responses by regulating NF-κB pathway and p38 MAPK activation.
Eur J ImmunolYee NK, Hamerman JA -
Feb 2013
Cutting edge: Type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signaling.
J ImmunolBuechler MB, Teal TH, Elkon KB, Hamerman JA