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Proteomic Differences in Colonic Epithelial Cells in Ulcerative Colitis Have an Epigenetic Basis.
Gastro Hep AdvJelinsky S, Lee I, Monetti M, Breitkopf S, Martz F, Kongala R, Culver J, Vo V, Xue L, Gieseck R 3rd, Dickinson C, Kasaian M, Lord JD -
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
Nat CommunMartinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Zihsler S, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL, Kuipers HF -
Colonic mucosal associated invariant T cells in Crohn's disease have a diverse and non-public T cell receptor beta chain repertoire.
PLoS OneKonecny AJ, Shows DM, Lord JD -
Janus kinase inhibitors differentially inhibit specific cytokine signals in the mesenteric lymph node cells of IBD patients.
J Crohns ColitisHindmarch DC, Malashanka S, Shows DM, Clarke AS, Lord JD -
Vedolizumab Efficacy Is Associated With Decreased Intracolonic Dendritic Cells, Not Memory T Cells.
Inflamm Bowel DisBoden EK, Kongala R, Hindmarch DC, Shows DM, Juarez JG, Lord JD -
T Cell Repertoire Homogeneity and Blood-Gut Overlap in Patients with Inflammatory Bowel Disease.
Cell Mol Gastroenterol HepatolWilliams KG, Kongala R, Shows DM, Konecny AJ, Hindmarch DC, Clarke AS, Lord JD -
FOXP3(+) regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues.
bioRxivMartinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL, Kuipers HF -
Usefulness of Fluoroscopy for Endoscopic Balloon Dilation of Crohn's Disease-Related Strictures.
Dig Dis SciLee HS, Chiorean MV, Boden E, Lord JD, Irani S , Kozarek RA, Larsen M , Ross A -
MAdCAM-1 Costimulates T Cells through Integrin α(4)β(7) to Cause Gene Expression Events Resembling Costimulation through CD28.
ImmunohorizonsDeBerg HA, Konecny AJ, Shows DM, Lord JD -
PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection.
J Exp MedOyesola OO, Shanahan MT, Kanke M, Mooney BM, Webb LM, Smita S, Matheson MK, Campioli P, Pham D, Früh SP, McGinty JW, Churchill MJ, Cahoon JL, Sundaravaradan P, Flitter BA, Mouli K, Nadjsombati MS, Kamynina E, Peng SA, Cubitt RL, Gronert K, Lord JD, Rauch I, von Moltke J, Sethupathy P, Tait Wojno ED -
Escherichiacoli-Specific CD4+ T Cells Have Public T-Cell Receptors and Low Interleukin 10 Production in Crohn's Disease.
Cell Mol Gastroenterol HepatolUchida AM, Boden EK, James EA, Shows DM, Konecny AJ, Lord JD -
High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue.
Mucosal ImmunolKonnikova L, Boschetti G, Rahman A, Mitsialis V, Lord J, Richmond C, Tomov VT, Gordon W, Jelinsky S, Canavan J, Liss A, Wall S, Field M, Zhou F, Goldsmith JD, Bewtra M, Breault DT, Merad M, Snapper SB, Lord JD -
Identification of Candidate Biomarkers Associated with Response to Vedolizumab in Inflammatory Bowel Disease.
Dig Dis SciBoden EK, Shows DM, Chiorean MV, Lord JD -
Circulating integrin alpha4/beta7+ lymphocytes targeted by vedolizumab have a pro-inflammatory phenotype.
Clin ImmunolLord JD, Long SA, Shows DM, Thorpe J, Schwedhelm K, Chen J, Kita M, Buckner JH -
CD4 T Cells in IBD: Crossing the Line?
Dig Dis SciBoden EK, Lord JD
