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Differentiation of cardiomyocytes from human embryonic stem cells is accompanied by changes in the extracellular matrix production of versican and hyaluronan.
J Cell BiochemChan CK, Rolle MW, Potter-Perigo S, Braun KR, Van Biber BP, Laflamme MA, Murry CE, Wight TN -
PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL.
EndocrinologyGetachew R, Ballinger ML, Burch ML, Reid JJ, Khachigian LM, Wight TN, Little PJ, Osman N -
Polyinosine-polycytidylic acid stimulates versican accumulation in the extracellular matrix promoting monocyte adhesion.
Am J Respir Cell Mol BiolPotter-Perigo S, Johnson PY, Evanko SP, Chan CK, Braun KR, Wilkinson TS, Altman LC, Wight TN -
Proteoglycans: key regulators of pulmonary inflammation and the innate immune response to lung infection.
Anat Rec (Hoboken)Gill S, Wight TN, Frevert CW -
Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse.
Cell Mol ImmunolBollyky PL, Evanko SP, Wu RP, Potter-Perigo S, Long SA, Kinsella B, Reijonen H, Guebtner K, Teng B, Chan CK, Braun KR, Gebe JA, Nepom GT, Wight TN -
Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation.
J Histochem CytochemShukla S, Nair R, Rolle MW, Braun KR, Chan CK, Johnson PY, Wight TN, McDevitt TC -
Platelet-derived growth factor differentially regulates the expression and post-translational modification of versican by arterial smooth muscle cells through distinct protein kinase C and extracellular signal-regulated kinase pathways.
J Biol ChemCardoso LE, Little PJ, Ballinger ML, Chan CK, Braun KR, Potter-Perigo S, Bornfeldt KE, Kinsella MG, Wight TN -
Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs.
J ImmunolTanino Y, Coombe DR, Gill SE, Kett WC, Kajikawa O, Proudfoot AE, Wells TN, Parks WC, Wight TN, Martin TR, Frevert CW -
Expression of versican isoform V3 in the absence of ascorbate improves elastogenesis in engineered vascular constructs.
Tissue Eng Part AKeire PA, L'Heureux N, Vernon RB, Merrilees MJ, Starcher B, Okon E, Dusserre N, McAllister TN, Wight TN -
Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation.
DiabetesYeop Han C, Kargi AY, Omer M, Chan CK, Wabitsch M, O'Brien KD, Wight TN, Chait A -
Organization of hyaluronan and versican in the extracellular matrix of human fibroblasts treated with the viral mimetic poly I:C.
J Histochem CytochemEvanko SP, Potter-Perigo S, Johnson PY, Wight TN -
Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells.
J Leukoc BiolBollyky PL, Falk BA, Wu RP, Buckner JH, Wight TN, Nepom GT -
CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta.
J ImmunolBollyky PL, Falk BA, Long SA, Preisinger A, Braun KR, Wu RP, Evanko SP, Buckner JH, Wight TN, Nepom GT -
Cutaneous chronic graft-versus-host disease does not have the abnormal endothelial phenotype or vascular rarefaction characteristic of systemic sclerosis.
PLoS OneFleming JN, Shulman HM, Nash RA, Johnson PY, Wight TN, Gown A, Schwartz SM -
Extracellular matrix molecules: potential targets in pharmacotherapy.
Pharmacol RevJärveläinen H, Sainio A, Koulu M, Wight TN, Penttinen R
