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T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes.
DiabetologiaGuyer P, Seminova K, Lugar M, Manganaro A, Velarde de la Cruz EE, Hartley R, Smithmyer ME, Speake C, Bonifacio E, Kent SC, James EA -
Rheumatoid arthritis - the role of T cells in this complex systemic autoimmune disease.
Curr Opin ImmunolSavvides CS, James EA, Buckner JH -
Novel T-Cell Reactivities to Hybrid Insulin Peptides in Islet Autoantibody-Positive At-Risk Individuals.
DiabetesHohenstein AC, Gallegos JB, Dang M, Groegler J, Broncucia H, Tensun FA, Waugh K, Dong F, James EA, Speake C, Steck AK, Rewers MJ, Gottlieb PA, Haskins K, Delong T, Baker RL -
Antigen-specific T-cell frequency and phenotype mirrors disease activity in DRB1*04:04+ rheumatoid arthritis patients.
Clin Exp ImmunolRims C, Uchtenhagen H, Brooks K, Ng B, Posso SE, Carlin J, Kwok WW, Buckner JH, James EA -
Identification of a novel PDC-E2 epitope in primary biliary cholangitis: Application for engineered Treg therapy.
J AutoimmunTewari R, Yang SJ, McClain ED, Hu A, Mortensen E, DeSchmidt A, Chen J, Kancharla A, Singh AK, James EA, Burman BE, Siddique A, Rawlings DJ, Patel C, Cerosaletti K, Buckner JH -
Distinct mucosal endotypes as initiators and drivers of rheumatoid arthritis.
Nat Rev RheumatolHolers VM, Demoruelle KM, Buckner JH, James EA, Firestein GS, Robinson WH, Steere AC, Zhang F, Norris JM, Kuhn KA, Deane KD -
The insulin secretory granule is a hotspot for autoantigen formation in type 1 diabetes.
DiabetologiaGroegler J, Callebaut A, James EA, Delong T -
Investigating Associations between HLA-DR Genotype, H. pylori Infection, and Anti-CagA IgA Seropositivity in a Turkish Gastritis Cohort.
Genes (Basel)Karataş L, Tatar Z, James EA, Colakogullari M -
CD4+ T cells from individuals with type 1 diabetes respond to a novel class of deamidated peptides formed in pancreatic islets.
DiabetesCallebaut A, Guyer P, Derua R, Buitinga M, Manganaro A, Yi X, Sodré FMC, Vig S, Suleiman M, Marchetti P, Eizirik DL, Kent SC, Mathieu C, James EA, Overbergh L -
An Insulin-Chromogranin A Hybrid Peptide activates DR11 restricted T cells in human type 1 diabetes.
DiabetesCallebaut A, Guyer P, Baker RL, Gallegos JB, Hohenstein AC, Gottlieb PA, Mathieu C, Overbergh L, Haskins K, James EA -
Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis.
Nat CommunJames EA, Holers VM, Iyer R, Prideaux EB, Rao NL, Rims C, Muir VS, Posso SE, Bloom MS, Zia A, Elliott SE, Adamska JZ, Ai R, Brewer RC, Seifert JA, Moss L, Barzideh S, Demoruelle MK, Striebich CC, Okamoto Y, Sainbayar E, Crook AA, Peterson RA, Vanderlinden LA, Wang W, Boyle DL, Robinson WH, Buckner JH, Firestein GS, Deane KD -
The Beta Cell-Immune Cell Interface in Type 1 Diabetes (T1D).
Mol MetabJames EA, Joglekar AV, Linnemann AK, Russ HA, Kent SC -
Editorial: Processing, presentation, and recognition of T cell determinants: From molecular insights to clinical applications.
Cell ImmunolJames EA -
Technical Validation and Utility of an HLA Class II Tetramer Assay for Type 1 Diabetes: A Multicenter Study.
J Clin Endocrinol MetabEttinger RA, Buitinga M, Vandamme C, Afonso G, Gomez R, Arribas-Layton D, Bissenova S, Speake C, Reijonen H, Kinnunen T, Overbergh L, Mallone R, Kwok WW, James EA -
Autoimmune susceptible HLA class II motifs facilitate the presentation of modified neoepitopes to potentially autoreactive T cells.
Cell ImmunolMoustakas AK, Nguyen H, James EA, Papadopoulos GK
