T Cell Exhaustion in New-Onset Type 1 Diabetes Treatment
Study results suggesting that T cell exhaustion markers may be correlated with treatment response in type 1 diabetes (T1D) patients from the Immune Tolerance Network’s AbATE study were published today in Science Immunology. This research, led by Alice Long, PhD, and Peter Linsley, PhD, at Benaroya Research Institute, used integrated systems biology and flow cytometry approaches to investigate pathways associated with C-peptide stabilization in responders to anti-CD3 treatment. The authors determined that a population of CD8 T cells that resemble exhausted T cells is associated with the best treatment outcome, suggesting T cell exhaustion as a potential target for therapy in T1D.
Additional information about AbATE and the results reported in today's publication can be found at immunetolerance.org.