Benaroya Research Institute (BRI) is a world leader in human immune system research. BRI works to advance the science that will predict, prevent, reverse and cure immune system diseases like allergies, asthma, cancer, COVID-19 and autoimmune diseases. BRI accelerates discovery through laboratory breakthroughs in immunology that are then translated to clinical therapies. We believe that a breakthrough in one immune system disease can lead to progress against them all, and work tirelessly toward our vision of a healthy immune system for everyone. BRI is a world-renowned independent nonprofit research institute affiliated with Virginia Mason Franciscan Health and based in Seattle.
New Study from Benaroya Research Institute Identifies Mechanisms for How Two Air Pollutants Exacerbate Asthma in Urban Children
Focuses on children living in low-income urban neighborhoods
Researchers at the Benaroya Research Institute (BRI) and colleagues have published findings today in The Lancet Planetary Health concluding that in the absence of viral infection, elevated air quality index values are associated with asthma exacerbations and lowered lung function in children living in low-income urban neighborhoods.
"Until now, the mechanism for how air pollution exacerbates asthma has been poorly understood," said Matt Altman, MD, MPhil, BRI principal investigator and lead author on the manuscript. "Our findings identify associations between specific air pollutant exposures and airway inflammatory patterns that are present in non-viral asthma exacerbations, contributing to asthma disparities in children living in urban settings."
Through BRI’s Center for Systems Immunology, the research team had access to a state-of-the-art tool called airway transcriptome network analysis. Dr. Altman and other researchers performed a retrospective analysis of data including 208 children aged 6-17 years old with exacerbation-prone asthma in nine cities across the United States. The findings were then validated in another cohort of 419 participants aged 6-20 years with persistent allergic asthma living in urban settings across four U.S. cities. The study found that particulate matter less than 2.5 µm was linked to multiple epithelial inflammatory responses and ozone exposure was linked to type-2 inflammatory responses and reduced lung function.
"Our results support further investigation into potential mechanistic pathways to inform asthma prevention and management," said Dr. Altman.
Dr. Altman conducts asthma research at Benaroya Research Institute and treats asthma patients at UW Medicine. He is a lead mechanistic researcher for Childhood Asthma in Urban Settings (CAUSE), a clinical research network that produced this study. CAUSE and the study are funded by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.