Cardiology Clinical Research

Clinical Trials

Cardiology

Benaroya Research Institute and Virginia Mason Medical Center conduct clinical trials to discover new treatments and approaches to cardiovascular disease. Research studies are conducted for a variety of heart diseases, including heart valve disease, coronary artery disease, hypertrophic cardiomyopathy and atrial fibrillation.

Clinical Research Studies in Cardiology

We have ongoing clinical research studies in multiple areas of cardiovascular disease. Studies labeled as “Enrolling” are actively accepting new participants, while studies labeled as “Closed to Enrollment” are still active but no longer seeking new participants.

Please email Cardiology Clinical Research or call (206) 287-6260 for more information.

Mavacamten Real World Evidence Collaboration in HCM

Principal Investigator: Mariko Harper, MD
Status: Enrolling

A Follow-Up, Open-Label, Research Evaluation of Sustained Treatment with Aficamten (CK3773274) in Hypertrophic Cardiomyopathy (HCM)

Learn more at Clinicaltrials.gov

Principal Investigator: Mariko Harper, MD
Status: Enrolling

EASi-HF – A Phase III double-blind, randomised, parallel-group superiority trial to evaluate efficacy and safety of the combined use of oral BI 690517 and empagliflozin compared with placebo and empagliflozin in participants with symptomatic heart failure

Learn more at Clinicaltrials.gov

Principal Investigator: Sara Weiss, MD
Status: Enrolling

An Open Label Study to Evaluate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Effects of EDG-7500 in Adults with Obstructive Hypertrophic Cardiomyopathy

Learn more at Clinicaltrials.gov

Principal Investigator: Mariko Harper, MD
Status: Enrolling

HERMES: Effects of ziltivekimab versus placebo on morbidity and mortality in patients with heart failure with mildly reduced or preserved ejection fraction and systemic inflammation

Learn more at Clinicaltrials.gov

Principal Investigator: Sara Weiss, MD
Status: Enrolling

Percutaneous or Surgical Mitral Valve REpair in PAtients with Primary Mitral Regurgitation whose mitral valve has been determined to be suitable for correction by MV repair surgery.

Learn more at Clinicaltrials.gov

Principal Investigator: Ming Zhang, MD
Status: Enrolling

A Phase 3, Multi-Center, Randomized, Double-Blind Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults with Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy

Learn more at Clinicaltrials.gov

Principal Investigator: Mariko Harper, MD
Status: Closed to Enrollment

Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial (CLASP II TR)A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter tricuspid valve repair with the Edwards PASCA

A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter tricuspid valve repair with the Edwards PASCAL Transcatheter Valve Repair System and optimal medical therapy (OMT) compared to OMT alone in patients with tricuspid regurgitation.

Learn more at Clinicaltrials.gov

Principal Investigator: Ming Zhang, MD
Status: Closed to Enrollment

Deliver Insights in Hypertrophic Cardiomyopathy and Observational Outcomes in Real World (DISCOVER-HCM): United States Prospective Registry Study

Learn more at Clinicaltrials.gov

Principal Investigator: Mariko Harper, MD
Status: Closed to Enrollment

A randomized, double-blind, placebo-controlled, multicenter trial, assessing the impact of inclisiran on major adverse cardiovascular events in participants with established cardiovascular disease (Victorion-2 PREVENT)

Learn more at Clinicaltrials.gov

Principal Investigator: Drew Baldwin, MD
Status: Closed to Enrollment

Irrigated Radio Frequency Ablation to Terminate Non-Paroxysmal Atrial Fibrillation (Terminate AF Study)

Learn more at Clinicaltrials.gov

Principal Investigator: Robert Moraca, MD
Status: Closed to Enrollment