Uma Malhotra, MD
Background Information
Dr. Malhotra received her MD from the All India Institute of Medical Sciences, the premier institution for medical training and research in India. She then pursued a postdoctoral fellowship in T cell immunology at Benaroya Research Institute (1988-91), following which she completed her internship in Internal Medicine at Oregon Health Sciences University and residency at the California Pacific Medical Center in San Francisco (1991-94). She returned to Seattle for a fellowship in Infectious Diseases at the University of Washington (UW) (1995-98) and then assumed a faculty position at the UW/Fred Hutch until her move to Virginia Mason (VM) in 2008. She has been a Member in the Section of Infectious Diseases at VM since 2008, active in both the clinical and research arenas. She also remains faculty at the UW, serving as Clinical Professor in the Department of Medicine. In addition, she is Director of the Transplant Infectious Diseases program at VM. Her specific clinical interests include the care of immunocompromised patients.
Area of Research
Through her research at the Fred Hutch she helped clarify barriers to the generation and maintenance of effective CD4+ T cell function in HIV-1 infection. She played a lead role in developing a UW International AIDS Research and Training Program (IARTP) site in New Delhi with independent and sustainable research capacities for the prevention and control of HIV. After moving to VM she continued studies of T-helper responses in collaboration with researchers at the BRI, shifting her focus from HIV to Influenza and Flavivirus infections. She now serves as the Clinical PI for the Infectious Diseases and Vaccine Registry at BRI. During the COVID pandemic she served as PI, leading clinical trials at VM for management of COVID-19. She also played a key role in developing and supporting a COVID translational research program at the institution.
Featured Publications
Johansson AM, Malhotra U, Kim YG, Gomez R, Krist MP, Wald A, Koelle DM, Kwok WW. Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals. PLoS Pathog. 2021 Dec 29;17(12):e1010203. doi: 10.1371/journal.ppat.1010203. PMID: 34965282 | PMC8769337.
Soveg FW, Schwerk J, Gokhale NS, Cerosaletti K, Smith JR, Pairo-Castineira E, Kell AM, Forero A, Zaver SA, Esser-Nobis K, Roby JA, Hsiang TY, Ozarkar S, Clingan JM, McAnarney ET, Stone AE, Malhotra U, Speake C, Perez J, Balu C, Allenspach EJ, Hyde JL, Menachery VD, Sarkar SN, Woodward JJ, Stetson DB, Baillie JK, Buckner JH, Gale M Jr, Savan R. Endomembrane targeting of human OAS1 p46 augments antiviral activity. Elife. 2021 Aug 3;10:e71047. doi: 10.7554/eLife.71047. PMID: 34342578 | PMC8357416
Ylescupidez A, Rips A, Bahnson HT, Speake C, Verma P, Hocking AM, Buckner JH, Malhotra U. Early Prognostic Indicators of Subsequent Hospitalization in Patients with Mild COVID-19. J Clin Med. 2021 Apr 8;10(8):1562. doi: 10.3390/jcm10081562. PMID: 33917702 | PMC8068070
Bolouri H, Speake C, Skibinski D, Long SA, Hocking AM, Campbell DJ, Hamerman JA, Malhotra U, Buckner JH; Benaroya Research Institute COVID-19 Research Team. The COVID-19 immune landscape is dynamically and reversibly correlated with disease severity. J Clin Invest. 2021 Feb 1;131(3):e143648. doi: 10.1172/JCI143648. PMID: 33529167 | PMC7843226
DeGottardi Q, Gates TJ, Yang J, James EA, Malhotra U, Chow IT, Simoni Y, Fehlings M, Newell EW, DeBerg HA, Kwok WW. Ontogeny of different subsets of yellow fever virus-specific circulatory CXCR5+ CD4+ T cells after yellow fever vaccination. Sci Rep. 2020 Sep 24;10(1):15686. doi: 10.1038/s41598-020-72610-6. PMID: 32973217 | PMC7519049
Thompson O, Pierce D, Whang D, O'Malley M, Geise B, Malhotra U. Acute limb ischemia as sole initial manifestation of SARS-CoV-2 infection. J Vasc Surg Cases Innov Tech. 2020 Dec;6(4):511-513. doi: 10.1016/j.jvscit.2020.07.017. PMID: 32864520 | PMC7441972
Kates OS, Haydel BM, Florman SS, Rana MM, Chaudhry ZS, Ramesh MS, Safa K, Kotton CN, Blumberg EA, Besharatian BD, Tanna SD, Ison MG, Malinis M, Azar MM, Rakita RM, Morilla JA, Majeed A, Sait AS, Spaggiari M, Hemmige V, Mehta SA, Neumann H, Badami A, Goldman JD, Lala A, Hemmersbach-Miller M, McCort ME, Bajrovic V, Ortiz-Bautista C, Friedman-Moraco R, Sehgal S, Lease ED, Fisher CE, Limaye AP; UW COVID-19 SOT Study Team. Coronavirus Disease 2019 in Solid Organ Transplant: A Multicenter Cohort Study. Clin Infect Dis. 2021 Dec 6;73(11):e4090-e4099. doi: 10.1093/cid/ciaa1097. PMID: 32766815 | PMC7454362
Goldman JD, Lye DCB, Hui DS, Marks KM, Bruno R, Montejano R, Spinner CD, Galli M, Ahn MY, Nahass RG, Chen YS, SenGupta D, Hyland RH, Osinusi AO, Cao H, Blair C, Wei X, Gaggar A, Brainard DM, Towner WJ, Muñoz J, Mullane KM, Marty FM, Tashima KT, Diaz G, Subramanian A; GS-US-540-5773 Investigators. Remdesivir for 5 or 10 Days in Patients with Severe Covid-19. N Engl J Med. 2020 Nov 5;383(19):1827-1837. doi: 10.1056/NEJMoa2015301. PMID: 32459919 | PMC7377062
D'Angeli M, Baker J, Call D, Davis M, Kauber K, Malhotra U, Matsuura G, Moore D, Porter C, Pottinger P, Stockwell VO, Wagner C, Wohrle R, Yoder J, Yoke L, Rabinowitz P. 2016. Antimicrobial stewardship through a one health lens: Observations from Washington State. International Journal of Health Governance Information. 21(3):114-130. 2016
James EA, Gates TJ, LaFond RE, Yamamoto S, Ni C, Mai D, Gersuk VH, O'Brien K, Nguyen QA, Zeitner B, Lanteri MC, Norris PJ, Chaussabel D, Malhotra U, Kwok WW. Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome. PLoS Pathog. 2016 Jan 21;12(1):e1005375. doi: 10.1371/journal.ppat.1005375. PMID: 26795118 | PMC4721872
Malhotra U, Aboulafia DM. Cyclophosphamide Treatment for Acquired Factor VIII Inhibitor in a Patient with AIDS-Associated Progressive Multifocal Leukoencephalopathy. J Int Assoc Provid AIDS Care. 2016 Mar-Apr;15(2):109-13. doi: 10.1177/2325957415586259. PMID: 26013248
Yang J, James E, Gates TJ, DeLong JH, LaFond RE, Malhotra U, Kwok WW. CD4+ T cells recognize unique and conserved 2009 H1N1 influenza hemagglutinin epitopes after natural infection and vaccination. Int Immunol. 2013 Aug;25(8):447-57. doi: 10.1093/intimm/dxt005. PMID: 23524391 | PMC3720064
James EA, LaFond RE, Gates TJ, Mai DT, Malhotra U, Kwok WW. Yellow fever vaccination elicits broad functional CD4+ T cell responses that recognize structural and nonstructural proteins. J Virol. 2013 Dec;87(23):12794-804. doi: 10.1128/JVI.01160-13. PMID: 24049183 | PMC3838168
Rakita RM, Malhotra U. Widespread availability of artemisinin monotherapy in the United States. Emerg Infect Dis. 2011 May;17(5):954-5. doi: 10.3201/eid1705.101532. PMID: 21529430 | PMC3321780
Malhotra U, Nolin J, Horton H, Li F, Corey L, Mullins JI, McElrath MJ. Functional properties and epitope characteristics of T-cells recognizing natural HIV-1 variants. Vaccine. 2009 Nov 12;27(48):6678-87. doi: 10.1016/j.vaccine.2009.08.093. PMID: 19747576 | PMC2845637
[Malhotra U, Rakita R, Fernandez F, Harris G, Arguin P, Bronzan R, Slutsker L, Green M, Townes D] Centers for Disease Control and Prevention (CDC). Hepatitis temporally associated with an herbal supplement containing artemisinin - Washington, 2008. MMWR Morb Mortal Wkly Rep. 2009 Aug 14;58(31):854-6. PMID: 19680221
Mendiratta S, Vajpayee M, Malhotra U, Kaushik S, Dar L, Mojumdar K, Chauhan NK, Sreenivas V. Characterization of Gag and Nef-specific ELISpot-based CTL responses in HIV-1 infected Indian individuals. Med Microbiol Immunol. 2009 Feb;198(1):47-56. doi: 10.1007/s00430-008-0104-3. PMID: 18985383
Woolfrey AE, Malhotra U, Harrington RD, McNevin J, Manley TJ, Riddell SR, Coombs RW, Appelbaum FR, Corey L, Storb R. Generation of HIV-1-specific CD8+ cell responses following allogeneic hematopoietic cell transplantation. Blood. 2008 Oct 15;112(8):3484-7. doi: 10.1182/blood-2008-05-157511. PMID: 18698002 | PMC2569185
Li F, McKenney DM, Malhotra U, Crimi C, Nolin J, Corey L, McElrath JM, Newman MJ, Self SG. Towards prediction of degenerate CTL epitope recognition. Hum Vaccin. 2008 Mar-Apr;4(2):115-21. doi: 10.4161/hv.4.2.5215. PMID: 18382130
Malhotra U, Li F, Nolin J, Allison M, Zhao H, Mullins JI, Self S, McElrath MJ. Enhanced detection of human immunodeficiency virus type 1 (HIV-1) Nef-specific T cells recognizing multiple variants in early HIV-1 infection. J Virol. 2007 May;81(10):5225-37. doi: 10.1128/JVI.02564-06. PMID: 17329342 | PMC1900243
Malhotra U, Nolin J, Mullins JI, McElrath MJ. Comprehensive epitope analysis of cross-clade Gag-specific T-cell responses in individuals with early HIV-1 infection in the US epidemic. Vaccine. 2007 Jan 4;25(2):381-90. doi: 10.1016/j.vaccine.2006.07.045. Epub 2006 Aug 10. PMID: 17112643
Li F, Malhotra U, Gilbert PB, Hawkins NR, Duerr AC, McElrath JM, Corey L, Self SG. Peptide selection for human immunodeficiency virus type 1 CTL-based vaccine evaluation. Vaccine. 2006 Nov 17;24(47-48):6893-904. doi: 10.1016/j.vaccine.2006.06.009. PMID: 16890329
Stekler J, Maenza J, Stevens C, Holte S, Malhotra U, McElrath MJ, Corey L, Collier AC. Abacavir hypersensitivity reaction in primary HIV infection. AIDS. 2006 Jun 12;20(9):1269-74. doi: 10.1097/01.aids.0000232234.19006.a2. PMID: 16816555
Malhotra U, Huntsberry C, Holte S, Lee J, Corey L, McElrath MJ. CD4+ T cell receptor repertoire perturbations in HIV-1 infection: association with plasma viremia and disease progression. Clin Immunol. 2006 Apr;119(1):95-102. doi: 10.1016/j.clim.2005.11.010. PMID: 16403675
Malhotra U, Bosch RJ, Wang R, Collier A, McElrath MJ. Effect of adjunct hydroxyurea on helper T cell immunity in HIV type 1-infected patients with virological suppression. AIDS Res Hum Retroviruses. 2004 Aug;20(8):807-12. doi: 10.1089/0889222041725226. PMID: 15320983
Chien PC Jr, Chen D, Chen PD, Tuen M, Cohen S, Migueles SA, Connors M, Rosenberg E, Malhotra U, Gonzalez C, Hioe CE. HIV-1-infected patients with envelope-specific lymphoproliferation or long-term nonprogression lack antibodies suppressing glycoprotein 120 antigen presentation. J Infect Dis. 2004 Mar 1;189(5):852-61. doi: 10.1086/380133. PMID: 14976603
Malhotra U, Bosch RJ, Chan E, Wang R, Fischl MA, Collier AC, McElrath MJ. Association of T cell proliferative responses and phenotype with virus control in chronic progressive HIV-1 disease. J Infect Dis. 2004 Feb 1;189(3):515-9. doi: 10.1086/381038. PMID: 14745710
Cao J, McNevin J, Malhotra U, McElrath MJ. Evolution of CD8+ T cell immunity and viral escape following acute HIV-1 infection. J Immunol. 2003 Oct 1;171(7):3837-46. doi: 10.4049/jimmunol.171.7.3837. PMID: 14500685
Malhotra U, Holte S, Zhu T, Delpit E, Huntsberry C, Sette A, Shankarappa R, Maenza J, Corey L, McElrath MJ. Early induction and maintenance of Env-specific T-helper cells following human immunodeficiency virus type 1 infection. J Virol. 2003 Feb;77(4):2663-74. doi: 10.1128/jvi.77.4.2663-2674.2003. PMID: 12552005 | PMC141076.
Geisler WM, Malhotra U, Stamm WE. Pneumonia and sepsis due to fluoroquinolone-resistant Capnocytophaga gingivalis after autologous stem cell transplantation. Bone Marrow Transplant. 2001 Dec;28(12):1171-3. doi: 10.1038/sj.bmt.1703288. PMID: 11803363
Malhotra U, Holte S, Dutta S, Berrey MM, Delpit E, Koelle DM, Sette A, Corey L, McElrath MJ. Role for HLA class II molecules in HIV-1 suppression and cellular immunity following antiretroviral treatment. J Clin Invest. 2001 Feb;107(4):505-17. doi: 10.1172/JCI11275. PMID: 11181650 | PMC199253
Malhotra U, Berrey MM, Huang Y, Markee J, Brown DJ, Ap S, Musey L, Schacker T, Corey L, McElrath MJ. Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection. J Infect Dis. 2000 Jan;181(1):121-31. doi: 10.1086/315202. PMID: 10608758
Burns JL, Malhotra U, Lingappa J, Smith S. Unusual presentations of nontuberculous mycobacterial infections in children. Pediatr Infect Dis J. 1997 Aug;16(8):802-6. doi: 10.1097/00006454-199708000-00013. PMID: 9271044
Marx M, Meyer S, Malhotra U. Thrombus deformation of inferior vena caval filter. AJR Am J Roentgenol. 1995 Mar;164(3):771-2. doi: 10.2214/ajr.164.3.7863923. PMID: 7863923
Malhotra U, Spielman R, Concannon P. Variability in T cell receptor V beta gene usage in human peripheral blood lymphocytes. Studies of identical twins, siblings, and insulin-dependent diabetes mellitus patients. J Immunol. 1992 Sep 1;149(5):1802-8. PMID: 1387153
Malhotra U, Concannon P. T cell receptor beta gene polymorphism and rheumatoid arthritis. Autoimmunity. 1992;12(2):75-7. doi: 10.3109/08916939209150312. PMID: 1352153
Nepom BS, Malhotra U, Schwarz DA, Nettles JW, Schaller JG, Concannon P. HLA and T cell receptor polymorphisms in pauciarticular-onset juvenile rheumatoid arthritis. Arthritis Rheum. 1991 Oct;34(10):1260-7. doi: 10.1002/art.1780341009. PMID: 1930315
Sanal O, Wei S, Foroud T, Malhotra U, Concannon P, Charmley P, Salser W, Lange K, Gatti RA. Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region. Am J Hum Genet. 1990 Nov;47(5):860-6. PMID: 2220826 | PMC1683694
Malhotra U, Concannon P. An anonymous marker [HGM provisional #D11S415] maps to human chromosome 11 near the catalase (CAT) gene. Nucleic Acids Res. 1990 Jan 25;18(2):386. doi: 10.1093/nar/18.2.386. PMID: 1970166 | PMC330303
Concannon P, Malhotra U, Charmley P, Reynolds J, Lange K, Gatti RA. The ataxia-telangiectasia gene (ATA) on chromosome II is distinct from the ETS-1 gene. Am J Hum Genet. 1990 Apr;46(4):789-94. PMID: 1969227 | PMC1683674
Charmley P, Wei S, Sanal O, Malhotra U, Concannon P, Terhorst C, Gatti RA. Human T-cell receptor CD3-gamma (CD3G)/MspI DNA polymorphism. Nucleic Acids Res. 1989 Mar 25;17(6):2372. doi: 10.1093/nar/17.6.2372. PMID: 2468133 | PMC317620
Malhotra U, Concannon P. Human T-cell receptor CD3-delta (CD3D)/MspI DNA polymorphism. Nucleic Acids Res. 1989 Mar 25;17(6):2373. doi: 10.1093/nar/17.6.2373. PMID: 2468134 | PMC317621
Hingorani V, Malhotra U, Kumar S, Saraya L, Sunesh K, Buckshee K. An antiprogestin steroid and PGE2 for an early pregnancy termination. Acta Obstet Gynecol Scand Suppl. 1989;149:25-9. PMID: 2482650