Mridu Acharya, PhD
Dr. Acharya was born and raised in Nepal. She graduated with a BSc(Hons) degree from University of Hull, UK in 2003 and with a Masters in Research(MRes) degree from University of Glasgow in 2004. She received PhD in Biochemistry from University of Glasgow in 2008 and then moved to Massachusetts General Hospital/Harvard Medical School for postdoctoral training. In December 2013, she became a Staff Scientist at BRI and subsequently became Assistant Member in October 2016.
Area of Research
Dr. Acharya’s research interest is in understanding how signals from different types of immune receptors and cytoskeletal molecules are integrated to produce an immune response tailored to the type of antigen encountered. Currently she is using a combination of cell biology, mouse models and human immunology to study how B-lymphocytes of the immune system integrate these types of signals from antigens and their environment to produce effective responses to pathogens while maintaining tolerance to self-derived antigens. Using the samples available from BRI’s biorepositories, we are studying the mechanisms of B-lymphocyte activation by self-antigens during human autoimmune diseases such as systemic lupus erythematosus (SLE). In collaboration with Dr. Adam Lacy-Hulbert at BRI and Dr. David Rawlings at Seattle Children’s Research Institute we are also studying mechanisms regulating expansion of antigen specific B-lymphocytes and development of protective immunity in response to viral antigens.
Acharya M, Sokolovska A, Tam J, Conway K, Stefani C, Mukophadyaya S, Feliu M, Paul E, Hynes RO, Xavier R, Vyas J, Stuart LM , Lacy-Hulbert A. αv Integrins combine with LC3 and atg5 to regulate Toll-like Receptor signaling in B cells. Nat Commun. 2016 Mar 11;7:10917. doi: 10.1038/ncomms10917. PMID: 26965188
Tam JM, Mansour MK, Acharya M, Sokolovska A, Timmons AK, Lacy-Hulbert A and Vyas JM. The role of autophagy-related proteins in Candida albicans infections. Pathogens. 2016 Mar 29;5(2). pii: E34. doi: 10.3390/pathogens5020034. PMID: 27043636
Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM. Dectin-1-dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages. Journal of Infectious Diseases. J Infect Dis. 2014 Dec 1;210(11):1844-54. doi: 10.1093/infdis/jiu290. PMID: 24842831 (featured on cover).
Overstreet MG, Gaylo A, Angermann BR, Hughson A, Hyun YM, Lambert K, Acharya M, Billroth-Maclurg AC, Rosenberg AF, Topham DJ, Yagita H, Kim M, Lacy-Hulbert A, Meier-Schellersheim M, Fowell DJ. Inflammation-induced interstitial migration of effector CD4(+) T cells is dependent on integrin alphaV. Nat Immunol. 2013 Sep;14(9):949-58. doi: 10.1038/ni.2682. PMID: 23933892
Acharya M, Mukhopadhyay S, Paidassi H, Jamil T, Chow C, Kissler S, Stuart LM, Hynes RO, Lacy-Hulbert A. alphav Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J Clin Invest. 2010 Dec;120(12):4445-52. doi: 10.1172/JCI43796. PMID: 21099114