Thomas N. Wight, PhD

Director, Matrix Biology Program; Member
Office Phone: 
206-287-5666

Background Information

Dr. Wight completed his undergraduate degree at the University of Maine and his PhD in Zoology at the University of New Hampshire. Following his post-doctoral training in the Department of Pathology at the University of Washington in Seattle, he moved back to New England and joined the faculty in Cell Biology at the University of New Hampshire as an Assistant Professor. He rejoined the Department of Pathology at the University of Washington in 1979 and was promoted to Full Professor in 1988.  In 2004, he joined the Benaroya Research Institute at Virginia Mason to begin a Program in Matrix Biology.  Dr. Wight has been named an Established Investigator of the American Heart Association, served on National Institutes of Health and American Heart Association Study Sections, and served on several editorial boards. Dr. Wight is a founding member of the International Society of Hyaluronan Sciences and he served as Chair of the Proteoglycan Gordon Conference in 2008. His research focuses on the role of proteoglycans in regulating cell phenotype and extracellular matrix assembly in immunity and inflammation. He has published over 350 articles on proteoglycans and hyaluronan. He is currently Director of the Matrix Biology Program at the Benaroya Research Institute at Virginia Mason and an Affiliate Professor of Pathology at the University of Washington School of Medicine.

Area of Research

Dr. Wight’s research focuses on the role of hyaluronan (HA), versican and other proteoglycans in the regulation of cell phenotype and extracellular matrix assembly in a variety of diseases including atherosclerosis, cancer and more recently asthma and autoimmune diseases such as type 1 diabetes and rheumatoid arthritis.  A current focus of his research is to explore mechanisms of how the extracellular matrix and its components, such as hyaluronan and versican, regulate immune cell phenotype and inflammation.

 

Dr. Wight's CV

Wight Laboratory

Matrix Biology Program