Adam Lacy-Hulbert, PhD
Background Information
Dr. Lacy-Hulbert received his BA degree in Natural Sciences (Biochemistry) and PhD in Biochemistry from the University of Cambridge. He trained as a postdoctoral fellow at University College London, and then moved to the University of Edinburgh, as a UK Research Council Fellow. Dr. Lacy-Hulbert spent 2003 to 2007 as a visiting scientist and then visiting professor at the Center for Cancer Research at Massachusetts Institute of Technology. In 2007, Dr. Lacy-Hulbert joined the Department of Pediatrics at Massachusetts General Hospital, as Assistant Professor at Harvard Medical School and Director of the Developmental Immunology Program. Dr. Lacy-Hulbert moved his laboratory to the Benaroya Research Institute in 2013.
Area of Research
The overall research objectives of the Lacy-Hulbert Laboratory are to understand the mechanisms by which innate immune cells, such as macrophages and dendritic cells, regulate immunity and tolerance. The laboratory team uses a range of molecular and cell biology approaches, in isolated cells and whole organisms, to approach these important problems. The group has a longstanding interest in how the recognition of dying cells promotes immune tolerance and tissue repair, and the role of a specific family of cell adhesion molecules, the alpha-v Integrins, in this process. A major focus of the laboratory is how breakdown of these mechanisms can lead to inflammatory bowel disease (IBD) and autoimmunity.
In a joint program with BRI Affiliate Investigator Lynda Stuart, MD, PhD, and her group, the laboratory team also works to discover new mechanisms by which cells recognize and resist infection.
Featured Publications
Bruchez A, Sha K, Johnson J, Chen L, Stefani C, McConnell H, Gaucherand L, Prins R, Matreyek KA, Hume AJ, Mühlberger E, Schmidt EV, Olinger GG, Stuart LM, Lacy-Hulbert A. MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses. Science. 2020 Oct 9;370(6513):241-247. doi: 10.1126/science.abb3753. PMID: 32855215 | PMC7665841
Acharya M, Raso F, Sagadiev S, Gilbertson E, Kadavy L, Li QZ, Yan M, Stuart LM, Hamerman JA, Lacy-Hulbert A. B Cell αv Integrins Regulate TLR-Driven Autoimmunity. J Immunol. 2020 Oct 1;205(7):1810-1818. Doi: 10.4049/jimmunol.1901056. PMID: 32859730 | PMC7504890.
Zhang A, Lacy-Hulbert A, Anderton S, Haslett C, Savill J. Apoptotic Cell-Directed Resolution of Lung Inflammation Requires Myeloid αv Integrin-Mediated Induction of Regulatory T Lymphocytes. Am J Pathol. 2020 Jun;190(6):1224-1235. Doi: 10.1016/j.ajpath.2020.02.010. PMID: 32201264 | PMC7254048
Akilesh HM, Buechler MB, Duggan JM, Hahn WO, Matta B, Sun X, Gessay G, Whalen E, Mason M, Presnell SR, Elkon KB, Lacy-Hulbert A, Barnes BJ, Pepper M, Hamerman JA. Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes. Science. 2019 Jan 11;363(6423):eaao5213. Doi: 10.1126/science.aao5213. PMID: 30630901 | PMC6413693
Mani V, Bromley SK, Äijö T, Mora-Buch R, Carrizosa E, Warner RD, Hamze M, Sen DR, Chasse AY, Lorant A, Griffith JW, Rahimi RA, McEntee CP, Jeffrey KL, Marangoni F, Travis MA, Lacy-Hulbert A, Luster AD, Mempel TR. Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate. Science. 2019 Oct 11;366(6462):eaav5728. Doi: 10.1126/science.aav5728. PMID: 31601741 | PMC6939608
Schrock DC, Leddon SA, Hughson A, Miller J, Lacy-Hulbert A, Fowell DJ. Pivotal role for αV integrins in sustained Tfh support of the germinal center response for long-lived plasma cell generation. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4462-4470. Doi: 10.1073/pnas.1809329116. PMID: 30770452 | PMC6410787
Raso F, Sagadiev S, Du S, Gage E, Arkatkar T, Metzler G, Stuart LM, Orr MT, Rawlings DJ, Jackson SW, Lacy-Hulbert A, Acharya M. αv Integrins regulate germinal center B cell responses through noncanonical autophagy. J Clin Invest. 2018 Aug 31;128(9):4163-4178. Doi: 10.1172/JCI99597. PMID: 29999501 | PMC6118577
Acharya M, Sokolovska A, Tam JM, Conway KL, Stefani C, Raso F, Mukhopadhyay S, Feliu M, Paul E, Savill J, Hynes RO, Xavier RJ, Vyas JM, Stuart LM, Lacy-Hulbert A. αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells. Nat Commun. 2016 Mar 11;7:10917. Doi: 10.1038/ncomms10917. PMID: 26965188 | PMC4792966
Boucard-Jourdin M, Kugler D, Endale Ahanda ML, This S, De Calisto J, Zhang A, Mora JR, Stuart LM, Savill J, Lacy-Hulbert A, Paidassi H. β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage. J Immunol. 2016 Sep 1;197(5):1968-78. Doi: 10.4049/jimmunol.1600244. PMID: 27481847 | PMC4992650
Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM. Dectin-1-dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages. J Infect Dis. 2014 Dec 1;210(11):1844-54. Doi: 10.1093/infdis/jiu290. PMID: 24842831 | PMC4271056
Overstreet MG, Gaylo A, Angermann BR, Hughson A, Hyun YM, Lambert K, Acharya M, Billroth-Maclurg AC, Rosenberg AF, Topham DJ, Yagita H, Kim M, Lacy-Hulbert A, Meier-Schellersheim M, Fowell DJ. Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV. Nat Immunol. 2013 Sep;14(9):949-58. Doi: 10.1038/ni.2682. PMID: 23933892 | PMC4159184
Chen L, Stuart L, Ohsumi TK, Burgess S, Varshney GK, Dastur A, Borowsky M, Benes C, Lacy-Hulbert A, Schmidt EV. Transposon activation mutagenesis as a screening tool for identifying resistance to cancer therapeutics. BMC Cancer. 2013 Feb 27;13:93. Doi: 10.1186/1471-2407-13-93. PMID: 23442791 | PMC3598783
Païdassi H, Acharya M, Zhang A, Mukhopadhyay S, Kwon M, Chow C, Stuart LM, Savill J, Lacy-Hulbert A. Preferential expression of integrin αvβ8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells. Gastroenterology. 2011 Nov;141(5):1813-20. Doi: 10.1053/j.gastro.2011.06.076. PMID: 21745448 | PMC3202651
Acharya M, Mukhopadhyay S, Païdassi H, Jamil T, Chow C, Kissler S, Stuart LM, Hynes RO, Lacy-Hulbert A. αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J Clin Invest. 2010 Dec;120(12):4445-52. Doi: 10.1172/JCI43796. PMID: 21099114 | PMC2993596
Lacy-Hulbert A, Smith AM, Tissire H, Barry M, Crowley D, Bronson RT, Roes JT, Savill JS, Hynes RO. Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15823-8. Doi: 10.1073/pnas.0707421104. PMID: 17895374 | PMC1994135
Lacy-Hulbert A, Ueno T, Ito T, Jurewicz M, Izawa A, Smith RN, Chase CM, Tanaka K, Fiorina P, Russell PS, Auchincloss H Jr, Sayegh MH, Hynes RO, Abdi R. Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection. Am J Transplant. 2007 May;7(5):1080-90. Doi: 10.1111/j.1600-6143.2007.01757.x. | PMID: 17359504
Lucas M, Stuart LM, Zhang A, Hodivala-Dilke K, Febbraio M, Silverstein R, Savill J, Lacy-Hulbert A. Requirements for apoptotic cell contact in regulation of macrophage responses. J Immunol. 2006 Sep 15;177(6):4047-54. Doi: 10.4049/jimmunol.177.6.4047. PMID: 16951368
Lucas M, Stuart LM, Savill J, Lacy-Hulbert A. Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion. J Immunol. 2003 Sep 1;171(5):2610-5. Doi: 10.4049/jimmunol.171.5.2610. PMID: 12928413
Stuart LM, Lucas M, Simpson C, Lamb J, Savill J, Lacy-Hulbert A. Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation. J Immunol. 2002 Feb 15;168(4):1627-35. Doi: 10.4049/jimmunol.168.4.1627. PMID: 11823490
List Of Published Work
To view a full list of published work, please visit the National Center for Biotechnology Information library of medicine at pubmed.gov.