Recent Publications

The following list highlights BRI's 2022 publications. More selective listings of publications are also included on scientist biography pages. BRI Principal Investigators are listed in bold.

Al-Shaikhly T, Murphy RC, Parker A, Lai Y, Altman MC, Larmore M, Altemeier WA, Frevert CW, Debley JS, Piliponsky AM, Ziegler SF, Peters MC, Hallstrand TS. Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma. Eur Respir J. 2022 Jan 13:2101865. Doi: 10.1183/13993003.01865-2021. PMID: 35027395

Bajzik V, DeBerg HA, Garabatos N, Rust BJ, Obrien KK, Nguyen QA, O’Rourke C, Smith A, Walker AH, Quinn C, Gersuk VH, Farrington M, Jeong D, Vickery BP, Adelman DC, Wambre E. Oral desensitization therapy for peanut allergy induces dynamic changes in peanut-specific immune responses. Allergy. 2022 Mar 10. Doi: 10.1111/all.15276. PMID: 35266148

Buckner JH, Harrison OJ. Th17 cells: from gut homeostasis to CNS pathogenesis. Trends Immunol. 2022 Mar;43(3):167-169. Doi: 10.1016/j.it.2022.01.005. PMID: 35058150

Cable J, Rappuoli R, Klemm EJ, Kang G, Mutreja A, Wright GJ, Pizza M, Castro SA, Hoffmann JP, Alter G, Carfi A, Pollard AJ, Krammer F, Gupta RK, Wagner CE, Machado V, Modjarrad K, Corey L, B Gilbert P, Dougan G, Lurie N, Bjorkman PJ, Chiu C, Nemes E, Gordon SB, Steer AC, Rudel T, Blish CA, Sandberg JT, Brennan K, Klugman KP, Stuart LM, Madhi SA, Karp CL. Innovative vaccine approaches-a Keystone Symposia report. Ann N Y Acad Sci. 2022 Jan 14. Doi: 10.1111/nyas.14739. PMID: 35029310

Gong KQ, Mikacenic C, Long ME, Frevert C, Birkland TP, Charron J, Gharib SA, Manicone AM. MAP2K2 Delays Recovery in Murine Models of Acute Lung Injury and Associates with ARDS Outcome. Am J Respir Cell Mol Biol. 2022 Feb 14. Doi: 10.1165/rcmb.2021-0252OC. PMID: 35157553

Ishigaki K, Lagattuta KA, Luo Y, James EA, Buckner JH, Raychaudhuri S. HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors. Nat Genet. 2022 Mar 24. Doi: 10.1038/s41588-022-01032-z. PMID: 35332318

Jing Y, Kong Y, McGinty J, Blahnik-Fagan G, Lee T, Orozco-Figueroa S, Bettini ML, James EA, Bettini M. TCR/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Post-translationally Modified GAD65 Epitope. Diabetes. 2022 Feb 18:db210993. Doi: 10.2337/db21-0993. PMID: 35179565

Jones BE, Maerz MD, Bahnson HT, Somasundaram A, McCarthy LH, Speake C, Buckner JH. Fewer LAG-3+ T Cells in Relapsing-Remitting Multiple Sclerosis and Type 1 Diabetes. J Immunol. 2022 Feb 1;208(3):594-602. Doi: 10.4049/jimmunol.2100850. PMID: 35022272 | PMC8820445

Kanchan K, Grinek S, Bahnson HT, Ruczinski I, Shankar G, Larson D, Du Toit G, Barnes KC, Sampson HA, Suarez-Farinas M, Lack G, Nepom GT, Cerosaletti K, Mathias RA. HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy. J Clin Invest. 2022 Jan 4;132(1):e152070. Doi: 10.1172/JCI152070. PMID: 34981778 | PMC8718139

Lambert K, Moo KG, Arnett A, Goel G, Hu A, Flynn KJ, Speake C, Wiedeman AE, Gersuk VH, Linsley PS, Greenbaum CJ, Long SA, Partridge R, Buckner JH, Khor B. Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity. Sci Transl Med. 2022 Jan 12;14(627):eabi4888. Doi: 10.1126/scitranslmed.abi4888. PMID: 35020411

McCauley KE, Flynn K, Calatroni A, DiMassa V, LaMere B, Fadrosh DW, Lynch KV, Gill MA, Pongracic JA, Khurana Hershey GK, Kercsmar CM, Liu AH, Johnson CC, Kim H, Kattan M, O’Connor GT, Bacharier LB, Teach SJ, Gergen PJ, Wheatley LM, Togias A, LeBeau P, Presnell S, Boushey HA, Busse WW, Gern JE, Jackson DJ, Altman MC, Lynch SV; National Institute of Allergy and Infectious Diseases–sponsored Inner-City Asthma Consortium. Seasonal airway microbiome and transcriptome interactions promote childhood asthma exacerbations. J Allergy Clin Immunol. 2022 Feb 8:S0091-6749(22)00146-4. Doi: 10.1016/j.jaci.2022.01.020. PMID: 35149044

Santos AF, Evans E, O’Rourke C, Bahnson HT, Lack G. Reply. J Allergy Clin Immunol. 2022 Mar;149(3):1129-1131. Doi: 10.1016/j.jaci.2021.12.766. PMID: 35000772

Shannon JL, Corcoran DL, Murray JC, Ziegler SF, MacLeod AS, Zhang JY. Thymic stromal lymphopoietin controls hair growth. Stem Cell Reports. 2022 Mar 8;17(3):649-663. Doi: 10.1016/j.stemcr.2022.01.017. PMID: 35216683

Sims EK, Besser REJ, Dayan C, Geno Rasmussen C, Greenbaum CJ, Griffin KJ, Hagopian W, Knip M, Long AE, Martin F, Mathieu C, Rewers M, Steck AK, Wentworth JM, Rich SS, Kordonouri O, Ziegler AG, Herold KC; NIDDK Type 1 Diabetes TrialNet Study Group. Screening for Type 1 Diabetes in the General Population: A Status Report and Perspective. Diabetes. 2022 Apr 1;71(4):610-623. Doi: 10.2337/dbi20-0054. PMID: 35316839

So M, O’Rourke C, Ylescupidez A, Bahnson HT, Steck AK, Wentworth JM, Bruggeman BS, Lord S, Greenbaum CJ, Speake C. Characterising the age-dependent effects of risk factors on type 1 diabetes progression. Diabetologia. 2022 Apr;65(4):684-694. Doi: 10.1007/s00125-021-05647-5. PMID: 35041021

Yang JHM, Ward-Hartstonge KA, Perry DJ, Blanchfield JL, Posgai AL, Wiedeman AE, Diggins K, Rahman A, Tree TIM, Brusko TM, Levings MK, James EA, Kent SC, Speake C, Homann D, Long SA; Immunology of Diabetes Society T-Cell Cytometry Group. Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes. Eur J Immunol. 2022 Mar;52(3):372-388. Doi: 10.1002/eji.202049067. PMID: 35025103

Yuzefpolskiy Y, Morawski P, Fahning M, Speake C, Lord S, Chaudhary A, Morishima C, Wener MH, Kita M, McCarthy L, Buckner JH, Campbell DJ, Bettelli E. Cutting Edge: Effect of Disease-Modifying Therapies on SARS-CoV-2 Vaccine-Induced Immune Responses in Multiple Sclerosis Patients. J Immunol. 2022 Apr 1;208(7):1519-1524. Doi: 10.4049/jimmunol.2101142. PMID: 35288472