Recent Publications

The following list highlights BRI's 2020 publications. More selective listings of publications are also included on scientist biography pages. BRI Principal Investigators are listed in bold.

  1. Abdelsamed HA, Zebley CC, Nguyen H, Rutishauser RL, Fan Y, Ghoneim HE, Crawford JC, Alfei F, Alli S, Ribeiro SP, Castellaw AH, McGargill MA, Jin H, Boi SK, Speake C, Serti E, Turka LA, Busch ME, Stone M, Deeks SG, Sekaly RP, Zehn D, James EA, Nepom GT, Youngblood B. Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes. Nat Immunol. 2020 Mar 30. doi: 10.1038/s41590-020-0633-5. PMID: 32231298

  2. Arribas-Layton D, Guyer P, Delong T, Dang M, Chow IT, Speake C, Greenbaum CJ, Kwok WW, Baker RL, Haskins K, James EA. Hybrid Insulin Peptides are Recognized by Human T Cells in the Context of DRB1*04:01. Diabetes. 2020 Apr 14. pii: db190620. doi: 10.2337/db19-0620. PMID: 32291282 | PMC7306133

  3. Barretto KT, Brockman-Schneider RA, Kuipers I, Basnet S, Bochkov YA, Altman MC, Jarjour NN, Gern JE, Esnault S. Human Airway Epithelial Cells Express a Functional IL-5 Receptor. Allergy 2020 Apr 4. doi: 10.1111/all.14297. PMID: 32246831

  4. Berkson JD, Slichter CK, DeBerg HA, Delaney MA, Woodward-Davis AS, Maurice NJ, Lwo Y, Ko A, Hsu J, Chiu YW, Linsley PS, Dixon D, Prlic M. Inflammatory Cytokines Induce Sustained CTLA-4 Cell Surface Expression on Human MAIT Cells. Immunohorizons. 2020 Jan 23;4(1):14-22. doi: 10.4049/immunohorizons.1900061. PMID: 31974109

  5. Bogdani M, Speake C, Dufort MJ, Johnson PY, Larmore MJ, Day AJ, Wight TN, Lernmark Å, Greenbaum CJ. Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates. Diabetologia. 2020 Jan 6. doi: 10.1007/s00125-019-05066-7. PMID: 31907557 | PMC7002022

  6. Bogun MM, Bundy BN, Goland RS, Greenbaum CJ. C-Peptide Levels in Subjects Followed Longitudinally Before and After Type 1 Diabetes Diagnosis in TrialNet. Diabetes Care. 2020 May 26;dc192288. doi: 10.2337/dc19-2288. PMID: 32457058

  7. Bolouri H, Young M, Beilke J, Johnson R, Fox B, Huang L, Santini CC, Hill CM, Vries AVV, Shannon PT, Dervan A, Sivakumar P, Trotter M, Bassett D, Ratushny A. Integrative network modeling reveals mechanisms underlying T cell exhaustion. Sci Rep. 2020 Feb 5;10(1):1915. doi: 10.1038/s41598-020-58600-8. PMID: 32024856 | PMC7002445

  8. Brilland B, Scherlinger M, Khoryati L, Goret J, Duffau P, Lazaro E, Charrier M, Guillotin V, Richez C, Blanco P. Platelets and IgE: Shaping the Innate Immune Response in Systemic Lupus Erythematosus. Clin Rev Allergy Immunol. 2020 Apr;58(2):194-212. doi: 10.1007/s12016-019-08744-x. PMID: 31254159

  9. Brough HA, Nadeau KC, Sindher SB, Alkotob SS, Chan S, Bahnson H, Leung DYM, Lack G. Epicutaneous sensitization in the development of food allergy: what is the evidence and how can this be prevented? Allergy. 2020 Apr 6. doi: 10.1111/all.14304. Review. PMID: 32249942

  10. Carmona-Rivera C, Carlucci PM, Goel RR, James EA, Brooks SR, Rims CR, Hoffmann V, Fox DA, Buckner JH, Kaplan MJ. Neutrophil Extracellular Traps Mediate Articular Cartilage Damage and Enhance Cartilage Component Immunogenicity in Rheumatoid Arthritis. 2020 Jul 9;5(13):139388. doi: 10.1172/jci.insight.139388. PMID: 32484790

  11. Caumont F, Porter C, DeBerg H, Burns J, Frankel J, Flores JP. Combined chemotherapy and radiotherapy improves survival in 1897 testicular Lymphoma patients from a contemporary cohort. Urol Oncol. 2020 Apr 16. pii: S1078-1439(20)30082-X. doi: 10.1016/j.urolonc.2020.02.027. PMID: 32307328

  12. Chen AC, Cai X, Li C, Khoryati L, Gavin MA, Miao CH. A Treg-Selective IL-2 Mutein Prevents the Formation of Factor VIII Inhibitors in Hemophilia Mice Treated With Factor VIII Gene Therapy. Front Immunol . 2020 Apr 28;11:638. doi: 10.3389/fimmu.2020.00638. eCollection 2020. PMID: 32411127 | PMC7198749

  13. Glatigny S, Höllbacher B, Motley SJ, Tan C, Hundhausen C, Buckner JH, Smilek D, Khoury SJ, Ding L, Qin T, Pardo J, Nepom GT, Turka LA, Harris KM, Campbell DJ, Bettelli E. Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance. J Immunol 2019 Mar 1;202(5):1373-1382. doi: 10.4049/jimmunol.1801425. Epub 2019 Jan 25. PMID: 30683697 | PMC6481683

  14. Gratz IK, Campbell DJ. Resident memory T cells show that it is never too late to change your ways. Nat Immunol. 2020 Apr;21(4):359-360. doi: 10.1038/s41590-020-0637-1. PMID: 32205885

  15. Harten IA, Kaber G, Agarwal KJ, Kang I, Ibarrientos SR, Workman G, Chan CK, Nivison MP, Nagy N, Braun KR, Kinsella MG, Merrilees MJ, Wight TN. The Synthesis and Secretion of Versican Isoform V3 by Mammalian Cells: A Role for N-linked Glycosylation. Matrix Biol. 2020 Jan 27. pii: S0945-053X(20)30008-1. doi: 10.1016/j.matbio.2020.01.002. PMID: 32001344

  16. Honaker Y, Hubbard N, Xiang Y, Fisher L, Hagin D, Sommer K, Song Y, Yang SJ, Lopez C, Tappen T, Dam EM, Khan I, Hale M, Buckner JH, Scharenberg AM, Torgerson TR, Rawlings DJ. Gene Editing to Induce FOXP3 Expression in Human CD4 + T Cells Leads to a Stable Regulatory Phenotype and Function. Sci Transl Med . 2020 Jun 3;12(546):eaay6422. doi: 10.1126/scitranslmed.aay6422. PMID: 32493794

  17. Hurabielle C, Link VM, Bouladoux N, Han SJ, Merrill ED, Lightfoot YL, Seto N, Bleck CKE, Smelkinson M, Harrison OJ, Linehan JL, Tamoutounour S, Lionakis MS, Kaplan MJ, Nakajima S, Belkaid Y. Immunity to Commensal Skin Fungi Promotes Psoriasiform Skin Inflammation. Proc Natl Acad Sci U S A. 2020 Jun 29:202003022. doi: 10.1073/pnas.2003022117. PMID: 32601220.

  18. Jackson DJ, Busse WW, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Visness CM, Durham SR, Larson D, Esnault S, Ober C, Gergen PJ, Becker P, Togias A, Gern JE, Altman MC. Association of Respiratory Allergy, Asthma and Expression of the SARS-CoV-2 Receptor, ACE2. J Allergy Clin Immunol. 2020 Apr 22. pii: S0091-6749(20)30551-0. doi: 10.1016/j.jaci.2020.04.009. PMID: 32333915 | PMC7175851

  19. James EA, Mallone R, Kent SC, DiLorenzo TP. T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal. JCI Insight. 2020 Jun 23:136579. doi: 10.1172/jci.insight.136579. PMID: 32561620 | PMC7306130

  20. Kabata H, Flamar AL, Mahlakõiv T, Moriyama S, Rodewald HR, Ziegler SF, Artis D. Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation. Mucosal Immunol. 2020 Feb 17. doi: 10.1038/s41385-020-0266-x. PMID: 32066836

  21. Kitajima M, Kubo M, Ziegler SF, Suzuki H. Critical Role of TSLP Receptor on CD4 T Cells for Exacerbation of Skin Inflammation. J Immunol . 2020 May 22;ji1900758. doi: 10.4049/jimmunol.1900758. PMID: 32444388

  22. Lai JF, Thompson LJ, Ziegler SF. TSLP drives acute Th2 differentiation in lungs. J Allergy Clin Immunol. 2020 Apr 15. pii: S0091-6749(20)30484-X. doi: 10.1016/j.jaci.2020.03.032. PMID: 32304753

  23. Lande R, Palazzo R, Gestermann N, Jandus C, Falchi M, Spadaro F, Riccieri V, James EA, Butera A, Boirivant M, Feldmeyer L, Surbeck I, Di Lucca J, Stuber F, Spinelli FR, Botti E, Marinari B, Bianchi L, Pica R, Cerbelli B, Giannakakis K, Auteri SE, Daniels I, Durrant LG, Horstman S, Costanzo A, Romero P, Alessandri C, Conti F, Valesini G, Gilliet M, Chizzolini C, Frasca L. Native/citrullinated LL37-specific T-cells help autoantibody production in Systemic Lupus Erythematosus. Sci Rep. 2020 Apr 3;10(1):5851. doi: 10.1038/s41598-020-62480-3. PMID: 32245990 | PMC7125190

  24. Larson D, Patel P, Salapatek AM, Couroux P, Whitehouse D, Pina A, Johnson JL, Sever ML, Sanda S, Poyser J, Allio T, Scadding GW, Qin T, Shamji MH, Kwok WW, James EA, French D, Lelic A, Larché M, Altman MC, Togias A, Durham SR. Nasal Allergen Challenge and Environmental Exposure Chamber Challenge: A Randomized Trial Comparing Clinical and Biological Responses to Cat Allergen. J Allergy Clin Immunol. 2020 Jun;145(6):1585-1597. doi: 10.1016/j.jaci.2020.02.024. Epub 2020 Mar 10. PMID: 32169380

  25. Leyva-Castillo JM, Galand C, Mashiko S, Bissonnette R, McGurk A, Ziegler SF, Dong C, McKenzie ANJ, Sarfati M, Geha RS. ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation. J Allergy Clin Immunol. 2020 Jun;145(6):1606-1614.e4. doi: 10.1016/j.jaci.2020.02.026. Epub 2020 Mar 14. PMID: 32179159

  26. Li D, Matta B, Song S, Nelson V, Diggins K, Simpfendorfer KR, Gregersen PK, Linsley P, Barnes BJ. IRF5 genetic risk variants drive myeloid-specific IRF5 hyperactivation and presymptomatic SLE. JCI Insight. 2020 Jan 30;5(2). pii: 124020. doi: 10.1172/jci.insight.124020. PMID: 31877114

  27. Muehling LM, Heymann PW, Wright PW, Eccles JD, Agrawal R, Carper HT, Murphy DD, Workman LJ, Word CR, Ratcliffe SJ, Capaldo BJ, Platts-Mills TAE, Turner RB, Kwok WW, Woodfolk JA. Human Th1 and Th2 Cells Targeting Rhinovirus and Allergen Coordinately Promote Allergic Asthma. J Allergy Clin Immunol. 2020 Apr 19. pii: S0091-6749(20)30494-2. doi: 10.1016/j.jaci.2020.03.037. PMID: 32320734

  28. Neiman D, Gillis D, Piyanzin S, Cohen D, Fridlich O, Moss J, Zick A, Oron T, Sundberg F, Forsander G, Skog O, Korsgren O, Levy-Khademi F, Arbell D, Hashavya S, Shapiro AMJ, Speake C, Greenbaum C, Hosford J, Posgai A, Atkinson MA, Glaser B, Schatz D, Shemer R, Dor Y. Multiplexing DNA Methylation Markers to Detect Circulating Cell-Free DNA Derived From Human Pancreatic Beta-Cells. JCI Insight. 2020 Jun 23;136579. doi: 10.1172/jci.insight.136579. PMID: 32573495

  29. Ober C, McKennan CG, Magnaye KM, Altman MC, Washington C 3rd, Stanhope C, Naughton KA, Rosasco MG, Bacharier LB, Billheimer D, Gold DR, Gress L, Hartert T, Havstad S, Khurana Hershey GK, Hallmark B, Hogarth DK, Jackson DJ, Johnson CC, Kattan M, Lemanske RF, Lynch SV, Mendonca EA, Miller RL, Naureckas ET, O'Connor GT, Seroogy CM, Wegienka G, White SR, Wood RA, Wright AL, Zoratti EM, Martinez FD, Ownby D, Nicolae DL, Levin AM, Gern JE; Environmental Influences on Child Health Outcomes-Children's Respiratory Research Workgroup. Expression Quantitative Trait Locus Fine Mapping of the 17q12-21 Asthma Locus in African American Children: A Genetic Association and Gene Expression Study. Lancet Respir Med 2020 May;8(5):482-492. doi: 10.1016/S2213-2600(20)30011-4. PMID: 32380068 | PMC7335429

  30. Omori-Miyake M, Watarai H, Sato K, Ziegler SF, Yagi J. An Accumulation of Two Populations of Dendritic Cells in Skin-Draining Lymph Nodes in Response to the Expression of Thymic Stromal Lymphopoietin in the Skin. Cell Immunol . 2020 Jul;353:104116. doi: 10.1016/j.cellimm.2020.104116. Epub 2020 Apr 29. PMID: 32380184

  31. Pattwell SS, Arora S, Cimino PJ, Ozawa T, Szulzewsky F, Hoellerbauer P, Bonifert T, Hoffstrom BG, Boiani NE, Bolouri H, Correnti CE, Oldrini B, Silber JR, Squatrito M, Paddison PJ, Holland EC. A Kinase-Deficient NTRK2 Splice Variant Predominates in Glioma and Amplifies Several Oncogenic Signaling Pathways. Nat Commun2020 Jun 12;11(1):2977. doi: 10.1038/s41467-020-16786-5. PMID: 32532995 | PMC7293284

  32. Perkin MR, Bahnson HT, Lack G; EAT Study Team. Reply. J Allergy Clin Immunol. 2020 Feb 25. pii: S0091-6749(20)30103-2. doi: 10.1016/j.jaci.2020.01.015. PMID: 32111420

  33. Reeves SR, Barrow KA, Rich LM, White MP, Shubin NJ, Chan CK, Kang I, Ziegler SF, Piliponsky AM, Wight TN, Debley JS. Respiratory Syncytial Virus Infection of Human Lung Fibroblasts Induces a Hyaluronan-Enriched Extracellular Matrix That Binds Mast Cells and Enhances Expression of Mast Cell Proteases. Front Immunol. 2020 Jan 28;10:3159. doi: 10.3389/fimmu.2019.03159. PMID: 32047499 | PMC6997473

  34. Rickels MR, Evans-Molina C, Bahnson HT, Ylescupidez A, Nadeau KJ, Hao W, Clements MA, Sherr JL, Pratley RE, Hannon TS, Shah VN, Miller KM, Greenbaum CJ; T1D Exchange β-Cell Function Study Group. High Residual C-peptide Likely Contributes to Glycemic Control in Type 1 Diabetes. J Clin Invest . 2020 Apr 1;130(4):1850-1862. doi: 10.1172/JCI134057. PMID: 31895699 | PMC7108933

  35. Rodrigues KB, Dufort MJ, Llibre A, Speake C, Rahman MJ, Bondet V, Quiel J, Linsley PS, Greenbaum CJ, Duffy D, Tarbell KV. Innate Immune Stimulation of Whole Blood Reveals IFN-1 Hyper-Responsiveness in Type 1 Diabetes. Diabetologia 2020 Jun 5. doi: 10.1007/s00125-020-05179-4. PMID: 32500289

  36. Rost F, Lambert K, Rakebrandt N, Joller N. Preceding Viral Infections Do Not Imprint Long-Term Changes in Regulatory T Cell Function. Sci Rep. 2020 May 20;10(1):8350. doi: 10.1038/s41598-020-65212-9. PMID: 32433493 | PMC7239864

  37. Santos AF, Barbosa-Morais NL, Hurlburt BK, Ramaswamy S, Hemmings O, Kwok M, O'Rourke C, Bahnson HT, Cheng H, James L, Gould HJ, Sutton BJ, Maleki SJ, Lack G. IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2-specific IgE. Allergy. 2020 Apr 4. doi: 10.1111/all.14301. PMID: 32248566

  38. Santos AF, Du Toit G, O'Rourke C, Becares N, Couto-Francisco N, Radulovic S, Khaleva E, Basting M, Harris KM, Larson D, Sayre P, Plaut M, Roberts G, Bahnson HT, Lack G. Biomarkers of severity and threshold of allergic reactions during oral peanut challenges. J Allergy Clin Immunol. 2020 Apr 17. pii: S0091-6749(20)30490-5. doi: 10.1016/j.jaci.2020.03.035. PMID: 32311390

  39. Schorer M, Lambert K, Rakebrandt N, Rost F, Kao KC, Yermanos A, Spörri R, Oderbolz J, Raeber ME, Keller CW, Lünemann JD, Rogler G, Boyman O, Oxenius A, Joller N. Rapid expansion of Treg cells protects from collateral colitis following a viral trigger. Nat Commun. 2020 Mar 23;11(1):1522. doi: 10.103. PMID: 32251280 | PMC7090079

  40. Sheih A, Voillet V, Hanafi LA, DeBerg HA, Yajima M, Hawkins R, Gersuk V, Riddell SR, Maloney DG, Wohlfahrt ME, Pande D, Enstrom MR, Kiem HP, Adair JE, Gottardo R, Linsley PS, Turtle CJ. Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy. Nat Commun. 2020 Jan 10;11(1):219. doi: 10.1038/s41467-019-13880-1. PMID: 31924795 | PMC6954177

  41. Shubin NJ, Clauson M, Niino K, Kasprzak V, Tsuha A, Guga E, Bhise G, Acharya M, Snyder JM, Debley JS, Ziegler SF, Piliponsky AM. Thymic stromal lymphopoietin protects in a model of airway damage and inflammation via regulation of caspase-1 activity and apoptosis inhibition. Mucosal Immunol. 2020 Feb 26. doi: 10.1038/s41385-020-0271-0. PMID: 32103153

  42. Sindher S, Alkotob SS, Shojinaga MN, Brough HA, Bahnson T, S C, Lack G, Leung DYM, Nadeau KC. Pilot study measuring transepidermal water loss (TEWL) in children suggests trilipid cream is more effective than a paraffin-based emollient. Allergy. 2020 Mar 16. doi: 10.1111/all.14275. PMID: 32176320

  43. So M, O'Rourke C, Bahnson HT, Greenbaum CJ, Speake C. Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody-Positive Individuals. Diabetes Care. 2020 Feb 4. pii: dc191731. doi: 10.2337/dc19-1731. PMID: 32019856

  44. Speake C, Ylescupidez A, Neiman D, Shemer R, Glaser B, Tersey SA, Usmani-Brown S, Clark P, Wilhelm JJ, Bellin MD, Herold KC, Mirmira RG, Dor Y, Evans-Molina C. Circulating unmethylated insulin DNA as a biomarker of human beta cell death: a multi-laboratory assay comparison. J Clin Endocrinol Metab. 2020 Jan 8. pii: dgaa008. doi: 10.1210/clinem/dgaa008. PMID: 31913467 | PMC7015459

  45. Wang L, Kikuchi S, Schmidt TA, Hoofnagle M, Wight TN, Azuma N, Tang GL, Sobel M, Velamoor GR, Mokadam NA, Kenagy RD. Inhibitory Effects of PRG4 on Migration and Proliferation of Human Venous Cells. J Surg Res. 2020 Apr 19;253:53-62. doi: 10.1016/j.jss.2020.03.028. PMID: 32320897

  46. Wang X, Balaji S, Steen EH, Blum AJ, Li H, Chan CK, Manson SR, Lu TC, Rae MM, Austin PF, Wight TN, Bollyky PL, Cheng J, Keswani SG. High Molecular Weight Hyaluronan Attenuates Tubulointerstitial Scarring in Kidney Injury. JCI Insight . 2020 May 12;136345. doi: 10.1172/jci.insight.136345. PMID: 32396531

  47. Wen X, Yang J, James E, Chow IT, Reijonen H, Kwok WW. Increased islet antigen-specific regulatory and effector CD4+ T cells in healthy individuals with the type 1 diabetes-protective haplotype. Sci Immunol. 2020 Feb 14;5(44). pii: eaax8767. doi: 10.1126/sciimmunol.aax8767. PMID: 32060144

  48. Wiedeman AE, Muir VS, Rosasco MG, DeBerg HA, Presnell S, Haas B, Dufort MJ, Speake C, Greenbaum CJ, Serti E, Nepom GT, Blahnik G, Kus AM, James EA, Linsley PS, Long SA. Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression. J Clin Invest. 2020 Jan 2;130(1):480-490. doi: 10.1172/JCI126595. PMID: 31815738 | PMC6934185

  49. Wight TN, Kang I, Evanko SP, Harten IA, Chang MY, Pearce OMT, Allen CE, Frevert CW. Versican-A Critical Extracellular Matrix Regulator of Immunity and Inflammation. Front Immunol. 2020 Mar 24;11:512. doi: 10.3389/fimmu.2020.00512. eCollection 2020. PMID: 32265939 | PMC7105702

  50. Zhang A, Lacy-Hulbert A, Anderton S, Haslett C, Savill J. Apoptotic cell-directed resolution of lung inflammation requires myeloid αv integrin-mediated induction of regulatory T lymphocytes. Am J Pathol. 2020 Mar 19. pii: S0002-9440(20)30131-0. doi: 10.1016/j.ajpath.2020.02.010. PMID: 32201264

  51. Zhao LP, Papadopoulos GK, Kwok WW, Moustakas AK, Bondinas GP, Larsson HE, Ludvigsson J, Marcus C, Samuelsson U, Wang R, Pyo CW, Nelson WC, Geraghty DE, Lernmark Å. Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association with the Risk of Type 1 Diabetes in DQ2 and DQ8 Children. Diabetes. 2020 Apr 3. pii: db200075. doi: 10.2337/db20-0075. PMID: 32245799