Benaroya Research Institute (BRI) is on a mission to predict, prevent, reverse and cure immune system diseases. We study the cells and processes within the immune system, how and why immune system diseases start, and how to rebalance the immune system back to health. Our focus spans a wide variety of immune system diseases – including autoimmune diseases, asthma, allergy, cancer and COVID-19 – with the goal of transforming our understanding of how to prevent and treat these conditions.
Collaboration defines our work. We build teams within our institute and with partners around the world to take on some of the most difficult questions in immunology. This approach moves us closer to our vision of a healthy immune system for everyone.
Our Centers of Discovery: A pipeline from lab research to life-changing care
BRI’s research is organized around four Centers of Discovery, allowing us to accelerate advances at every stage of our work. Our centers enable us to make discoveries in the lab and provide a foundation for new and innovative therapies. They also help us to take questions directly from the clinic — such as what makes a therapy work for one person and not another — back to our labs to find meaningful answers.
Our Biorepositories
BRI is home to 11 biorepositories with thousands of blood and tissue samples that have been donated to science, spanning 20 different immune system diseases as well as healthy controls. Access to human samples allows us to closely study diseases in the lab, make new insights, and bring those insights to patient care faster.
Our Core Labs: Building and using the latest tools and technologies
Our Core Labs enable our scientists to build and use some of the most innovative tools in immunology that allow for advanced imaging, data sequencing and exploring the human genome. Each core is led by an expert in their field. Scientists across BRI and from other institutes can partner with these experts to leverage these tools and fuel discoveries in all areas of research.
Our Team: Together we discover
Collaboration is one of BRI’s core values, and our team is our biggest asset. We have built our organization to facilitate teamwork across disease areas, with experts working across fields and with partners around the globe. Shared resources like our Core Labs, Clinical Research Center and biorepositories fuel discoveries across our institute.
Featured Publications
Jul 2025
Identification of immunogenic commensal antigens using phage display.
Nat Protoc
Verma S, Kimmel S, Harrison OJ
Jul 2025
Transcriptional fingerprinting of regulatory T cells: ensuring quality in cell therapy applications.
Front Immunol
Cheng Z, Wang LJ, Honaker Y, Cincotta SA, Page CE, Vollhardt S, Yuan V, Long SA, Xiao Y, Beilke JN, Arron JR, Bluestone JA
Jul 2025
Immunization with full-length TprC variants induces a broad response to surface-exposed epitopes of the Treponema pallidum repeat protein family and is partially protective in the rabbit model of syphilis.
Vaccine
Giacani L, Romeis E, Haynes A, Molini BJ, Tantalo LC, Xu LH, Trejos AT, Keane J, Mohamed Z, Armstrong TD, Wieland BA, Phung Q, Vyshenska D, Campbell VL, Godornes C, Koelle DM, Reid TB, Wang Y, Vorobieva AA, Wald A, Lieberman NAP, Greninger AL
Jul 2025
A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rβ deficiency.
Cell Rep
Cabrera-Martinez B, Garcia-Perez JE, Baxter RM, Lui VG, Ghosh T, Eken A, Kostka-Newman Z, Garcia JRM, Rahkola J, Gessner RL, Dutmer CM, Klarquist J, Pietras EM, Ghosh D, Johnson SA, Kedl RM, Hsieh EWY
Jul 2025
Expanding the Case for Hybrid Insulin Peptides in Type 1 Diabetes.
Diabetes
Cerosaletti K, Kent SC
