Macrophages in the lung consist of alveolar macrophages and interstitial macrophages. These cells have been implicated in driving pathologic lung inflammation, participating in repair and contributing to fibrosis.
We are studying macrophage heterogeneity through single cell RNA sequencing, spatial transcriptomics and high dimensional cytometry. Our research focuses on both acute disease, like hypoxemic respiratory failure in the intensive care unit, as well as chronic lung diseases like fibrosis associated with autoimmune disease, hypersensitivity pneumonitis or other interstitial lung diseases.
These studies will identify how macrophage subsets contribute to acute and chronic inflammatory lung diseases.