In the News
Healio, June 15, 2017
Oral insulin therapy fails to prevent type 1 diabetes, but some see disease delay
In adults with two or more antibodies predicting the development of type 1 diabetes, treatment with daily oral insulin therapy did not prevent development of the disease, but a small subset experienced a 31-month delay in clinical diabetes development.
Diabetes.com.uk, June 15, 2017
Oral insulin trial fails to meet endpoint, but could help delay type 1 diabetes
Oral insulin has shown to be unsuccessful in preventing the development of type 1 diabetes in a new trial, but it did help delay the onset. The trial found that oral insulin led to some people experiencing a 31-month delay in the clinical development of type 1 diabetes, a finding hailed as "dramatic" by researchers.
EurekAlert!, March 30, 2017
Lupus Researchc Alliance Novel Research Grant push discoveries
The Lupus Research Alliance announced today the Novel Research Grant Class of 2017. BRI's Mridu Acharya, PhD, was awarded a grant for her work on proteins that normally work together to prevent B cells from attacking patients' cells. She is working with human B Cells to investigate why these proteins fail to put on the brakes in lupus and will investigate potential new treatments to get them working properly again.
StreetInsider.com, March 16, 2017
'Patient lives are at stake,' Fred Hutch president says of 'devastating' Trump cuts
President Donald Trump’s 2018 budget proposal slashes funding by 18 percent for the National Institutes of Health, a critical funding source for Seattle's world-renowned research centers.
Thanks in large part to organizations like the Fred Hutchinson Cancer Research Center, the University of Washington and Benaroya Research Institute, Washington state and the Pacific Northwest have become known as the place where groundbreaking cancer research is done. Those researchers depend on funding from the NIH. Washington state ranks No. 8 in the nation for the amount of funding that comes from the NIH, receiving a total of $952.8 million in 2016.
StreetInsider.com, March 6, 2017
Aimmune Therapeutics (AIMT) Presents Data on Phase 3 Screening and Phase 2 Adherence for AR101 for Peanut Allergy at AAAAI
Aimmune Therapeutics, Inc., a biopharmaceutical company developing treatments for life-threatening food allergies, announced clinical data presented today at the 2017 American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting in Atlanta. The presentations included Phase 3 screening data and Phase 2 adherence data from Aimmune’s AR101 program. AR101 is Aimmune’s investigational biologic oral immunotherapy for desensitization of patients with peanut allergy. Also at the AAAAI meeting, Blake Rust, Ph.D., and Erik Wambre, Ph.D., of the Benaroya Research Institute at Virginia Mason (BRI) presented data on peanut-specific effector and regulatory T cells in a blinded subset of samples from patients screened for PALISADE.
Yahoo Finance, March 4, 2017
AnaptysBio Announces Data from Scientific Collaboration with the Benaroya Research Institute Presented at the AAAAI 2017 Annual Meeting
AnaptysBio, Inc. (ANAB), a clinical-stage biotechnology company developing first-in-class antibody product candidates focused on unmet medical needs in inflammation, today announced that its scientific collaborators at the Benaroya Research Institute at Virginia Mason (BRI) have presented a translational research study entitled “Role of IL-33 in modulating human allergen-specific pathogenic CD4+T Cell responses,” at the American Academy of Allergy, Asthma and Immunology (AAAAI) 2017 Annual Meeting.
This study, conducted in the laboratory of Dr. Erik Wambre at BRI, assessed the biology of a distinct subset of T cells, called TH2A cells, which are found in elevated frequency in peanut allergic patients when compared to non-allergic individuals. The research concluded that IL-33 is a key checkpoint of allergic responses, and blocking IL-33 has the potential to reduce expression of the effector cytokines involved in severe peanut allergy.
Crosscut.com, January 30, 2017
A Northwest medical mystery — and the hunt for answers
Scientists don’t know why, exactly, autoimmune diseases are becoming more common. They don’t know why exactly we’re more prone to autoimmune diseases in the Pacific Northwest, or sometimes even how to quickly and accurately diagnose them. Which is why every Tuesday morning when Dr. Jane Buckner makes her weekly visit to her clinic in Seattle’s First Hill neighborhood, she braces herself for questions to which she might not know the answer. Starting with the very basics: “What’s wrong with me?”
Buckner is a rheumatologist and also the director of the Benaroya Research Institute at Virginia Mason, a Seattle-based organization dedicated to researching the full suite of over 80 types of autoimmune diseases. By examining autoimmune diseases with particular attention to their similarities, rather than their differences, Benaroya has found its way to the cutting edge of immunology research.
Puget Sound Business Journal, January 6, 2017
51 New Seattle-area CEOs
Dr. Jane Buckner, president of the Benaroya Research Institute at Virginia Mason: Buckner was at Benaroya for 16 years before replacing Dr. Gerald Nepom as president, previously serving as assitant director. She has been recognized for her research on genetic causes of auto-immune diseases.
Puget Sound Business Journal, January 6, 2017
People in Research: Benaroya's immunology director pursues and important molecule
A coin flip started Steven Ziegler's long career studying an underlying factor in allergies, asthma and eczema. The data Ziegler has collected on the molecule, called TSLP, has been shared with biopharmaceutical giant Amgen over the years, which now has a drug to block TSLP function going through a phase 2 trial.
CNN, January 5, 2017
New peanut allergy prevention guidelines start in infancy
New peanut allergy prevention guidelines were created by an expert panel from the American Academy of Pediatrics, the American Academy of Family Physicians, the American Academy of Allergy, Asthma & Immunology in conjunction with the National Institute of Allergy and Infectious Diseases. The new guidlelines are based on the These new guidelines are based on the results of the LEAP (Learning Early About Peanut) study. The study was conducted by the Immune Tolerance Network (ITN), which is BRI's largest program, and made news back in February of 2015. In this article, Jerry Nepom, MD, PhD, BRI member and ITN director, discusses the significance of the LEAP study.
Puget Sound Business Journal, December 6, 2016
People in Research: Lynn Rose manages Benaroya partnerships with drug makers
The collaboration between research institutions and pharmaceutical companies is unknown to many, but Lynn Rose says those relationships are critical to getting a drug in a bottle and ready for patients. As pharmaceutical companies reduce their research and development workforces, they are increasingly partnering with research institutes to help with the early stages of development. This, Rose said, allows the drug companies to do what they do best: clinical trials and product development.
FierceBiotech.com, November 18, 2016
Tired T cells hamper cancer treatment, but could be a boon for diabetes drug
While T cell exhaustion can hinder cancer treatments, a Benaroya Research Institute-led team has discovered that T cell fatigue may potentially boost therapies for diabetes and other autoimmune diseases. Immune T cells burn out and become less effective when they are overworked, so scientists working on cancer immunotherapies are seeking to bypass this phenomenon. But a new study found that T cells with similar qualities to fatigued T cells are associated with a positive response to the diabetes drug Teplizumab.
TheVerge.com, November 2, 2016
Is the future of peanut allergy treatment a wearable patch?
A new skin patch for treating peanut allergies has been getting a lot of attention. A couple companies are developing therapies designed to blunt dangerous allergic reactions by slowly reducing an allergic person's sensitivity to peanut protein. Though both treatments look promising, there’s still a long way to go, says Gerald Nepom, an immunologist at the Benaroya Research Institute in Washington State. Neither the patch nor the pill are FDA-approved yet, but both have recently wrapped up Phase II clinical trials that assessed the efficacy and safety of the treatments. And both products will now be tested in larger Phase III trials.
Puget Sound Business Journal, October 21, 2016
Accelerator Corp. partners with Fred Hutch, UW to spur biotech startup scene
Accelerator Corp., a Seattle-based investment and management company that focuses on biotech startups, has partnered with the University of Washington’s CoMotion and Fred Hutchinson Cancer Research Center. Accelerator Corp. will provide Fred Hutch and CoMotion with startup resources to run an early-stage biotech company. Existing research partners in Washington include Benaroya Research Institute, Seattle Children’s Hospital and Washington State University.
King5 News, October 4, 2016
$8 million in funding to fight asthma given to local researchers
The National Institute of Allergy and Infectious Diseases has awarded Benaroya Research Institute at Virginia Mason a five-year, $8 million grant to lead a cooperative study on the immune system’s responses to allergens in the lungs. Over the next five years, investigators at BRI, UW Medicine, and Seattle Children’s Research Institute will collaborate to gain insights into the lung epithelium – the interface between the inside of the lung and the outside environment – to inform the development of new treatments and therapies for allergies and asthma. One in four people in the United States are allergic, asthmatic, or both. In this King5 News segment, Steven Ziegler, PhD, discusses the research that he will lead as part of this NIH grant.
STAT, September 15, 2016
Lab Chat: How inflammation might drive diabetes
Dr. Jane Buckner discusses recent findings, published in Science Translational Medicine that suggest the signaling molecule IL-6 may be involved in inflammation that could drive the progression of type 1 diabetes. Scientists at BRI found that when they exposed T cells to IL-6 the T cells changed and became more likely to go into healthy tissue. In type 1 diabetes, that tissue would be the pancreas. Therapeutics that block IL-6 are already used for other diseases and may provide an approach to stop the progression of type 1 diabetes.
Q13 News, August 25, 2016
EpiPen price hike drawing local criticism, highlighting need for more research
Dr. Jane Buckner discusses why more research is so important in light of the recent EpiPen price hike. Currently EpiPens are criticial for those who suffer from allergies. However with new research uncovering why people develop allergies, she hopes that one day we will be able to prevent these diseases or cure them and we won't need to rely on EpiPens. BRI recently recieved an $8 million grant from the National Institute of Allergy and Infectious Diseases to lead research in this area.
New Day Northwest King 5, August 25, 2016
Promising research for food allergies
BRI's Dr. Erik Wambre and Virginia Mason physician Dr. David Jeong discuss BRI's unique approach to allergy research, the great progress that is being made in understanding how allergies develop and their hope for a future vaccine.
Geekwire, August 23, 2016
New solutions for allergies and asthma? Seattle collaboration lands $8M grant to research treatments
For those with allergies and asthma, one small particle can mean hours of wheezing, sneezing, and runny eyes and noses. About a quarter of Americans suffer from allergies, asthma, or both, but we still know very little about the origins and mechanics of these conditions.
A new collaboration between Virginia Mason’s Benaroya Research Institute, Seattle Children’s Research Institute and University of Washington Medicine hopes to change that. The project will study respiratory epithelium, a tissue that lines the inside of our lungs, and may result in new treatments for asthma and allergies.
Puget Sound Business Journal, August 23, 2016
Benaroya Research Institute receives $8M to research new asthma treatments
The Benaroya Research Institute at Virginia Mason has received an $8 million grant to lead a collaborative study that could eventually lead to asthma and allergy treatments.
Over the next five years, BRI researchers will work with researchers at UW Medicine and Seattle Children's Research Institute to study the immune system's responses to allergens in the lungs, which will inform the development of new treatments and therapies for allergies and asthma.
Puget Sound Business Journal, August 19, 2016
People in Research: Personal vendetta fuels scientist’s work
As early as 8 years old, when anyone asked Eddie James, PhD, what he wanted to do when he grew up, the answer was the same. "I want to be a scientist and do experiments." Unlike many people, James followed through on that young promise and is now one of the foremost researchers at the Beneroya Reserach Institute at Virginia Mason.
When his dad got sick and was fighting kidney cancer, there was no treatment for it. "It impressed upon me that there are people out there that standard care just can't help. We need therapies and I wanted to be part of it."
While he "held a grudge" against cancer, his roomate at WSU and niece both had type 1 diabetes, showing him firsthand the "difficulty of managing and living with that disease." That lead him to form a new "personal vendetta" against type 1 diabetes....read more
Puget Sound Business Journal, June 8, 2016
Sen. Murray touts deal to boost medical research funding by $2 billion
U.S. Sen. Patty Murray says she has nailed down a bipartisan deal to boost funding for the National Institutes of Health next year by $2 billion.
Because Washington state ranks No. 8 in the nation for the amount of NIH funding it receives, a $2 billion increase could mean a significant bump in funding for the state. In 2015, Washington was awarded $885 million in total funding. It still has to be considered by the full appropriations committee next week, but the agreement was bipartisan, which gives Murray hope it will pass, already announcing the budget has been secured.
Top regional research facilities such as the University of Washington, Fred Hutchinson Cancer Research Center and the Benaroya Research Institute at Virginia Mason depend on funding from the NIH for support to work on medical innovations.
Puget Sound Business Journal, June 3, 2016
People in Research: Dr. James Lord Takes 17,000 Steps Toward a Cure
From a research perspective, cancer and autoimmune diseases like IBD are not that far apart - both involve studying people's own immune systems. In cancer, researchers are figuring out how to use the immune system to attack a person's own tumor. With autoimmune diseases, researchers are trying to find ways to prevent the immune system from attacking a person - "opposite sides of the same coin," Lord said.
Lord started at Benaroya Research Institute at Virginia Mason in 2010 and is the founder of the institute's inflammatory bowel disease biorepository, where he has collected more than 17,000 samples that will help researchers answer questions that could one day lead to a cure for diseases such as IBD.
Seattle Magazine, June, 2016 issue
Research Alters Allergy Approach
A new study published in The New England Journal of Medicine, designed and funded in Seattle by Benaroya Research Institute at Virginia Mason and the Immune Tolerance Network, indicates that feeding peanuts to infants at risk of developing an allergy to peanuts can help prevent allergy development, even after those infants stop eating peanuts. This study is an extension of last year’s landmark LEAP (Learning Early About Peanut Allergy) study, which showed that early consumption of peanuts by infants with existing food sensitivities reduced the rate of developing peanut allergy by 80 percent. The research is altering the way physicians approach this life-threatening allergy.
BuisinessWire.com, May 16, 2016
Aimmune Therapeutics Announces First Quarter 2016 Financial Results and Provides Corporate Update
As part of Aimmune Therapeutics research retreat and quarterly corportate update, Erik Wambre, PhD, of Benaroya Research Institute presented recent research from his lab focusing on peanut specific Th2 lymphocytes. His talk included data from a small pilot study of participants in Aimmune’s Phase 2 trials, which he previously presented at AAAAI in March. In these preliminary studies, activated peanut-specific Th2 cells were greatly reduced in the blood of subjects receiving AR101, the company's lead product candidate, but not placebo, suggesting that AR101 specifically modulated key lymphocyte populations responsible for peanut allergy. Aimmune and BRI have an ongoing partnership and plan to expand these and other related studies during the Phase 3 PALISADE trial, with generous support from the Immune Tolerance Network.
DailyMail.com, May 16, 2016
Jelly Gives Sharks Their Deadly Supersense: Conductive Material Under Predators' Skin Helps Them Detect Their Prey's Movements
Sharks, skates, and rays can sense their prey by detecting electric fields. This involves an unusual set of organs known as the ampullae of Lorenzini. These organs contain a clear viscous jelly, which has now been studied. The jelly can conduct protons better than any known biological material. This discovery was published on May 13 in Science Advances, by a team of researchers from UC Santa Cruz, University of Washington, and Chris Amemiya, PhD, the Benaroya Research Institute at Virginia Mason.
The Rheumatologist, May 13, 2016
Rheumatolotists on the Move: Benaroya Research Institute Names New President
Jane Buckner, MD, is the new president of the Benaroya Research Institute (BRI) at Virginia Mason in Seattle. While she continues to see patients one day a week and work with her research group, as president, she says she “will work with the faculty to be sure they have what they need. I have the opportunity to step back and think more broadly. Do we need new technology or new people to make BRI better? All the science should be directed to what’s important to patients. The ultimate goal is to help patients.”
Phys.org, May 13, 2016
Proton-Conducting Material Found in Electrosensory Organs of Sharks
In a new study, published May 13 in Science Advances, a team of researchers from UC Santa Cruz, University of Washington, and Chris Amemiya, PhD, the Benaroya Research Institute at Virginia Mason investigated the properties of this jelly. They found that the jelly is a remarkable proton-conducting material, with the highest proton conductivity ever reported for a biological material. Its conductivity is only 40 times lower than the current state-of-the-art proton-conducting polymer (Nafion). The new findings may be of interest to researchers in materials science and other fields. An animation about the discovery produced by the American Association for the Advancement of Science is available at IBDTimes.co.uk.
Puget Sound Business Journal, May 6, 2016
People in Research: Moon Landing Inspired Her to Chase Diabetes Cure
Knowing that the Benaroya Research Institute at Virginia Mason in Seattle is the place to "understand what causes autoimmune diseases and learn targets to treat people," Greenbaum started with the nonprofit in 2000. She has been the director of the diabetes program there since 2005 and in her work now focuses mainly on type 1 diabetes.
Currently, the only treatment for type 1 diabetes is to give insulin to patients because their bodies cannot produce it. She is working on finding ways to prevent and cure type 1 diabetes.
Morningstar, Apr. 11, 2016
Aimmune Therapeutics Presents Data on Biomarkers and Potential to Predict Response to Peanut Allergy Treatment with AR101
Erik Wambre, PhD, of the Benaroya Research Institute (BRI) discussed research from his lab focusing on peanut-specific Th2 lymphocytes in a presentation at the annual Food Allergy Research and Education (FARE) Research Retreat. His talk included data from a small pilot study of participants in Aimmune’s Phase 2 trials. In these preliminary studies, activated peanut-specific Th2 cells were greatly reduced in the blood of subjects receiving active treatment, but not placebo, suggesting that AR101 specifically modulated key lymphocyte populations responsible for peanut allergy.
FinancialContent.com, Apr. 7, 2016
Helmsley Charitable Trust Awards $2.1 Million to Penn, Stanford and Seattle Children's Research Institute to Explore Cell-Based Therapies for Type 1 Diabetes
The Type 1 Diabetes (T1D) Program of The Leona M. and Harry B. Helmsley Charitable Trust has announced $2.1 million in grants to support research toward the creation of new T1D-specific cell therapies that could help delay or halt the progression of the disease. The new investment will support three complementary projects at the University of Pennsylvania, Stanford University and Seattle Children's Research Institute, which will collaborate with the Benaroya Research Institute.
On The Pulse, Mar. 22, 2016
Researchers Work Toward New Type 1 Diabetes Therapies For Patients Like Juliana
A new $1 million grant from The Leona M. and Harry B. Helmsley Charitable Trust will get doctors and scientists at BRI in collaboration with Seattle Children’s Research Institute one step closer to better treatment for type 1 diabetes by studying the use of immunotherapy to treat the condition.
Today.com, Mar. 4, 2016
Feeding kids peanuts prevents allergies long-term, study shows
A bold and controversial experiment that showed feeding peanuts to babies and young children could protect them from developing allergies later has shown long-term effects, doctors reported Friday. The children were largely protected a year after stopping peanuts. The study was conducted by the Immune Tolerance Network, which is led by BRI.
Puget Sound Business Journal, Mar. 3, 2016
Sen Murray introduces bill to restore medical research funding
Sen. Patty Murray, D-Washington, introduced a bill Thursday to create a new funding stream for the National Institutes of Health and the Food & Drug Administration in an effort to restore medical research funding around the country. Her plan is to create the National Biomedical Research Act that would provide $5 billion per year for select initiatives at the NIH and FDA, bringing the budget back up to where it was before.
National Institute of Allergy and Infectious Diseases, Jan. 25, 2015
Selected NIAID Research Advances of 2015
BRI leads the Immune Tolerance Network (ITN). The ITN’s LEAP and HALT-MS trials were included as two of the 15 highlighted topics in NIAID’s selected research advances for 2015.
New Day Northwest, Sept. 24, 2015
Can pregnancy and Multiple Sclerosis go together?
Mariko Kita, MD, Director, Virginia Mason Multpile Sclerosis Center and Clinical Investigator at BRI, discusses Multiple Sclerosis and the general worries that come with it. Dr. Kita explains that pregnancy and MS can go together, and can actually benefit the patient.
The Rhuematologist, Sept. 15, 2015
Rheumatologists on the Move, September, 2015
After 30 years, Gerald Nepom, MD, will leave his post as director of Benaroya Research Institute (BRI) Virginia Mason in Seattle. Dr. Nepom is credited with leading the institute in international prominence through research into rheumatoid arthritis, diabetes, multiple sclerosis, allergies and other immune-system disorders.
Stanford Medicine News Center, Sep. 14, 2015
Drug Prevents Type 1 Diabetes in Mice
A compound that blocks the synthesis of hyaluronan, a substance generally found in in all body tissue, protected mice from getting type 1 diabetes. The study was performed in collaboration with scientists at the Benaroya Research Institute under the direction of matrix biologist Thomas Wight, PhD, whose group Bollyky was associated with when the work began.
Puget Sound Business Journal, Aug. 25, 2015
The wine was flowing, helped raise $435,000 for Benaroya Research Institute at Virginia Mason
Warm and balmy, Aug. 21 was a perfect Friday evening for the Virginia Mason Foundation’s annual “Grapes on the Green,” a wine-centric, summer fundraiser for the Benaroya Research Institute at Virginia Mason. BRI is an international leader in immune system and autoimmune disease research.
New Day Northwest, Aug. 21, 2015
Why are Autoimmune Diseases so Prevalent in Women?
BRI Associate Director, Jane Buckner, MD, discusses autoimmune diseases; who is most vulnerable and possible cures.
Seattle Magazine, July 13, 2015
Why BRI is a Global Leader in Immune System Research
One in 20 Americans suffers from an autoimmune disease, such as multiple sclerosis or type 1 diabetes. Treating these patients was a founding goal of the immunology program at Benaroya Research Institute (BRI), which began 30 years ago under the guidance of Dr. Gerald Nepom. Now BRI is a global leader in immune system research, and in 2014 became the home of the Immune Tolerance Network, an international clinical research consortium with 178 sites worldwide.
PM360, July 7, 2015
ADA: Alefacept slows progress of type 1 diabetes 15 months post-treatment
BRI and Immune Tolerance Network (ITN) Director Gerald Nepom, MD, PhD, discusses an ITN study of Alefacept, an immunosuppressive biologic drug that appears to stem the progression of new-onset type 1 diabetes more than a year after therapy is stopped.
Puget Sound Business Journal, June 26, 2015
Meet new Benaroya boss: Buckner aims to expand auto-immune research
Dr. Jane Buckner learned from a legend. Now she’s preparing to replace him. Buckner will become president of Benaroya Research Institute at Virginia Mason at the end of this year, replacing Dr. Gerald Nepom.
Puget Sound Business Journal, June 22, 2015
Longtime Benaroya Research Institute boss to step down
Dr. Gerald Nepom will retire as director of Benaroya Research Institute at Virginia Mason at the end of this year. Nepom, who led the Seattle-based organization for 30 years, grew the institute into international prominence by leading research efforts into diabetes, multiple sclerosis, rheumatoid arthritis, allergies and other immune-system disorders. He will be replaced by Dr. Jane Buckner, who is now the institute’s associate director. She has been with the organization for 16 years.
Business Day, June 11, 2015
Arthritis Drug Could Help Diabetics Too
A BRI clininical trial, EXTEND, is testing whether a blockbuster arthritis drug can take on an even more dangerous disease: diabetes.
broadwayworld.com, June 4, 2015
Relapsing Polychondritis Awareness Foundation Releases Documentary 'RP The Ride of My Life'
The Relapsing Polychondritis Awareness and Support Foundation is proud to release its first documentary, "RP The Ride of My Life," chronicling one woman's journey to live life with purpose while suffering from Relapsing Polychondritis (RP), a rare autoimmune disease.
faccpnw.wix.com, May 21, 2015
Erik Wambre, PhD, wins 2015 Innovation Award from The French-American Chamber of Commerce of the Pacific Northwest
On Friday, May 15, At the First Annual French-American Business Awards Pacific Northwest, Erik Wambre, PhD, was presented with their Innovation Award, which recognizes an individual or company for a specific innovative service or product launched in 2010 or later, in any sector.
Digitaljournal.com, May 11, 2015
The Seattle Food Allergy Consortium Issues New Allergist Guidelines For Parents on Early Introduction of Peanuts to Help Prevent Peanut Allergy
The LEAP study findings strongly suggest pediatricians and parents need to change course and evaluate the benefit of "careful" early introduction of peanuts. To help with this process SeaFAC has issues a new set of parent guidelines to discuss with their pediatrician.
SwissInfo.ch, April 9, 2015
Roche's Arthritis Blockbuster Seen Holding Promise for Diabetes
Researchers at Benaroya Research Institute are testing Roche's Actemra (tocilizumab) in a new clinical trial to see whether the antibody-based therapy can help people with type 1 diabetes stop their body from attacking insulin-making cells.
Healthline, March 26, 2015
New Living BtioBank Matched Diabetes Patients with Researchers
Thanks to the new Living BioBank, established by the nonprofit T1D Exchange, finding clinical research to participate in can be as easy as filling out an online survey, and then being matched with trials for which you are best suited. The Living BioBank has its "base of operations," so to speak, at the Benaroya Research Institute at Virginia Mason in Seattle, WA -- meaning that's where participant enrollment is centralized, along with test kit sample collection and distribution to investigators around the U.S.
Seattle Magazine, February, 2015
Immunotherapy Research is Rebooting Seattle's Biotech Sector
Immune system research has always been an area of strength in Seattle and the immunotherapy market is booming. At the Benaroya Research Institute (BRI) at Virginia Mason, scientists are using immunotherapy to target type 1 diabetes, multiple sclerosis and rheumatoid arthritis.
Healio.com, Jan 19, 2015
Conference aims at consensus strategy for developing disease-modifying therapies for children with type 1 diabetes
Researchers, ethicists and regulators attending a consensus conference agree that developing disease-modifying therapies for children with type 1 diabetes may require different clinical trial and approval pathways.
MedlinePlus.com, Dec. 30, 2014
1 in 3 People With Type 1 Diabetes Still Produce Insulin, Study Says
Although it's widely accepted that people with type 1 diabetes produce no insulin, a new study suggests otherwise: Roughly one-third produce the hormone long after they are diagnosed. Residual insulin production can last for more than four decades, researchers reported recently in the journal Diabetes Care. Their findings could help avoid the misdiagnosis of type 1 diabetes as the more common type 2 diabetes and improve treatments for blood sugar control, they suggested. Authors include BRI's Diabetes Program Director Carla Greenbaum, MD, and T1D Exchange Program Manager at BRI Asa David, PhD. See the press release.
MSNNewsChannel.com, Dec. 24, 2014
Researchers Identify Biomarker and Potential Therapy Target in MS
Researchers from Benaroya Research Institute at Virginia Mason (BRI) have found that proteins in the IL-6 signaling pathway may be leveraged as novel biomarkers of multiple sclerosis (MS) to gauge disease activity and as a target for new therapies.
Seattle Business, December 2014
"Immunotherapy research is rebooting Seattle’s biotech sector. It might even save your life."
The potential for immunotherapy to provide a cure extends far beyond cancer. At BRI, scientists are using immunotherapy to target Type 1 diabetes, multiple sclerosis and rheumatoid arthritis.
Northwest Association of Biomedical Research Blog, Nov. 6, 2014
"Our Biotech Future"
In this blog, Ken Gordon, Executive Director of the Northwest Association of Biomedical Research, talks about the importance of research to the Pacific Northwest and the inspiring work that BRI is doing.
Medical Daily, Nov. 3, 2015
"An Exploration Of Food Allergies Reveals The Link Between Inflamed Skin, GI Inflammation, And Food Reactions"
A new study by BRI researcher Steven Ziegler, PhD, suggests proteins in food may be responsible for causing inflamed skin, and so an overall link exists between skin sensitization, gastrointestinal inflammation, and food reactions.
Puget Sound Business Journal, Oct. 13, 2014
“Bid 'achoo' adieu: Virginia Mason lands $2.2M grant to eliminate allergies”
Annie Zak reported Benaroya Research Institute at Virginia Mason received a federal grant from the National Institutes of Health for $2.2 million last week to find a biomarker that triggers allergies.
KUOW Radio, NPR, Oct. 2, 2014
"Is King County More Prepared for Eblola? Officials Say Yes"
BRI researcher Adam Lacy-Hulbert, PhD, is interviewed regarding his research on ebola and infectious diseases. He explains his grant to research the basic mechanisms of how viruses get into cells and what drugs could counter this process.
Puget Sound Business Journal, Aug. 26, 2014
“Grapes on Green brings in record green for Benaroya Research Insitute at Virginia Mason”
Patti Payne wrote: “The wine flowed, a bagpipe wailed and the bright sun left red streaks on the horizon as a crowd of several hundred people gathered for the Virginia Mason Foundation’s annual Grapes on the Green dinner auction at the Golf Club at Newcastle. This year, the popular event brought in a record $555,000 and counting for the Benaroya Research Institute (BRI) at Virginia Mason.”
New Day Northwest, Aug. 14, 2014
The Boeing Classic benefitting autoimmune disease research
BRI researcher, Dan Campbell, PhD, and Lauren Lippincott, who has five autoimmune diseases, discuss the genetic connections between diseases and how research is progressing.
Puget Sound Business Journal, Aug. 13, 2014
MultiCare, Virginia Mason land $4.2 million grant to expand cancer clinical trials
Tacoma’s MultiCare Health System and Virginia Mason in Seattle (BRI's clinical research program) have received a $4.2 million grant to launch the Northwest NCI Community Oncology Research Program to expand cancer treatment trials in Washington, Idaho and Alaska.
Accelerator Corporation, July 29, 2014
Accelerator Corporation Secures $51.1 Million to Support Research
In Seattle, Accelerator has expanded its partners beyond the Institute for Systems Biology to include Benaroya Research Institute at Virginia Mason, Infectious Disease Research Institute (IDRI), Pacific Northwest Diabetes Research Institute, Puget Sound Blood Center Research Institute, Seattle BioMed, Seattle Children's Research Institute and Washington State University. Collectively, these institutions will provide Accelerator companies with unparalleled access to technology development capabilities and scientific expertise.
Puget Sound Business Journal, May 7, 2014
Seattle heavyweights take a shot at allergy research
BRI is a part of the Seattle Food Allergy Consortium (SeaFAC), a newly established network of researchers focused on food allergies. The organization will work to attract food allergy clinical trials, as well as federal and private funding to this region.
Q13 FOX News, Apr. 18, 2014
Health Tips: The true necessity of those who need Gluten free
Elisa Boden, MD, BRI clinical researcher was interviewed about celiac disease for the Q13 FOX Medical Desk at Virginia Mason.
Q13 FOX News, Mar. 10, 2014
Health Tips: Simple warning signs that point to MS
Mariko Kita, MD, BRI clinical researcher was interviewed about multiple sclerosis for the Q13 FOX Medical Desk at Virginia Mason.
Northwest Asian Weekly, Feb. 22-28, 2013
Women Honored for Healthcare Service
Mariko Kita, MD, BRI clinical researcher and director of the Virginia Mason Multiple Sclerosis Center and Sarah Patterson, chief operating officer of Virginia Mason Medical Center, were honored for their healthcare service.
King 5 News, Feb. 19, 2014
A Painless Alternative to Standard Liver Biopsy
Patient Darryl Schmidt and Kris Kowdley, MD, BRI clinical researchers and director, Liver Center of Excellence, were featured in this HealthLink story about fibroscan technology. Virginia Mason is the first in the area to offer the fibroscan.
Biochemist, February 2014
An Ancient Mariner: Biological Implications of the coelacanth genome
Chris Amemiya, PhD, BRI Director of Molecular Genetics, discusses the recent sequencing of the coelacanth genome that has enabled insights into the fin–limb transition and the origin of terrestriality.
425 Magazine, Jan. - Feb. 2014
Science Fridays: Coming together to help fight autoimmune diseases
Margo Greenman explains autoimmune diseases and describes the Science Friday tours at BRI.
Puget Sound Business Journal, Jan. 23, 2014
Benaroya Research Institute wins grant to lead international immune research effort
Valerie Bauman reports on the grant from the National Institutes of Health for BRI to lead the Immune Tolerance Network. BRI Director Gerald Nepom, MD, PhD is interviewed.
Q13 Fox News, Dec. 20, 2013
Artificial Pancreas, with Dr. Greenbaum
Dr. Greenbaum was featured in a Q13 Fox News, Medical Desk segment for a story about the Artifical Pancreas system now being tested at Benaroya Research Institute. For more information about BRI's groudbreaking clinical trial testing the Artifical Pancreas, click here.
A Companion to the Big Picture Science Radio Show
Big Picture Science -- Monster Mashup: Chris Amemiya
Part 2 of Skeptic Check: Monster Mashup featuring Chris Amemiya, PhD, BRI Director of Molecular Genetics, on the discovery of the coelacanth.
The Economist, Intelligent Life Magazine, November/December 2013
A Fish for Our Time
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The story of the coelacanth, an important biological find. The article includes the efforts and success of BRI's Director of Molecular Genetics, Chris Amemiya, PhD, in leading an international team to analyze the genome sequencing of the coelacanth.
New Day Northwest, Aug. 19, 2013
Groundbreaking clinical trial of an artificial pancreas
Nurse practitioner Dana VanBuecken, Diabetes Clinical Research Program at Benaroya Research Institute, and research participant, Annie Shultz discussed their experiences with the artificial pancreas clinical trial. BRI Associate Director Jane Buckner, MD, explained the connection between autoimmune diseases and how BRI is fighting them.
Seattle Health, Spring/Summer 2013
The MS Mystery
Mariko Kita, MD, director, Multiple Sclerosis Clinic, was interviewed and quoted for this article about multiple sclerosis in the Pacific Northwest.
New York Times, April 27, 2013
Fish’s DNA May Explain How Fins Turned to Feet
BRI's Director of Molecular Genetics, Chris Amemiya, PhD, leds an international team to analyze the genome sequencing of the coelacanth.
Multiple Sclerosis Discovery Forum, Feb. 8, 2013
Resisting Arrest: Regulatory T cells outmatched in active disease
Insightful look into the exciting multiple sclerosis findings from BRI's researchers Drs. Jane Buckner and Mariko Kita.
Bloomberg News, Jan. 30, 2013
Rogue Immune Cells Tied to MS Point to New Drug Target
Scientists at Benaroya Research Institute and Virginia Mason identified a protein called interleukin-6, or IL-6, as a reason for those cells going rogue in patients with relapsing-remitting multiple sclerosis, the most common form of the disease. Jane Buckner, MD, associate director, BRI, was quoted.
BioSpace, Jan. 2, 2013
Fluidigm Corporation completes c1™ single-cell auto prep system early access program
BRI's Vivian Gersuk, PhD, comments on this high technology tool that BRI was the first to receive.
Medicon Valley Nordic Life Sciences, November 2012
Copenhagen hosts international symposium on Autoimmune Diseases
Jane Buckner, MD, BRI Associate Director discusses current research in autoimmune diseases.
KUOW 94.9 Puget Sound Public Radio, Nov. 27, 2012
Search For Cause Of High Rates Of MS In Northwest Could Lead To New Treatments
Immunologist Estelle Bettelli, PhD, Benaroya Research Institute, and Mariko Kita, MD, director, Multiple Sclerosis Center, were featured in this story about new treatment strategies for multiple sclerosis.
KING 5 TV, August 22, 2012
Doctors studying ways to prevent Type 1 diabetes
KING 5 TV reported on a diabetes study to prevent Type 1 diabetes and we are participating in this clinical trial. For more information on sites in the Pacific NW please call 1-800-888-4187. For more diabetes research information.
New Day Northwest, Aug. 20, 2012
The Boeing Classic benefits local organizations
BRI researcher Jane Buckner, MD, and her patient, Michelle Munro, who was diagnosed with relapsing polychondritis, discuss BRI's latest research for autoimmune diseases and the difficulties in living with these conditions.
Seattle Times, July 23, 2012
Immune-system transplant approved; new hope for Crohn's patients
Researchers at the Fred Hutchinson Cancer Research Center were approved to begin a trial to test whether a bone-marrow transplant from a healthy donor can cure patients with severe Crohn's disease by giving them a new immune system. The Crohn's Allogeneic Transplant Study's investigation team also includes the University of Washington, Seattle Children's and the Benaroya Research Institute.
Puget Sound Business Journal, July 2, 2012
Benaroya Research Institute promotes Homer Lane Jr. to executive director
Benaroya Research Institute at Virginia Mason (BRI) has named Homer Lane Jr. as executive director. He has also been named vice president for research at Virginia Mason Medical Center, in Seattle. Both appointments were effective July 1.
Puget Sound Business Journal, June 28, 2012
Virginia Mason's Benaroya Research Institute partners with Novo Nordisk
Benaroya Research Institute at Virginia Mason is partnering with Novo Nordisk for a three-year collaboration to accelerate the research process for diagnosis and treatment of rheumatoid arthritis, inflammatory bowel disease and lupus.
Nature, May 17, 2012
Perspective: Rethink the immune connection
Carla Greenbaum, MD, director of the Diabetes Research Program at Benaroya Research Institute, authored this article about Type 1 diabetes and the immune system.
Puget Sound Business Journal, May 14, 2012
Jack Benaroya public remembrance fills Seattle's Benaroya Hall
Gerald Nepom, MD, PhD, director, Benaroya Research Institute at Virginia Mason, was quoted about Jack Benaroya's medical philanthropy in the area of diabetes.
Puget Sound Business Journal, May 11, 2012
Real estate developer, philanthropist Jack Benaroya has died
Jack Benaroya supported BRI and made an impact on medical research.
The Seattle Times, May 11, 2012
Philanthropist and developer Jack Benaroya has died
Mr. Benaroya provided great support to Benaroya Research Institute at Virginia Mason.
Journal Science, May 4, 2012
Western U.S. Bioclusters: The Pioneer Spirit
Benaroya Research Institute is highlighted as an autoimmune diseases research center as part of the Seattle biocluster epicenter.
Northwest Cable News, Nov. 14, 2011
Diabetes Awareness Day (link is no longer valid)
Carla Greenbaum, MD, BRI Diabetes Research Program Director is interviewed about the prevalence of diabetes, the need for research and awareness efforts through Diabetes Awareness Day.
KING5.Com Your News, Nov. 14, 2011
Shining a Light on Diabetes Awareness
Benaroya Research Institute and BRI Diabetes Research Program Director, Carla Greenbaum, MD, participated in Diabetes Awareness Day.
KIRO 7 News, Nov. 4, 2011
Illuminations Luncheon and Autoimmune Diseases Research
News anchor Steve Raible emceed the Illuminations Luncheon fundraising event for Benaroya Research Institute and reported about it during the evening news broadcast.
KING 5 New Day Northwest, August 22, 2011
Boeing Classic and Benaroya Research Institute
BRI Clinical Researcher, James Lord, MD, PhD, and research participant Angelina Clarke discuss Crohn's disease and the latest autoimmune disease research at BRI.
O’Reilly Radar, July 29, 2011
Report from Open Source convention health track, 2011
Andy Oram comments on an open source convention he attended. He includes information about a talk given by Charlie Quinn, director, Data Integration Technologies at Benaroya Research Institute.
The Seattle PI, July 23, 2011
Seafair Triathlon Photos
Photos taken at the Benaroya Research Institute Triathlon at Seafair
Auburn Report, November 24, 2010
Auburn Mountainview to Host Benaroya Resarch Institute Type 1 Diabetes Screening
Auburn Reporter featured a story about Auburn Mountainview High School hosting Benaroya Research Institute for a free Type 1 diabetes TrialNet screening for school district families on Nov. 30.
Puget Sound Business Journal, September 3-9, 2010
Where syrah meets sand traps -- Grapes on the Green fundraiser collects $265K for scholarships and research
Puget Sound Business Journal reports on fundraiser for Benaroya Research Institute.
Puget Sound Business Journal, September 7, 2010
Benaroya Research Institute Gets $11.7M grant
Puget Sound Business Journal announced Benaroya Research Institute received an $11.7 million federal grant to research lung inflammatory diseases.
A Sweet Life, September 2, 2010
On the Trail of Autoimmunity: Dr. Jane Buckner
A SweetLife, a Web site about healthy living with diabetes, posted an article about Jane Buckner, MD, associate member, Benaroya Research Institute.
Puget Sound Business Journal, August 31, 2010
Benaroya Research Institute gets $2.2M grant
Puget Sound Business Journal announced Benaroya Research Institute received a $2.2 million federal grant to study autoimmune diseases.
King 5 New Day Northwest, August 25, 2010
Ongoing research helps to understand MS
New Day Northwest on KING TV featured BRI Clinical Investigator and VM neurologist Mariko Kita, MD, and patient Tracey Barnes discussing multiple sclerosis.
King 5 New Day Northwest, August 18, 2010
New developments for diabetes patients
New Day Northwest on KING TV featured Benaroya Research Institute Director of Diabetes Clinical Research Carla Greenbaum, MD, and the Porcara family, research participants, discussing diabetes research.
King 5 New Day Northwest, August 11, 2010
New advances for some rheumatic diseases
New Day Northwest featured BRI Clinical Investigator Stanford Peng, MD, PhD, who is also a rheumatologist at Virginia Mason Medical Center, and Jeffrey Carlin, MD, VM rheumatologist, along with patient Linda Sloate discussing rheumatic diseases and research.
The Seattle Times, July 28, 2010
At-risk groups urged to get tested for hepatitis B
In an effort to better understand hepatitis B, a nationwide clinical research trial is under way. Benaroya Research Institute is a part of this important network. Kris Kowdley, MD, BRI Clinical Investigator and Director of the Center for Liver Disease at Virginia Mason, and patient Ryan Tran are quoted.
The SnoValley Star, July 9, 2010
Seattle native Fred Couples will play in 2010 Boeing Classic
Seattle native Fred Couples will participate in the Boeing Classic this year. Benaroya Research Institute at Virginia Mason is the beneficiary of the event.
Puget Sound Business Journal, January 22, 2010
Boeing Classic golf event changes charity beneficiary
Officials at the Boeing Classic golf event, set for Aug.23-29 at the TPC Snoqualmie Ridge golf course in Snoqualmie, said the event's new charity beneficiary will be the Benaroya Research Institute at Virginia Mason.
KING 5 News, April 8, 2009
Painting for cancer
His mother was diagnosed with cancer. Now, a local painter is using his skills to help search for a cure. KING 5's Eric Wilkinson has the story.
KING 5 News, August 16, 2008
Tacoma athletes promote diabetes awareness
Four Tacoma teens are proving that diabetes doesn't have to stop you from becoming an athlete. They want to motivate other kids with the disease, while they help researchers find a cure.
Seattle Post-Intelligencer, July 21, 2008
Pair of blind triathletes share dedication to research cause
Even blind, Barb Oswald knows a good cause when she finds one. Ditto John Upthegrove. Both took part in Seafair Sunday's Benaroya Research Institute Triathlon.
Diabetes Forecast, American Diabetes Association, June 2008
When Good T-Cells Go Bad
Every once in a while, the systems that protect us from infection and disease go wrong. When that happens, they can mistake the insulin-producing cells in the pancreas for something else entirely and attack--ravaging those cells and preventing them from producing the insulin the body needs. The result is Type 1 diabetes. With a grant from the American Diabetes Association, William Kwok, PhD, an immunologist based at the Benaroya Research Institute at Seattle's Virginia Mason Hospital and Medical Center, is leading a lab full of researchers in a search for the causes of this potentially deadly mix-up.
Medical News Today, June 3, 2008
Leading Immunologists Convene in Boston
Over a thousand scientists and clinicians will convene to present new advances in understanding and treating immune-mediated diseases at FOCIS 2008, the 8th annual meeting of the Federation of Clinical Immunology Societies (FOCIS), June 5-9 at the Boston Marriott Copley Place. Jerry Nepom, MD, PhD, Director of the Benaroya Research Institute at Virginia Mason, is president of FOCIS.
Seattle Post-Intelligencer, April 26, 2008
Researchers eye new weapon in allergy war
Using a $5.3 million grant from the National Institutes of Allergy and Infectious Disease, Dr. William Kwok of BRI and Dr. David Robinson of the Virginia Mason Asthma and Allergy Clinic are studying cells from people allergic to such things as cat dander, tree and grass pollen, peanuts and mold.
Puget Sound Business Journal, April 18, 2008
Life Sciences Discovery Fund Allots $22M in grants
Five Washington Health research organizations have received $22 million in funding from the sate's Life Sciences Discovery Fund.
Seattle Post-Intelligencer, April 17, 2008
State awards $22 million in life sciences grants
A state fund tasked with distributing $350 million in tobacco settlement money to support life sciences research in Washington made its first official outlay Thursday afternoon, distributing $22 million in grants among five programs.
Puget Sound Business Journal, February 18, 2008:
Benaroya Research Institute gets $5.3M grant to study allergies
The grant from the National Institutes of Allergy and Infectious Diseases will be given to William Kwok and Dr. David Robinson of the Virginia Mason Asthma and Allergy Clinic.
Puget Sound Business Journal, December 3, 2007:
$9.4M goes to Benaroya for autoimmune work
The Benaroya Research Institute at Virginia Mason Medical Center has landed another multimillion-dollar grant, this one for $9.4 million, as it continues to focus research and clinical trials on solving the riddle of autoimmune diseases.
Puget Sound Business Journal, October 22, 2007:
Seattle's Benaroya Research Institute, known for its work on diabetes and autoimmune disorders, is taking on a new field of science: battlefield medicine.
Seattle Woman, October, 2007:
Investigating Autoimmune Disease
Jane Buckner, MD, Research Director at Benaroya Research Institute at Virginia Mason, was interviewed on autoimmune research in an article titled "Investigating why women are more prone to autoimmune diseases" in the October issue of the magazine.
Seattle Post Intelligencer, June 7, 2007:
Seattle at forefront for Type 1 diabetes research
Rates here are growing -- and no one knows why.
KING 5 News, May 14, 2007:
Cancer drug might help stop Type 1 diabetes
Twelve-year-old Rylan Martin is testing a cancer drug called rituximab. It's approved to treat lymphoma and rheumatoid arthritis, but Rylan doesn't have either one.
Seattle Post Intelligencer, May 1, 2007:
Diabetes cases double in county
'We need to understand why people aren't listening,' study's author says.
Seattle Post Intelligencer, March 22, 2007:
Cure for juvenile diabetes faces a big hurdle
Seattle and Sweden share a perch on one "top 10" ladder that people in both places would rather descend than climb -- high incidences of Type 1 (juvenile) diabetes.
KING 5 News, March 10, 2007:
Seattle study looks at Type one diabetes
A multinational study is being launched locally at the Benaroya Research Institute. The goal of the study is to identify people who are at risk of developing Type 1 diabetes, and see if we can prevent them, or delay the onset of their disease.
KING 5 News, March 3, 2007:
Seattle researchers tackle juvenile diabetes
There's new hope in the battle against Type 1 diabetes, the form that attacks young children. Now local researchers are taking a step closer to defeating the disease.
Seattle Post Intelligencer, July 17, 2006:
Records set in Seafair triathlon
Seattle's Dave Messenheimer and Steilacoom's Heidi Grimm captured the men's and women's overall titles in the sixth annual Benaroya Research Institute Triathlon at Seafair on Sunday at Seward Park.
Seattle Post Intelligencer, July 15, 2006:
Seafair triathlon's popularity soaring
Mark Davies has competed in dozens of triathlon since 1996. He's been an Iron Man competitor in Brazil, New Zealand, Canada and across the United States. But there's something about the Benaroya Research Institute Triathlon at Seafair that makes the event one of his all-time favorites.
Seattle Post Intelligencer, July 5, 2006:
Seattle in demand on even a molecular level
Thanks to Dr. Jerry Nepom and his gang of scientists at a research facility few people might know by name, Seattle provides much of the world with a spiderlike molecule that has become one of the research community's hottest new tools.
KING5 News, May 20, 2006:
New drug combination could help juvenile diabetics
Kids with Type 1 diabetes face major health complications as they age and the disease continues to damage their bodies. Now some Seattle researchers are working to buy them crucial time.
KOMO News, November 14, 2005:
That Old Justin Timberlake Record Could Help Save A Life
It's a medical breakthrough, and it's happening at Seattle's Benaroya Research Institute. But researchers are scratching the surface, and finding their groove through an unlikely means.
Seattle Post-Intelligencer, November 2, 2004:
Anthrax vaccine to be studied in Seattle
Benaroya Research Institute was awarded one of 14 grants in a $74 million program launched by the National Institute of Allergy and Infectious Diseases.
Puget Sound Business Journal, March 12, 2004:
Community must emulate R&D institutions
Gerald T. Nepom, director of Benaroya Research Institute at Virginia Mason, outlines a path toward scientific discovery based on a partnership between scientists and the community.
Puget Sound Business Journal, March 12, 2004:
R&D community finds strength in numbers
Seattle research organizations, including Benaroya Research Institute at Virginia Mason and The Hope Heart Institute, work together to fuel collaborative advancements in disease research.
Puget Sound Business Journal, November 28, 2003
$250 million eyed to grow biotech here
Commissioned by Governor Locke, a committee of government and industry experts is to submit a proposal that would bring $250 million in state funding to the local biotech scene. Initiative Bio 21 aims to boost the state economy and position Washington to compete with other regions vying for biotech growth by funding collaborative research in diagnostics and therapeutics, bioengineering and health-care informatics.
Seattle Post-Intelligencer, June 16, 2003:
Seattle Lab Designing Key to Unlock Genetic Secrets
The human genome project has given rise to a new kind of science in which animal genomes are compiled for use as tools to understand human genetic code.
EDC Economic Forecast, January 2003:
Vibrant Biomedical Landscape Lays Solid Foundation
The Economic Development Council Economic Forecast sponsored by the Puget Sound Business Journal featured an editorial by Dr. Gerald Nepom on the social and economic issues facing the changing face of human health services