Benaroya Research Institute (BRI) is on a mission to predict, prevent, reverse and cure immune system diseases. We study the cells and processes within the immune system, how and why immune system diseases start, and how to rebalance the immune system back to health. Our focus spans a wide variety of immune system diseases – including autoimmune diseases, asthma, allergy and cancer – with the goal of transforming our understanding of how to prevent and treat these conditions.
Collaboration defines our work. We build teams within our institute and with partners around the world to take on some of the most difficult questions in immunology. This approach moves us closer to our vision of a healthy immune system for everyone.
Our Centers of Discovery: A pipeline from lab research to life-changing care
BRI’s research is organized around four Centers of Discovery, allowing us to accelerate advances at every stage of our work. Our centers enable us to make discoveries in the lab and provide a foundation for new and innovative therapies. They also help us to take questions directly from the clinic — such as what makes a therapy work for one person and not another — back to our labs to find meaningful answers.
Our Biorepositories
BRI is home to 11 biorepositories with thousands of blood and tissue samples that have been donated to science, spanning 20 different immune system diseases as well as healthy controls. Access to human samples allows us to closely study diseases in the lab, make new insights, and bring those insights to patient care faster.
Our Core Labs: Building and using the latest tools and technologies
Our Core Labs enable our scientists to build and use some of the most innovative tools in immunology that allow for advanced imaging, data sequencing and exploring the human genome. Each core is led by an expert in their field. Scientists across BRI and from other institutes can partner with these experts to leverage these tools and fuel discoveries in all areas of research.
Our Team: Together we discover
Collaboration is one of BRI’s core values, and our team is our biggest asset. We have built our organization to facilitate teamwork across disease areas, with experts working across fields and with partners around the globe. Shared resources like our Core Labs, Clinical Research Center and biorepositories fuel discoveries across our institute.
Featured Publications
Aug 2025
cytoKernel: robust kernel embeddings for assessing differential expression of single-cell data
Bioinformatics
Tusharkanti Ghosh, Ryan M Baxter, Souvik Seal, Victor G Lui, Pratyaydipta Rudra, Thao Vu, Elena W Y Hsieh, Debashis Ghosh
Aug 2025
Single-cell transcriptomic profiling of eosinophils and airway immune cells in childhood asthma
J Allergy Clin Immunol
Naresh Doni Jayavelu, Andrew H Liu , Courtney Gaberino, Kristy Freeman, Matthew Lawrance, Stephan Pribitzer, Clara Seifert, Cullen Dutmer, Alkis Togias, Patrice M Becker, William W Busse, Christine A Sorkness, Carmen Mikacenic, Kimberly A Dill-McFarland, Daniel J Jackson, Matthew C Altman
Aug 2025
Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study
Front Med (Lausanne)
Jintong Hou, Benjamin Haslund-Gourley, Joann Diray-Arce, Annmarie Hoch, Nadine Rouphael, Patrice M Becker, Alison D Augustine , Al Ozonoff, Leying Guan, Steven H Kleinstein, Bjoern Peters, Elaine Reed, Matt Altman, Charles R Langelier, Holden Maecker, Seunghee Kim, Ruth R Montgomery, Florian Krammer, Michael Wilson, Walter Eckalbar, Steven E Bosinger, Ofer Levy, Hanno Steen, Lindsey B Rosen, Lindsey R Baden, Esther Melamed, Lauren I R Ehrlich, Grace A McComsey, Rafick P Sekaly, Joanna Schaenman, Albert C Shaw, David A Hafler, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough , William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Monica Kraft, Chris Bime, Carolyn S Calfee, David J Erle, IMPACC Network, Lucy F Robinson, Charles B Cairns, Elias K Haddad, Mary Ann Comunale
Aug 2025
Contrasting Adult and Pediatric Populations in a Cohort of At-Risk Relatives in The T1D TrialNet Pathway to Prevention Study
Diabetes Care
Erin L Templeman, Lauric A Ferrat, Nicholas Thomas, Cate Speake, Diane K Wherrett, Jennifer Sherr, John M Wentworth, Maria J Redondo, Hemang M Parik , Jamie L Felton, Carmella Evans-Molina, Jay Sosenko, Lu You, Richard A Oram, Emily K Sims
Aug 2025
Cockroach immunotherapy modulates dominant T cell responses independent of allergen extract content
J Allergy Clin Immunol
Ricardo da Silva Antunes, Aaron Sutherland, Adam Abawi , April Frazier, Anna Pomés, Jill Glesner, Jay E Slater, Samuel T Mindaye, Kate Cho, Grace Zhou, Marie V Ozanne, Agustin Calatroni, Cynthia M Visness, Matthew C Altman, Robert A Wood, George T O'Connor, Jacqueline A Pongracic, Gurjit K Khurana Hershey, Carolyn M Kercsmar, Rebecca S Gruchalla, Michelle Gill, Daniel Searing, Andrew H Liu , Edward Zoratti, Meyer Kattan , Will Sheehan, Leonard B Bacharier, Stephen J Teach, Lisa M Wheatley , Alkis Togias, William W Busse, Daniel J Jackson, Alessandro Sette
