Available Technology
Variable Lymphocyte Receptors – Lamprey
Tech Summary
The researchers at Benaroya Research Institute and University of Alabama at Birmingham have identified and isolated a panel of highly variable lymphocyte receptors in Lamprey, Petromyzon marinus. The panel is derived from functional receptors involved in adaptive immune response within Lamprey. These receptors are generated through somatic rearrangement resulting in diverse set of receptors, each with unique antigen specificities. These receptors are able to selectively bind various virus, bacterium, parasite, fungus, and toxins.
Petromyzon marinus, commonly known as sea lamprey, is a jawless vertebrate. It is the first non-jawed vertebrate identified to have an adaptive immune system with variable immune receptors analogous to T-lymphocyte receptors found in jawed vertebrates.
DNA sequences and corresponding amino acid sequences for a panel of variable lymphocyte receptors of lamprey are available.
The University of Alabama at Birmingham and Benaroya Research Institute has issued patents in the United States and Australia, and pending patent applications in several jurisdictions worldwide.
Featured Publications
Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes.
Commun Biol
Proinflammatory islet antigen reactive CD4 T cells are linked with response to alefacept in type 1 diabetes.
JCI Insight
The Beta Cell-Immune Cell Interface in Type 1 Diabetes (T1D).
Mol Metab
Molecular pathways underlying lung-brain axis signaling in asthma: relevance for psychopathology and neuroinflammation.
J Allergy Clin Immunol
Hydroxychloroquine in Stage 1 Type 1 Diabetes.
Diabetes Care
Contact us
Fill out this form to obtain more information about how you or your institution can utilize BRI's technologies for your own research.
