Lynda Stuart, MD, PhD
Background Information
Dr Lynda Stuart earned an MD from the University of Cambridge and the University of London and a PhD in Immunology from the University of Edinburgh. She completed residency training in Internal Medicine in the United Kingdom and postdoctoral training at Harvard Medical School. For eight years, Lynda was a member of the faculty at the Massachusetts General Hospital and Harvard Medical School where she was co-director of the Laboratory of Developmental Immunology; a member of the Center for Computational and Integrative Biology, an affiliate of the Broad Institute of Harvard and MIT; and served on the Massachusetts General Hospital Executive Committee for Research. In 2013, she joined the Bill and Melinda Gates Foundation, where she leads the team that aims to source novel approaches and accelerate the discovery, development, and translation of new passive and active immunization strategies for foundation priority diseases.
Area of Research
Dr Stuart remains actively involved in basic research in collaboration with Dr Lacy-Hulbert. Her main research interests are in discovering fundamental mechanisms of innate and adaptive immunity to infection, the role of phagocytosis in the immune system, and immune regulation.
Featured Publications
Bruchez A, Sha K, Johnson J, Chen L, Stefani C, McConnell H, Gaucherand L, Prins R, Matreyek KA, Hume AJ, Mühlberger E, Schmidt EV, Olinger GO, Stuart LM and Lacy-Hulbert A (2020) “MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like Coronaviruses.” Science in press
Karp CL, Wilson CB, Stuart LM. (2015) “Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool.” Immunol Rev. 2015 Mar;264(1):363-81.
Sokolovska A, Becker CE, Ip WK, Rathinam VA, Brudner M, Paquette N, Tanne A, Vanaja SK, Moore KJ, Fitzgerald KA, Lacy-Hulbert A and Stuart LM. (2013) “Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.” Nat. Immunol 14: 543-53.
Boyer L, Magoc L, Dejardin S, Cappillino M, Paquette N, Hinault C, Charriere GM, Ip WK, Fracchia S, Hennessy E, Erturk-Hasdemir D, Reichhart JM, Silverman N, Lacy-Hulbert A, and Stuart LM (2011) "Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway." Immunity. 35:536-549. PMCID: PMC3258503.
Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA, Lacy-Hulbert A, El Khoury J, Golenbock DT, Moore KJ. (2010) “CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.” Nat Immunol. 11(2):155-161.
Stuart LM, Boulais J, Charriere GM, Hennessy EJ, Brunet S, Jutras I, Goyette G, Rondeau C, Letarte S, Huang H, Ye P, Morales F, Kocks C, Bader JS, Desjardins M, Ezekowitz RA. “A systems biology analysis of the Drosophila phagosome. “Nature. 2007;445(7123):95-101.
Kocks C, Cho JH, Nehme N, Ulvila J, Pearson AM, Meister M, Strom C, Conto SL, Hetru C, Stuart LM, Stehle T, Hoffmann JA, Reichhart JM, Ferrandon D, Rämet M, Ezekowitz RA. (2005) “Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila” Cell. 2005 Oct 21;123(2):335-46.