Flavio Rocha, MD
Dr. Rocha is a staff surgeon at Virginia Mason Medical Center. He also holds appointments as a Clinical Assistant Professor of Surgery at the University of Washington and an Affiliate Investigator at BRI. He attended the Pritzker School of Medicine at the University of Chicago followed by general surgery residency at the Brigham and Women’s Hospital and a postdoctoral research fellowship in tissue engineering at Harvard Medical School. After residency, he completed a surgical oncology and hepatopancreatobiliary surgery fellowship at Memorial Sloan-Kettering Cancer Center. His clinical practice involves all aspects of benign and malignant disease of the liver, bile ducts and pancreas. Dr. Rocha serves as the Director of Research for the Digestive Disease Institute. He is a member of several cancer cooperative groups including the Alliance for Clinical Trials in Oncology and the Eastern Cooperative Group and serves on the Pancreas Task Force at the National Cancer Institute.
Area of Research
Dr. Rocha's research focuses on clinical and translational studies in pancreaticobiliary cancer. This includes biomarker discovery and validation in cholangiocarcinoma and outcomes research following chemotherapy and surgical resection of pancreas cancer. He also performs health services research using large population-based repositories such as the National Cancer Database. Lastly, he serves as a co-investigator for several clinical trials in hepatopancreatobiliary cancers and the PI for the BRITE Tumor Registry.
Laughlin R, Musch M, Holbrook C, Rocha F, Chang E, Alverdy J. The key role of PA-I lectin of Pseudomonas aeruginosa in gut-derived sepsis. Annals of Surgery 2000;232(1),133-142.
Alverdy J, Holbrook C, Rocha F, Seiden L, Wu R, Musch M, Chang E, Ohman D, Suh S, Garber N. Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: Evidence of in vivo expression of PA-I lectin in Pseudomonas aeruginosa. Annals of Surgery 2000;232(4),480-9.
Rocha F, Musch M, Lishanskiy L, Bookstein C, Yue X, Sugi K, Chang E. IFN-g downregulates expression of Na+/H+ exchangers NHE2 and NHE3 in rat intestine and human Caco2/bbe cells. American Journal of Physiology: Cell Physiology 2001;280,C1224-C1232.
Rocha F, Laughlin R, Musch M, Hendrickson B, Chang E, Alverdy J. Surgical stress induces a more adherent phenotype of intestinal Eschericia coli: Role in barrier regulation. Surgery 2001;130(1),65-73.
Lucioni A, Womack C, Musch M, Rocha F, Bookstein C, Chang E. Metabolic acidosis in rats increases intestinal NHE2 and NHE3 expression and function. American Journal of Physiology: Gastrointestinal and Liver Physiology 2002;283:G51-G56.
Musch M, Bookstein C, Rocha F, Lucioni A, Ren H, Daniel J, Yue X, McSwine R, Rao M, Alverdy J, Chang E. Region-specific adaptation of apical Na-H exchangers following extensive proximal small bowel resection. American Journal of Physiology: Gastrointestinal and Liver Physiology 2002;283:G975-85.
Wu L, Holbrook C, Zaborina O, Ploplys E, Rocha F, Pelham D, Chang E, Musch M, Alverdy J. Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelial cell contact and molecules of the quorum sensing signaling system. Annals of Surgery 2003;238:754-64.
Duxbury M, Grikscheit T, Gardner-Thorpe J, Rocha F, Ito H, Perez A, Ashley S, Vacanti J, Whang E. Lymphangiogenesis in tissue-engineered small intestine. Transplantation 2004;77(8):1162-1166.
Rocha F, Shen K, Jasleen J, Tavakkolizadeh A, Zinner M, Whang E, Ashley S. Glucagon-like peptide-2: Divergent signaling pathways. Journal of Surgical Research 2004;121(1):5-12.
Arvans D, Vavricka S, Ren H, Musch M, Kang L, Rocha F, Lucioni A, Turner J, Alverdy J, Chang E. Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins, Hsp 25 and Hsp 72. American Journal of Physiology: Gastrointestinal and Liver Physiology 2005;288(4):G696-704.
Perez A, Duxbury M, Rocha F, Ramsanahie A, Farivar R, Varnholt H, Ito H, Wong H, Rounds J, Zinner M, Whang E, Ashley S. Glucagon-like peptide 2 is an endogenous mediator of post-resection intestinal adaptation. Journal of Parenteral and Enteral Nutrition 2005;29(2);97-101.
Matros E, Rocha F, Wang J, Zinner M, Ashley S, Breen E, Soybel D, Shoji B, Burgess A, Bleday R, Kuntz R, Whang E. Does gum chewing ameliorate postoperative ileus? Results of a prospective, randomized, placebo-controlled trial. Journal of the American College of Surgeons 2006;202(5):773-778.
Berzin T, Rocha F, Whang E, Mortele K, Ashley S, Banks P. Prevalence of primary fungal infections in necrotizing pancreatitis. Pancreatology 2007;7:63-6.
Rocha F, Sundback C, Krebs N, Leach J, Mooney D, Ashley S, Vacanti J, Whang E. The effect of sustained delivery of vascular endothelial growth factor on angiogenesis in tissue-engineered intestine. Biomaterials 2008;29(19):2884-90.
Liau S, Rocha F, Matros E, Redston M, Whang E. High mobility group AT- hook 1 (HMGA1) promotes anchorage-independent growth and is an independent prognostic factor in pancreatic adenocarcinoma. Cancer 2008;113:302-14.
Rocha F, Benoit E, Zinner M, Whang E, Banks P, Ashley S, Mortele K. Impact of radiologic intervention on mortality in necrotizing pancreatitis: The role of organ failure. Archives of Surgery 2009;144(3):261-5.
Rocha F, Theman T, Matros E, Ledbetter S, Zinner M, Ferzoco S. Nonoperative management of patients with a computed tomography diagnosis of high-grade small bowel obstruction. Archives of Surgery 2009;144(11):1000-4.
Rocha F, Matsuo K, Blumgart L, Jarnagin W. Hilar cholangiocarcinoma: The Memorial Sloan-Kettering Cancer Center experience. Journal of Hepatobiliary and Pancreatic Sciences 2010;17:490-6.
Kingham T, Tanoue M, Eaton A, Rocha F, Do R, Allen P, DeMatteo R, D’Angelica M, Fong Y, Jarnagin W. Patterns of recurrence after ablation of colorectal liver metastases. Annals of Surgical Oncology 2012;19:834-41.
Matsuo K, Rocha F, Ito K, D’Angelica M, Allen P, Fong Y, DeMatteo R, Gonen M, Endo I, Blumgart L, Jarnagin W. The Blumgart preoperative staging system for hilar cholangiocarcinoma: Analysis of resectability and outcome in 380 patients. Journal of the American College of Surgeons 2012;215:343-55.
Winter J, Tang L, Klimstra D, Brennan M, Rocha F, Jia R, Qin L, D’Angelica M, DeMatteo R, Fong Y, Jarnagin W, O’Reilly E, Allen P. MUC1 and mesothelin distinguish long and short-term survival in pancreatic ductal adenocarcinoma. PloS ONE 2012;7(7):e40157.
Rocha F, Lee H, Katabi N, DeMatteo R, Fong Y, D’Angelica M, Allen P, Klimstra D, Jarnagin W. Intraductal papillary neoplasm of the bile duct (IPNB): A biliary equivalent to IPMN of the pancreas? Hepatology 2012;56:1352-60.
LaFemina J, Chou J, Gönen M, Rocha F, Correa-Gallego C, KinghamT, DeMatteo R, Fong Y, D’Angelica M, Jarnagin W, Allen P. Hepatic arterial nodal metastases in pancreatic cancer: Is this the node of importance? Journal of Gastrointestinal Surgery 2013;17(6):1092-7.
Bickenbach K, Karanicolas PJ, Ammori JB, Jayaraman S, Winter J, Fields RC, Govindarajan A, Nir I, Rocha F, Brennan MF. Up and down or side to side? A systematic review and meta-analysis examining the impact of incision on outcomes following abdominal surgery. American Journal of Surgery 2013;206(3):400-9.
Ross AS, Irani S, Gan SI, Rocha F, Siegal J, Fotoohi M, Hauptmann E, Robinson D, Crane R, Kozarek R, Gluck M. Dual-modality drainage of infected and symptomatic walled-off pancreatic necrosis: long-term clinical outcomes. Gastrointestinal Endoscopy 2014;79(6):929-35.
Rocha F, Boughey JC and Nelson H. Less invasive option for small hepatocellular carcinoma: Thermal ablation as first-line therapy? Bulletin of the American College of Surgeons 2014;99(2):46-8.
Rose JB, Rocha F, Alseidi A, Biehl T, Moonka R, Ryan J, Lin B, Picozzi V, Helton S. Extended neoadjuvant chemotherapy for borderline resectable pancreatic cancer demonstrates promising postoperative outcomes and survival. Annals of Surgical Oncology 2014;21(5):1530-7.
Reynolds P, Willingham F, Lewis M, Ross A, Maithel S, Rocha F. Hybrid push-pull endoscopic and laparoscopic full thickness resection for the minimally invasive management of gastrointestinal stromal tumors (GIST). Gastroenterology Research and Practice 2015 pp618756.
Rocha F, Hashimoto Y, Traverso W, Dorer R, Kozarek R, Helton S, Picozzi V. Interferon-based chemoradiation for resected pancreatic head cancer: Long-term results of the Virginia Mason protocol. Annals of Surgery 2016;263(2):376-84.
Perini M, Coelho F, Kruger J, Rocha F, Herman P. Extended right hepatectomy with caudate lobe using the hilar “en bloc” resection technique with a modified hanging maneuver. Journal of Surgical Oncology 2016;113(4):427-31
Rose J, Correa-Gallego C, Li Y, Nelson J, Alseidi A, Helton S, Allen P, D’Angelica M, DeMatteo R, Fong Y, Kingham T, Kowdley K, Jarnagin W, Rocha F. The role of biliary carcinoembryonic antigen-related cellular adhesion molecule 6 (CEACAM6) as a biomarker in cholangiocarcinoma. PLoS One 2016;11(3):e0150195
Crown A, Biehl T, Rocha F. Local resection for duodenal gastrointestinal tumors. American Journal of Surgery 2016;211(5):867-70
Jutric Z, Johnston WC, Grendar J, Haykin L, Mathews C, Harmon LK, Shen J, Hahn HP, Coy DL, Cassera MA, Helton WS, Rocha F, Wolf RF, Hansen PD, Hammill CW, Alseidi AA, Newell PH. Preoperative computed tomography scan to predict pancreatic fistula after distal pancreatectomy using gland and tumor characteristics. American Journal of Surgery 2016;211(5):871-6
Rocha F, Boughey JC. Studies address metabolic image-directed oncologic therapy for gastric cancer Bulletin of the American College of Surgeons 2016;101(5):48-50
Alemi F, Rocha F, Helton S, Biehl T, Alseidi A. Mesenteric venous reconstruction classification and techniques for hepatopancreatobiliary cancers. HPB 2016;18(10):827-34.
Oh S, Edwards A, Mandelson M, Hahn H, Alseidi A, Biehl T, Rocha F, Helton S, Picozzi V. Localized pancreatic cancer with positive peritoneal cytology as a sole manifestation of metastatic disease: A single institution experience. American Journal of Surgery 2017;213(1):94-99.
Bertens K, Crown A, Clanton J, Alemi F, Alseidi A, Biehl T, Helton S, Rocha F. What is a better predictor of clinically relevant pancreatic fistula (CRPF) following pancreaticoduodenectomy (PD): Postoperative day one drain amylase (POD1DA) or the fistula risk score (FRS)? HPB 2017;19(1):75-81.