Scott Presnell, PhD
Dr. Presnell received his B.S. degree in Chemistry from Stanford University, Palo Alto CA in 1983, and his PhD in Chemistry from Harvard University, Cambridge MA, in 1988. Dr. Presnell worked as a Bioinformatics Scientist and Scientific Computing Director for ZymoGenetics, Inc in Seattle WA from 1993 to 2011. He joined Benaroya Research Institute in 2011 as a Bioinformaticist, and subsequently became an Associate Member and Bioinformatics Core Manager in 2014.
Area of Research
Dr. Presnell is pursuing research in data structures that support the heterogeneous nature of experiments in systems immunology research and novel visualizations for presenting the results from these experiments. Dr. Presnell is also interested in statistical methods as applied to systems immunology, machine learning applied to biochemical and biostructure problems, and high performance computing in support of bioinformatics analysis.
The Bioinformatics Core is focused on enabling discovery in autoimmunity through excellence in bioinformatics. The group provides comprehensive experimental design, analysis and visualization for BRI research scientists. The Bioinformatics Core has access to a high performance computing infrastructure and specialized software to support processing, analyzing and visualizing data from heterogeneous sources and is actively engaged in developing and applying sophisticated analytical methods for biomarker identification and validation, and the elucidation of mechanisms of autoimmune diseases.
Obermoser G, Presnell S, Domico K, Xu H, Wang Y, Anguiano E, Thompson-Snipes L, Ranganathan R, Zeitner B, Bjork A, Anderson D, Speake C, Ruchaud E, Skinner J, Alsina L, Sharma M, Dutartre H, Cepika A, Israelsson E, Nguyen P, Nguyen QA, Harrod AC, Zurawski SM, Pascual V, Ueno H, Nepom GT, Quinn C, Blankenship D, Palucka K, Banchereau J, Chaussabel D. Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines. Immunity. 2013 Apr 18;38(4):831-44. PubMed PMID: 23601689, PMCID: PMC3681204.
Chiche L, Jourde-Chiche N, Whalen E, Presnell S, Gersuk V, Dang K, Anguiano E, Quinn C, Burtey S, Berland Y, Kaplanski G, Harle JR, Pascual V, Chaussabel D. Modular Transcriptional Repertoire Analyses of Adults With Systemic Lupus Erythematosus Reveal Distinct Type I and Type II Interferon Signatures. Arthritis Rheumatol. 2014 Jun;66(6):1583-95. PubMed PMID: 24644022.
Li S, Rouphael N, Duraisingham S, Romero-Steiner S, Presnell S, Davis C, Schmidt DS, Johnson SE, Milton A, Rajam G, Kasturi S, Carlone GM, Quinn C, Chaussabel D, Palucka AK, Mulligan MJ, Ahmed R, Stephens DS, Nakaya HI, Pulendran B. Molecular signatures of antibody responses derived from a systems biology study of five human vaccines. Nat Immunol. 2014 Feb;15(2):195-204. PubMed PMID: 24336226, PMCID: PMC3946932.
Speake C, Presnell S, Domico K, Zeitner B, Bjork A, Anderson D, Mason MJ, Whalen E, Vargas O, Popov D, Rinchai D, Jourde-Chiche N, Chiche L, Quinn C, Chaussabel D. An interactive web application for the dissemination of human systems immunology data. J Transl Med. 2015;13:196. PMID: 26088622, PMCID: PMC4474328.