Daniel J. Campbell, PhD
Dr. Campbell graduated with honors from the University of Michigan in 1993, and received his PhD in Molecular and Cell Biology from the University of California, Berkeley in 1998. Following a postdoctoral fellowship at Stanford University, Dr. Campbell joined the faculty of the Benaroya Research Institute as an Assistant Member in 2003. He is also an Affiliate Assistant Professor in the Department of Immunology at the University of Washington School of Medicine.
Area of Research
Research in Dr. Campbell’s laboratory is focused on understanding the regulatory mechanisms that modulate immune responses during autoimmunity and infection. In particular, we are studying how a population of leukocytes called regulatory T cells functions to restrain immune responses, and how these cells can have beneficial effects in preventing autoimmunity, but also can promote chronic infection with pathogens such as Mycobacterium tuberculosis.
Srivastava S, Koch LK, Campbell DJ. IFNαR Signaling in Effector but Not Regulatory T Cells Is Required for Immune Dysregulation during Type I IFN-Dependent Inflammatory Disease. J Immunol. 2014 Sep 15;193(6):2733-42.
Gratz IK, Campbell DJ. Organ-specific and memory Treg cells: specificity,development, function, and maintenance. Front Immunol. 2014 Jul 15;5:333.
Duhen T, Campbell DJ. IL-1β promotes the differentiation of polyfunctional human CR6+CXCR3+ Th1/17 cells that are specific for pathogenic and commensal microbes. J Immunol. 2014 Jul 1;193(1):120-9
Srivastava S, Koch MA, Pepper M, Campbell DJ. Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection. J Exp Med. 2014 May 5;211(5):961-74
Smigiel KS, Srivastava S, Stolley JM, Campbell DJ. Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation. Immunol Rev. 2014 May;259(1):40-59
Campbell DJ. MyD88 and IL-1: loosening T(reg) cells' firm grip. Trends Immunol. 2014 Mar;35(3):95-6
Smigiel KS, Richards E, Srivastava S, Thomas KR, Dudda JC, Klonowski KD, Campbell DJ. CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets. J Exp Med. 2014 Jan 13;211(1):121-36
Shafiani S, Dinh C, Ertelt JM, Moguche AO, Siddiqui I, Smigiel KS, Sharma P, Campbell DJ, Way SS, Urdahl KB. Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12. Immunity. 2013 Jun 27;38(6):1261-70
Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF. Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol. 2013 Apr;14(4):307-8
Koch MA, Thomas KR, Perdue NR, Smigiel KS, Srivastava S, Campbell DJ. T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2. Immunity. 2012 Sep 21;37(3):501-10
Suscovich TJ, Perdue NR, Campbell DJ. Type-1 immunity drives early lethality in scurfy mice. Eur J Immunol. 2012 Sep;42(9): 2305-10
Naik S, Bouladoux N, Wilhelm C, Molloy MJ, Salcedo R, Kastenmuller W, Deming C, Quinones M, Koo L, Conlan S, Spencer S, Hall JA, Dzutsev A, Kong H, Campbell DJ, Trinchieri G, Segre JA, Belkaid Y. Compartmentalized control of skin immunity by resident commensals. Science. 2012 Aug 31;337(6098):1115-9