2021 Publications
The following list highlights BRI's 2021 publications. More selective listings of publications are also included on scientist biography pages. BRI Principal Investigators are listed in bold.
Allenspach EJ, Soveg F, Finn LS, So L, Gorman JA, Rosen ABI, Skoda-Smith S, Wheeler MM, Barrow KA, Rich LM, Debley JS, Bamshad MJ, Nickerson DA, Savan R, Torgerson TR, Rawlings DJ. Germline SAMD9L truncation variants trigger global translational repression. J Exp Med. 2021 May 3;218(5):e20201195. doi: 10.1084/jem.20201195. PMID: 33724365 | PMC7970252
Altman MC, Calatroni A, Ramratnam S, Jackson DJ, Presnell S, Rosasco MG, Gergen PJ, Bacharier LB, O'Connor GT, Sandel MT, Kattan M, Wood RA, Visness CM, Gern JE; Inner City Asthma Consortium. Endotype of Allergic Asthma with Airway Obstruction in Urban Children. J Allergy Clin Immunol. 2021 Mar 10:S0091-6749(21)00373-0. doi: 10.1016/j.jaci.2021.02.040. PMID: 33713771 | PMC8429519
Altman MC, Flynn K, Rosasco MG, Dapas M, Kattan M, Lovinsky-Desir S, O'Connor GT, Gill MA, Gruchalla RS, Liu AH, Pongracic JA, Khurana Hershey GK, Zoratti EM, Teach SJ, Rastrogi D, Wood RA, Bacharier LB, LeBeau P, Gergen PJ, Togias A, Busse WW, Presnell S, Gern JE, Ober C, Jackson DJ; NIAID Inner City Asthma Consortium. Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children. J Allergy Clin Immunol. 2021 May 18:S0091-6749(21)00806-X. doi: 10.1016/j.jaci.2021.04.035. PMID: 34019912 | PMC8599524
Altman MC, Rinchai D, Baldwin N, Toufiq M, Whalen E, Garand M, Syed Ahamed Kabeer B, Alfaki M, Presnell SR, Khaenam P, Ayllón-Benítez A, Mougin F, Thébault P, Chiche L, Jourde- Brough HA, Lanser BJ, Sindher SB, Teng JMC, Leung DYM, Venter C, Chan SM, Santos AF, Bahnson HT, Guttman-Yassky E, Gupta RS, Lack G, Ciaccio CE, Sampath V, Nadeau KC, Nagler CR. Early intervention and prevention of allergic diseases. Allergy. 2021 Jul 13. doi: 10.1111/all.15006. PMID: 34255344
Arnett A, Moo KG, Flynn KJ, Sundberg TB, Johannessen L, Shamji AF, Gray NS, Decker T, Zheng Y, Gersuk VH, Rahman ZS, Levy DE, Marié IJ, Linsley PS, Xavier RJ, Khor B. The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4+ T Cells via a Novel CDK8-GATA3-FOXP3 Pathway. Mol Cell Biol. 2021 Aug 24;41(9):e0008521. doi: 10.1128/MCB.00085-21. PMID: 34124936 | PMC8384069
Asif M, Khor B. Two roads diverged: Emerging lessons from IVIG about hemolysis. Transfusion. 2021 Apr;61(4):993-995. doi: 10.1111/trf.16326. PMID: 33831225
Baharom F, Ramirez-Valdez RA, Tobin KKS, Yamane H, Dutertre CA, Khalilnezhad A, Reynoso GV, Coble VL, Lynn GM, Mulè MP, Martins AJ, Finnigan JP, Zhang XM, Hamerman JA, Bhardwaj N, Tsang JS, Hickman HD, Ginhoux F, Ishizuka AS, Seder RA. Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells. Nat Immunol. 2021 Jan;22(1):41-52. doi: 10.1038/s41590-020-00810-3. PMID: 33139915; PMCID: PMC7746638
Barone SM, Paul AG, Muehling LM, Lannigan JA, Kwok WW, Turner RB, Woodfolk JA, Irish JM. Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy. Elife. 2021 Aug 5;10:e64653. doi: 10.7554/eLife.64653. PMID: 34350827 | PMC8370768
Battaglia M, Buckner JH, Levings MK, Richardson SJ, Wong FS, Tree TI. Identifying the 'Achilles heel' of type 1 diabetes. Clin Exp Immunol. 2021 May;204(2):167-178. doi: 10.1111/cei.13570. PMID: 33368173 | PMC8062995
Becht E, Tolstrup D, Dutertre CA, Morawski PA, Campbell DJ, Ginhoux F, Newell EW, Gottardo R, Headley MB. High-throughput single-cell quantification of hundreds of proteins using conventional flow cytometry and machine learning. Sci Adv. 2021 Sep 24;7(39):eabg0505. doi: 10.1126/sciadv.abg0505. Epub 2021 Sep 22. PMID: 34550730 | PMC8457665
Bhatraju PK, Morrell ED, Zelnick L, Sathe NA, Chai XY, Sakr SS, Sahi SK, Sader A, Lum DM, Liu T, Koetje N, Garay A, Barnes E, Lawson J, Cromer G, Bray MK, Pipavath S, Kestenbaum BR, Liles WC, Fink SL, West TE, Evans L, Mikacenic C, Wurfel MM. Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study. Crit Care. 2021 Apr 19;25(1):148. doi: 10.1186/s13054-021-03547-z. PMID: 33874973 | PMC8054255
Bluestone JA, Buckner JH, Herold KC. Immunotherapy: Building a bridge to a cure for type 1 diabetes. Science. 2021 Jul 30;373(6554):510-516. doi: 10.1126/science.abh1654. PMID: 34326232
Boddul SV, Sharma RK, Dubnovitsky A, Raposo B, Gerstner C, Shen Y, Iyer VS, Kasza Z, Kwok WW, Winkler AR, Klareskog L, Malmström V, Bettini M, Wermeling F. In vitro and ex vitro functional characterization of human HLA-DRB1∗04 restricted T cell receptors. J Transl Autoimmun. 2021 Mar 3;4:100087. doi: 10.1016/j.jtauto.2021.100087. PMID: 33768201 | PMC7980064
Bogdani M, Faxius L, Fex M, Ramelius A, Wernersson A, Mordes JP, Blankenhorn EP, Lernmark Å. The Vbeta13 T Cell Receptor Monoclonal Antibody Reduces Hyaluronan and CD68+, CD3+, and CD8+ Cell Infiltrations to Delay Diabetes in Congenic BB DR Lyp/Lyp Rats. Front Endocrinol (Lausanne). 2021 Mar 16;12:629242. doi: 10.3389/fendo.2021.629242. PMID: 33815287 | PMC8010654
Bogdani M, Simeonovic C, Nagy N, Johnson PY, Chan CK, Wight TN. Detection of Glycosaminoglycans in Pancreatic Islets and Lymphoid Tissues. Methods Mol Biol. 2022;2303:695-717. Doi: 10.1007/978-1-0716-1398-6_53. PMID: 34626417
Bolouri H, Speake C, Skibinski D, Long SA, Hocking AM, Campbell DJ, Hamerman JA, Malhotra U, Buckner JH; Benaroya Research Institute COVID-19 Research Team. The COVID-19 immune landscape is dynamically and reversibly correlated with disease severity. J Clin Invest. 2021 Feb 1;131(3):e143648. doi: 10.1172/JCI143648. PMID: 33529167 | PMC7843226
Byrd AL, Liu M, Fujimura KE, Lyalina S, Nagarkar DR, Charbit B, Bergstedt J, Patin E, Harrison OJ, Quintana-Murci L, Mellman I, Duffy D, Albert ML; Milieu Intérieur Consortium. Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers. J Exp Med. 2021 Jan 4;218(1):e20200606. doi: 10.1084/jem.20200606. PMID: 33175106 | PMC7664509
Calise J, Garabatos N, Bajzik V, Farrington M, Robinson D, Jeong D, Londei M, Wambre E. Optimal human pathogenic TH2 cell effector function requires local epithelial cytokine signaling. J Allergy Clin Immunol. 2021 Mar 1:S0091-6749(21)00282-7. doi: 10.1016/j.jaci.2021.02.019. PMID: 33662368 | PMC8408285
Canny SP, Jackson SW. B Cells in Systemic Lupus Erythematosus: From Disease Mechanisms to Targeted Therapies. Rheum Dis Clin North Am. 2021 Aug;47(3):395-413. doi: 10.1016/j.rdc.2021.04.006. PMID: 34215370 | PMC8357318
Chow IT, Kwok WW. Identification of Human Antigen-Specific CD4+ Cells with Peptide-MHC Multimer Technologies. Methods Mol Biol. 2021;2285:153-163. 2021 Apr 30. doi: 10.1007/978-1-0716-1311-5_13. PMID: 33928551
Cook L, Reid KT, Häkkinen E, de Bie B, Tanaka S, Smyth DJ, White MP, Wong MQ, Huang Q, Gillies JK, Ziegler SF, Maizels RM, Levings MK. Induction of stable human FOXP3+ Tregs by a parasite-derived TGF-β mimic. Immunol Cell Biol. 2021 Sep;99(8):833-847. doi: 10.1111/imcb.12475. Epub 2021 Jun 3. PMID: 33929751 | PMC8453874
da Silva Antunes R, Sutherland A, Frazier A, Schulten V, Pomés A, Glesner J, Calatroni A, Altman MC, Wood RA, O'Connor GT, Pongracic JA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Gill M, Liu AH, Zoratti E, Kattan M, Busse PJ, Bacharier LB, Teach SJ, Wheatley LM, Togias A, Busse WW, Jackson DJ, Sette A. Heterogeneity of magnitude, allergen immunodominance, and cytokine polarization of cockroach allergen-specific T cell responses in allergic sensitized children. Clin Transl Allergy. 2021 Oct 13;11(8):e12073. doi: 10.1002/clt2.12073. PMID: 34691392 | PMC8514843
Diggins KE, Serti E, Muir V, Rosasco M, Lu T, Balmas E, Nepom G, Long SA, Linsley PS. Exhausted-like CD8+ T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects. JCI Insight. 2021 Feb 8;6(3):e142680. doi: 10.1172/jci.insight.142680. PMID: 33351781 | PMC7934874
Divine R, Dang HV, Ueda G, Fallas JA, Vulovic I, Sheffler W, Saini S, Zhao YT, Raj IX, Morawski PA, Jennewein MF, Homad LJ, Wan YH, Tooley MR, Seeger F, Etemadi A, Fahning ML, Lazarovits J, Roederer A, Walls AC, Stewart L, Mazloomi M, King NP, Campbell DJ, McGuire AT, Stamatatos L, Ruohola-Baker H, Mathieu J, Veesler D, Baker D. Designed proteins assemble antibodies into modular nanocages. Science. 2021 Apr 2;372(6537):eabd9994. doi: 10.1126/science.abd9994. PMID: 33795432 | PMC8592034
Farag AK, Roesner LM, Wieschowski S, Heratizadeh A, Eiz-Vesper B, Kwok WW, Valenta R, Werfel T. Specific T cells targeting Staphylococcus aureus fibronectin-binding protein 1 induce a type 2/type 1 inflammatory response in sensitized atopic dermatitis patients. Allergy. 2021 Oct 3. doi: 10.1111/all.15120. PMID: 34601735
Fisher HR, Lack G, Roberts G, Bahnson HT, Du Toit G. Medical algorithm: Early introduction of food allergens in high-risk populations. Allergy. 2021 May;76(5):1592-1594. doi: 10.1111/all.14717. PMID: 33346913
Flatt AJS, Greenbaum CJ, Shaw JAM, Rickels MR. Pancreatic islet reserve in type 1 diabetes. Ann N Y Acad Sci. 2021 Feb 6. doi: 10.1111/nyas.14572. PMID: 33550589
Frankel JK, Caumont F, DeBerg HA, Flores JP, Porter CR. Contemporary trends in management of stage 1 seminoma. Urol Oncol. 2021 Apr;39(4):240.e1-240.e8. doi: 10.1016/j.urolonc.2020.08.025. PMID: 33602622
Gitelman SE, Bundy BN, Ferrannini E, Lim N, Blanchfield JL, DiMeglio LA, Felner EI, Gaglia JL, Gottlieb PA, Long SA, Mari A, Mirmira RG, Raskin P, Sanda S, Tsalikian E, Wentworth JM, Willi SM, Krischer JP, Bluestone JA; Gleevec Trial Study Group. Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Diabetes Endocrinol. 2021 Aug;9(8):502-514. doi: 10.1016/S2213-8587(21)00139-X. PMID: 34214479 | PMC8494464
Greenbaum CJ, Serti E, Lambert K, Weiner LJ, Kanaparthi S, Lord S, Gitelman SE, Wilson DM, Gaglia JL, Griffin KJ, Russell WE, Raskin P, Moran A, Willi SM, Tsalikian E, DiMeglio LA, Herold KC, Moore WV, Goland R, Harris M, Craig ME, Schatz DA, Baidal DA, Rodriguez H, Utzschneider KM, Nel HJ, Soppe CL, Boyle KD, Cerosaletti K, Keyes-Elstein L, Long SA, Thomas R, McNamara JG, Buckner JH, Sanda S; ITN058AI EXTEND Study Team. IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes. JCI Insight. 2021 Nov 8;6(21):e150074. doi: 10.1172/jci.insight.150074. PMID: 34747368 | PMC8663550
Greenbaum CJ. A Key to T1D Prevention: Screening and Monitoring Relatives as Part of Clinical Care. Diabetes. 2021 May;70(5):1029-1037. doi: 10.2337/db20-1112. PMID: 33931405 | PMC8173797
Halken S, Muraro A, de Silva D, Khaleva E, Angier E, Arasi S, Arshad H, Bahnson HT, Beyer K, Boyle R, du Toit G, Ebisawa M, Eigenmann P, Grimshaw K, Hoest A, Jones C, Lack G, Nadeau K, O'Mahony L, Szajewska H, Venter C, Verhasselt V, Wong GWK, Roberts G; European Academy of Allergy and Clinical Immunology Food Allergy and Anaphylaxis Guidelines Group. EAACI guideline: Preventing the development of food allergy in infants and young children (2020 update). Pediatr Allergy Immunol. 2021 Mar 12. doi: 10.1111/pai.13496. PMID: 33710678
Harten IA, Evanko SP, Choe CH, Lee EW, Patel BN, Bogdani M, Wight TN, Lee UJ. The extracellular matrix molecules versican and hyaluronan in urethral and vaginal tissues in stress urinary incontinence. Neurourol Urodyn. 2021 Mar;40(3):771-782. doi: 10.1002/nau.24635. PMID: 33645869
Heide J, Schulte S, Kohsar M, Brehm TT, Herrmann M, Karsten H, Marget M, Peine S, Johansson AM, Sette A, Lütgehetmann M, Kwok WW, Sidney J, Schulze Zur Wiesch J. Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19. PLoS Pathog. 2021 Sep 16;17(9):e1009842. doi: 10.1371/journal.ppat.1009842. PMID: 34529740 | PMC8445433
Hill DL, Whyte CE, Innocentin S, Lee JL, Dooley J, Wang J, James EA, Lee JC, Kwok WW, Zand MS, Liston A, Carr EJ, Linterman MA. Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans. Elife. 2021 Nov 2;10:e70554. doi: 10.7554/eLife.70554. PMID: 34726156 | PMC8562996
Hirani P, Gauthier V, Allen CE, Wight TN, Pearce OMT. Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer. Front Oncol. 2021 Aug 30;11:712807. doi: 10.3389/fonc.2021.712807. PMID: 34527586 | PMC8435723
Hirpara DH, O'Rourke C, Azin A, Quereshy FA, Wexner SD, Chadi SA. Impact of BMI on Adverse Events After Laparoscopic and Open Surgery for Rectal Cancer. J Gastrointest Cancer. 2021 Mar 3. doi: 10.1007/s12029-021-00612-2. PMID: 33660225
Hughes-Austin JM, Ix JH, Ward SR, Weisman MH, ODell JR, Mikuls TR, Buckner JH, Gregersen PK, Keating RM, Demoruelle MK, Deane KD, Holers VM, Norris JM. Evaluating associations of joint swelling, joint stiffness and joint pain with physical activity in first-degree relatives of patients with rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA), a prospective cohort study. BMJ Open. 2021 Sep 14;11(9):e050883. doi: 10.1136/bmjopen-2021-050883. PMID: 34521672 | PMC8442039
Korpos É, Kadri N, Loismann S, Findeisen CR, Arfuso F, Burke GW 3rd, Richardson SJ, Morgan NG, Bogdani M, Pugliese A, Sorokin L. Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes. Diabetologia. 2021 Jul;64(7):1626-1641. doi: 10.1007/s00125-021-05453-z. PMID: 33912981 | PMC8187221
Krawiec M, Fisher HR, Du Toit G, Bahnson HT, Lack G. Overview of oral tolerance induction for prevention of food allergy-Where are we now? Allergy. 2021 Feb 4. doi: 10.1111/all.14758. PMID: 33539570
Lee HS, Chiorean MV, Boden E, Lord J, Irani S, Kozarek R, Larsen M, Ross A. Usefulness of Fluoroscopy for Endoscopic Balloon Dilation of Crohn's Disease-Related Strictures. Dig Dis Sci. 2021 Mar 19. doi: 10.1007/s10620-021-06935-1. PMID: 33740171
Leonard MM, Silvester JA, Leffler D, Fasano A, Kelly CP, Lewis SK, Goldsmith JD, Greenblatt E, Kwok WW, McAuliffe WJ, Galinsky K, Siegelman J, Chow IT, Wagner JA, Sapone A, Smithson G. Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial. Gastroenterology. 2021 Feb;160(3):720-733.e8. doi: 10.1053/j.gastro.2020.10.040. PMID: 33130104 | PMC7878429
Linsley PS, Greenbaum CJ, Nepom GT. Uncovering Pathways to Personalized Therapies in Type 1 Diabetes. Diabetes. 2021 Apr;70(4):831-841. doi: 10.2337/db20-1185. PMID: 33741606 | PMC7980192
Long SA, Speake C. Combination therapy in recent-onset type 1 diabetes. Lancet Diabetes Endocrinol. 2021 Apr;9(4):191-193. doi: 10.1016/S2213-8587(21)00044-9. PMID: 33662335
Lu X, Chen X, Forney C, Donmez O, Miller D, Parameswaran S, Hong T, Huang Y, Pujato M, Cazares T, Miraldi ER, Ray JP, de Boer CG, Harley JB, Weirauch MT, Kottyan LC. Global discovery of lupus genetic risk variant allelic enhancer activity. Nat Commun. 2021 Mar 12;12(1):1611. doi: 10.1038/s41467-021-21854-5. PMID: 33712590 | PMC7955039
Malinczak CA, Parolia A, Fonseca W, Morris S, Rasky AJ, Bawa P, Zhang Y, Mire MM, Ziegler SF, Ptaschinski C, Chinnaiyan AM, Lukacs NW. TSLP-Driven Chromatin Remodeling and Trained Systemic Immunity after Neonatal Respiratory Viral Infection. J Immunol. 2021 Mar 15;206(6):1315-1328. doi: 10.4049/jimmunol.2001205. PMID: 33514510
Marié IJ, Brambilla L, Azzouz D, Chen Z, Baracho GV, Arnett A, Li HS, Liu W, Cimmino L, Chattopadhyay P, Silverman G, Watowich SS, Khor B, Levy DE. Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome. Elife. 2021 Aug 11;10:e68371. doi: 10.7554/eLife.68371. PMID: 34378531 | PMC8376249
Matthew C Altman, Darawan Rinchai, Nicole Baldwin, Mohammed Toufiq, Elizabeth Whalen, Mathieu Garand, Basirudeen Syed Ahamed Kabeer, Mohamed Alfaki, Scott R Presnell, Prasong Khaenam, Aaron Ayllón-Benítez, Fleur Mougin, Patricia Thébault, Laurent Chiche, Noemie Jourde-Chiche, J Theodore Phillips, Goran Klintmalm, Anne O'Garra, Matthew Berry, Chloe Bloom, Robert J Wilkinson, Christine M Graham, Marc Lipman, Ganjana Lertmemongkolchai, Davide Bedognetti, Rodolphe Thiebaut, Farrah Kheradmand, Asuncion Mejias, Octavio Ramilo , Karolina Palucka, Virginia Pascual, Jacques Banchereau, Damien Chaussabel. Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data. Nat Commun. 2021 Jul 19;12(1):4385. doi: 10.1038/s41467-021-24584-w. PMID: 34282143 | PMC8289976
Mikacenic C, Bhatraju P, Robinson-Cohen C, Kosamo S, Fohner AE, Dmyterko V, Long SA, Cerosaletti K, Calfee CS, Matthay MA, Walley KR, Russell JA, Christie JD, Meyer NJ, Christiani DC, Wurfel MM. Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness. Crit Care Med. 2021 Sep 29. doi: 10.1097/CCM.0000000000005333. PMID: 34593707
Mittelsteadt KL, Hayes ET, Campbell DJ. ICOS signaling limits regulatory T cell accumulation and function in visceral adipose tissue. J Exp Med. 2021 Jun 7;218(6):e20201142. doi: 10.1084/jem.20201142. PMID: 33881452 | PMC8065270
Murphy RC, Altman MC. Ignition sequence start: epithelial allergen sensing and regulation of the allergic inflammatory response. Nat Immunol. 2021 Oct;22(10):1207-1209. doi: 10.1038/s41590-021-01005-0. PMID: 34531561
Nasser J, Bergman DT, Fulco CP, Guckelberger P, Doughty BR, Patwardhan TA, Jones TR, Nguyen TH, Ulirsch JC, Lekschas F, Mualim K, Natri HM, Weeks EM, Munson G, Kane M, Kang HY, Cui A, Ray JP, Eisenhaure TM, Collins RL, Dey K, Pfister H, Price AL, Epstein CB, Kundaje A, Xavier RJ, Daly MJ, Huang H, Finucane HK, Hacohen N, Lander ES, Engreitz JM. Genome-wide enhancer maps link risk variants to disease genes. Nature. 2021 May;593(7858):238-243. doi: 10.1038/s41586-021-03446-x. PMID: 33828297
Nguyen H, Guyer P, Ettinger RA, James EA. Non-Genetically Encoded Epitopes Are Relevant Targets in Autoimmune Diabetes. Biomedicines. 2021 Feb 17;9(2):202. doi: 10.3390/biomedicines9020202. PMID: 33671312 | PMC7922826
Orlov M, Morrell ED, Dmyterko V, Hamerman JA, Wurfel MM, Mikacenic C. Endotracheal aspirates contain a limited number of lower respiratory tract immune cells. Crit Care. 2021 Jan 6;25(1):14. doi: 10.1186/s13054-020-03432-1. PMID: 33407749 | PMC7787413
Orozco SL, Canny SP, Hamerman JA. Signals governing monocyte differentiation during inflammation. Curr Opin Immunol. 2021 Aug 16;73:16-24. doi: 10.1016/j.coi.2021.07.007. PMID: 34411882 | PMC8648978
Oyesola OO, Shanahan MT, Kanke M, Mooney BM, Webb LM, Smita S, Matheson MK, Campioli P, Pham D, Früh SP, McGinty JW, Churchill MJ, Cahoon JL, Sundaravaradan P, Flitter BA, Mouli K, Nadjsombati MS, Kamynina E, Peng SA, Cubitt RL, Gronert K, Lord JD, Rauch I, von Moltke J, Sethupathy P, Tait Wojno ED. PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection. J Exp Med. 2021 Sep 6;218(9):e20202178. doi: 10.1084/jem.20202178. PMID: 34283207 | PMC8294949
Pham MN, Khoryati L, Jamison BL, Hayes E, Sullivan JM, Campbell DJ, Gavin MA. In Vivo Expansion of Antigen-Specific Regulatory T Cells through Staggered Fc.IL-2 Mutein Dosing and Antigen-Specific Immunotherapy. Immunohorizons. 2021 Sep 28;5(9):782-791. doi: 10.4049/immunohorizons.2100051. PMID: 34583939
Piganelli JD, Mamula MJ, James EA. The Role of β Cell Stress and Neo-Epitopes in the Immunopathology of Type 1 Diabetes. Front Endocrinol (Lausanne). 2021 Feb 18;11:624590. doi: 10.3389/fendo.2020.624590. PMID: 33679609 | PMC7930070
Pj White M, Smyth DJ, Cook L, Ziegler SF, Levings MK, Maizels RM. The parasite cytokine mimic Hp-TGM potently replicates the regulatory effects of TGF-β on murine CD4+ T cells. Immunol Cell Biol. 2021 May 14. doi: 10.1111/imcb.12479. PMID: 33988885
Pyfrom S, Paneru B, Knox JJ, Cancro MP, Posso S, Buckner JH, Anguera MC. The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2024624118. doi: 10.1073/pnas.2024624118. PMID: 34103397 | PMC8214693
Rigby W, Buckner JH, Louis Bridges S Jr, Nys M, Gao S, Polinsky M, Ray N, Bykerk V. HLA-DRB1 risk alleles for RA are associated with differential clinical responsiveness to abatacept and adalimumab: data from a head-to-head, randomized, single-blind study in autoantibody-positive early RA. Arthritis Res Ther. 2021 Sep 18;23(1):245. doi: 10.1186/s13075-021-02607-7. PMID: 34537057 | PMC8449494
Rinchai D, Roelands J, Toufiq M, Hendrickx W, Altman MC, Bedognetti D, Chaussabel D. BloodGen3Module: Blood transcriptional module repertoire analysis and visualization using R. Bioinformatics. 2021 Feb 24:btab121. doi: 10.1093/bioinformatics/btab121. PMID: 33624743 | PMC8388021
Robertson CC, Inshaw JRJ, Onengut-Gumuscu S, Chen WM, Santa Cruz DF, Yang H, Cutler AJ, Crouch DJM, Farber E, Bridges SL Jr, Edberg JC, Kimberly RP, Buckner JH, Deloukas P, Divers J, Dabelea D, Lawrence JM, Marcovina S, Shah AS, Greenbaum CJ, Atkinson MA, Gregersen PK, Oksenberg JR, Pociot F, Rewers MJ, Steck AK, Dunger DB; Type 1 Diabetes Genetics Consortium, Wicker LS, Concannon P, Todd JA, Rich SS. Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. Nat Genet. 2021 Jun 14. doi: 10.1038/s41588-021-00880-5. PMID: 34127860 | PMC8273124
Rodda LB, Netland J, Shehata L, Pruner KB, Morawski PA, Thouvenel CD, Takehara KK, Eggenberger J, Hemann EA, Waterman HR, Fahning ML, Chen Y, Hale M, Rathe J, Stokes C, Wrenn S, Fiala B, Carter L, Hamerman JA, King NP, Gale M Jr, Campbell DJ, Rawlings DJ, Pepper M. Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19. Cell. 2021 Jan 7;184(1):169-183.e17. doi: 10.1016/j.cell.2020.11.029. PMID: 33296701 | PMC7682481
Rodriguez-Calvo T, Christoffersson G, Bender C, von Herrath MG, Mallone R, Kent SC, James EA. Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes? Front Immunol. 2021 Jun 16;12:683091. doi: 10.3389/fimmu.2021.683091. PMID: 34220832 | PMC8242234
Rose LM, DeBerg HA, Vishnu P, Frankel JK, Manjunath AB, Flores JPE, Aboulafia DM. Incidence of Skin and Respiratory Immune-Related Adverse Events Correlates With Specific Tumor Types in Patients Treated With Checkpoint Inhibitors. Front Oncol. 2021 Jan 15;10:570752. doi: 10.3389/fonc.2020.570752. PMID: 33520695 | PMC7844139
Ruffner MA, Hu A, Dilollo J, Benocek K, Shows D, Gluck M, Spergel JM, Ziegler SF, Hill DA, Cerosaletti K. Conserved IFN Signature between Adult and Pediatric Eosinophilic Esophagitis. J Immunol. 2021 Mar 15;206(6):1361-1371. doi: 10.4049/jimmunol.2000973. PMID: 33558373 | PMC7946729
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